Protein Information

Name interleukin (protein family or complex)
Synonyms Interleukin; Interleukins; interleukin receptor; interleukin receptors

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19210338 Hu KF, Huang KC, Ho YP, Lin YC, Ho KY, Wu YM, Yang YH, Tsai CC: Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. J Periodontal Res. 2009 Jun;44(3):378-85. Epub 2009 Feb 6.

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18397303 Rosado S, Rua-Figueroa I, Vargas JA, Garcia-Laorden MI, Losada-Fernandez I, Martin-Donaire T, Perez-Chacon G, Rodriguez-Gallego C, Naranjo-Hernandez A, Ojeda-Bruno S, Citores MJ, Perez-Aciego P: Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands. Int J Immunogenet. 2008 Jun;35(3):235-42. Epub 2008 Apr 7.


The purpose of this study was to examine whether several allelic variants in the polymorphic interleukin (IL)-10 promoter region were related with an increased risk of developing systemic lupus erythematosus (SLE) in Spanish patients from Canary Islands.
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20339193 Weng KP, Hsieh KS, Hwang YT, Huang SH, Lai TJ, Yuh YS, Hou YY, Lin CC, Huang SC, Chang CK, Lin MW, Ger LP: IL-10 Polymorphisms Are Associated With Coronary Artery Lesions in Acute Stage of Kawasaki Disease. Circ J. 2010 Mar 26.


Background: The literature regarding interleukin (IL)-10 polymorphisms and coronary artery lesions (CALs) in Kawasaki disease (KD) is limited.
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19673019 Sanchez R, Levy E, Costea F, Sinnett D: IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. World J Gastroenterol. 2009 Aug 14;15(30):3776-82.


AIM: To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-alpha and the interleukin (IL)-10 in childhood Crohn's disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes.
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19249119 Rezaei N, Aghamohammadi A, Mahmoudi M, Shakiba Y, Kardar GA, Mahmoudi M, Moradi B, Amirzargar AA: Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency. Immunobiology. 2010;215(1):81-7. Epub 2009 Feb 26.


Interleukin (IL)-4 and IL-10 levels could be altered in CVID patients, while cytokine production could be affected with polymorphisms of gene promoter regions.
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20305143 Dickinson AM, Pearce KF, Norden J, O'Brien SG, Holler E, Bickeboller H, Balavarca Y, Rocha V, Kolb HJ, Hromadnikova I, Sedlacek P, Niederwieser D, Brand R, Ruutu T, Apperley J, Szydlo R, Goulmy E, Siegert W, de Witte T, Gratwohl A: Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. Haematologica. 2010 Mar 19.


DESIGN AND METHODS: In this study, we assessed the effect of single nucleotide polymorphisms in genes for interleukin 1 receptor antagonist (IL1RN), interleukin (IL) 4 (IL4), IL6, IL10, interferon (IFN) IFNG, tumor necrosis factor (TNF) and cell surface receptors TNF receptor II (TNFRSFIB), vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) in a homogeneous cohort of 228 HLA identical sibling transplantations for chronic myeloid leukemia.
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17965799 Gonullu G, Basturk B, Evrensel T, Oral B, Gozkaman A, Manavoglu O: Association of breast cancer and cytokine gene polymorphism in Turkish women. Saudi Med J. 2007 Nov;28(11):1728-33.


All genotyping of tumor necrosis factor-alpha (TNF-alpha), tumor growth factor-beta1 (TGF-beta1), interleukin (IL)-10, IL-6, and interferon-gamma (IFN-gamma) experiments were performed using polymerase chain reaction sequence-specific primers.
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18596559 Hauber HP, Steffen A, Goldmann T, Vollmer E, Hung HL, Wollenberg B, Zabel P: Effect of steroids, acetyl-cysteine and calcium-activated chloride channel inhibitors on allergic mucin expression in sinus mucosa. Laryngoscope. 2008 Sep;118(9):1528-33.


METHODS: Explanted tissue from human sinus mucosa was stimulated with interleukin (IL)-4, IL-9, or IL-13.
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