| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18719599 | Lane MD, Wolfgang M, Cha SH, Dai Y: Regulation of food intake and energy expenditure by hypothalamic Int J Obes. 2008 Sep;32 Suppl 4:S49-54. is an inhibitor of transferase-1 (CPT1), an outer mitochondrial membrane enzyme that regulates entry into, and oxidation of fatty acids, by mitochondria. |
1(0,0,0,1) | Details |
| 19263251 | Ruenwai R, Cheevadhanarak S, Laoteng K: Overexpression of carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha. Mol Biotechnol. 2009 Jul;42(3):327-32. Epub 2009 Mar 5. According to the amino acid sequence homology and the conserved structural organization of the biotin carboxylase, carboxyl carrier protein, and carboxyl transferase domains, the cloned gene was characterized as a multi-domain ACC1 protein. |
1(0,0,0,1) | Details |
| 18761357 | Rodriguez A, Catalan V, Becerril S, Gil MJ, Mugueta C, Gomez-Ambrosi J, Fruhbeck G: Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats. Life Sci. 2008 Oct 10;83(15-16):540-9. Epub 2008 Aug 14. The expression of AdipoR1 and AdipoR2, carboxylase (ACC), as well as palmitoyl transferase 1 (CPT1), were increased in skeletal muscle of SHR. |
1(0,0,0,1) | Details |
| 18071271 | Yun JW, Kim YK, Lee BS, Kim CW, Hyun JS, Baik JH, Kim JJ, Kim BH: Effect of dietary on cytochrome P450 2E1-dependent alcoholic liver damage: enhancement of fatty acid oxidation. Biosci Biotechnol Biochem. 2007 Dec;71(12):2999-3006. Epub 2007 Dec 7. treatment significantly elevated hepatic CYP2E1 expression while simultaneously reducing hepatic phospho- carboxylase (p-ACC) and palmitoyl-transferase 1 (CPT-1) levels. |
1(0,0,0,1) | Details |
| 20060923 | Chen J, Tang X, Zhang Y, Ma H, Zou S: Effects of maternal treatment of on serum lipid profile and hepatic lipid metabolism-related gene expression in embryonic chickens. Comp Biochem Physiol B Biochem Mol Biol. 2010 Apr;155(4):380-6. Epub 2010 Jan 10. The expression of carboxylase (ACC) and palmitoyl transferase I (CPTI) gene was also reduced following treatment with 20mg /kg at hatching. |
1(0,0,0,1) | Details |
| 17855643 | Kume S, Uzu T, Araki S, Sugimoto T, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Kubota N, Terauchi Y, Kadowaki T, Haneda M, Kashiwagi A, Koya D: Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. J Am Soc Nephrol. 2007 Oct;18(10):2715-23. Epub 2007 Sep 12. In addition, renal lipolysis was suppressed, determined by reduced mRNA expression of the lipolytic enzyme palmitoyl acyl- transferase 1 and by reduced activity of AMP-activated protein kinase. |
1(0,0,0,1) | Details |
| 19390150 | Madauss KP, Burkhart WA, Consler TG, Cowan DJ, Gottschalk WK, Miller AB, Short SA, Tran TB, Williams SP: The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):449-61. Epub 2009 Apr 18. The use of biophysical assays has permitted the identification of a specific C-terminal truncation of the 826-residue human ACC2 carboxyl transferase (CT) domain that is both functionally competent to bind inhibitors and crystallizes in their presence. |
1(0,0,0,1) | Details |
| 17522981 | Patil PB, Minteer SD, Mielke AA, Lewis LR, Casmaer CA, Barrientos EJ, Ju JS, Smith JL, Fisher JS: affects insulin-stimulated transport in myotubes. Arch Physiol Biochem. 2007 Feb;113(1):13-24. We assessed transport after polyamine-mediated delivery of to myotubes, after incubation with dichloroacetate (which reportedly increases levels), or after exposure of myotubes to 2-bromopalmitate, a palmitoyl transferase I inhibitor. |
1(0,0,0,1) | Details |
| 19288015 | Celik A, Kano Y, Tsujinaka S, Okada S, Takao K, Takagi M, Chohnan S, Soda K, Kawakami M, Konishi F: Decrease in and its background metabolic alterations in murine model of cancer cachexia. Oncol Rep. 2009 Apr;21(4):1105-11. Expression of / N-1 acetyl transferase (SSAT) assessed by real-time PCR was significantly increased in cachectic mice. |
1(0,0,0,1) | Details |
| 17960559 | Fediuc S, Pimenta AS, Gaidhu MP, Ceddia RB: Activation of AMP-activated protein kinase, inhibition of pyruvate dehydrogenase activity, and redistribution of substrate partitioning mediate the acute insulin-sensitizing effects of troglitazone in skeletal muscle cells. J Cell Physiol. 2008 May;215(2):392-400. Exposure of L6 myotubes to troglitazone for 1 h significantly increased phosphorylation of AMPK and ACC, which was followed by approximately 30% and approximately 60% increases in oxidation and palmitoyl transferase-1 (CPT-1) activity, respectively. |
1(0,0,0,1) | Details |
| 18247344 | Lee CK, Cheong HK, Ryu KS, Lee JI, Lee W, Jeon YH, Cheong C: Biotinoyl domain of human carboxylase: Structural insights into the carboxyl transfer mechanism. Proteins. 2008 Aug;72(2):613-24. In ACC, the biotinoyl domain performs a critical function by transferring an activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, followed by carboxyl transfer to |
1(0,0,0,1) | Details |
| 18946183 | Yun JW, Shin ES, Cho SY, Kim SH, Kim CW, Lee TR, Kim BH: The effects of BADGE and on the time-course response of adiponectin and lipid oxidative enzymes in high fat diet-fed C57BL/6J mice: correlation with reduced adiposity and steatosis. Exp Anim. 2008 Oct;57(5):461-9. ACC phosphorylation and palmitoyl-transferase-1 (CPT1) activity have been shown to be rate controlling factors in fatty acid oxidation. |
1(0,0,0,1) | Details |
| 17704960 | Tang X, Ma H, Zou S, Chen W: Effects of on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. Lipids. 2007 Nov;42(11):1025-33. Epub 2007 Aug 18. The expression of peroxisome proliferators-activated receptor alpha (PPARalpha) and palmitoyl transferase I (CPTI) mRNA was decidedly enhanced following treatment with and a similar tendency was also observed in the expression of acyl- oxidase 1 (ACOX1). |
1(0,0,0,1) | Details |
| 19457654 | Koopman M, Venderbosch S, van Tinteren H, Ligtenberg MJ, Nagtegaal I, Van Krieken JH, Punt CJ: Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study. Eur J Cancer. 2009 Jul;45(11):1999-2006. Epub 2009 May 18. We have tested several biomarkers [dihydropyrimidine dehydrogenase (DPD), phosphoribosyl transferase (OPRT), thymidine phosphorylase (TP), thymidylate synthase (TS) and excision cross-complementing gene (ERCC1)] for their prognostic and predictive value in relation to the outcome of chemotherapy in tumour tissues of 556 advanced colorectal cancer (ACC) patients who were randomised between sequential treatment and combination treatment in the CApecitabine, IRinotecan, Oxaliplatin (CAIRO) study. |
1(0,0,0,1) | Details |