| Name | LKB1 |
|---|---|
| Synonyms | LKB 1; LKB1; NY REN 19 antigen; PJS; STK11; Serine/Threonine protein kinase 11; Serine/threonine kinase 11; Serine/threonine protein kinase 11 variant… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18460326 | Sleeman MW, Latres E: The CAMplexities of central ghrelin. . Cell Metab. 2008 May;7(5):361-2. In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with carboxylase (ACC) in a pathway distinct from the more established /LKB1 pathway. |
31(0,1,1,1) | Details |
| 17521700 | Conde E, Suarez-Gauthier A, Garcia-Garcia E, Lopez-Rios F, Lopez-Encuentra A, Garcia-Lujan R, Morente M, Sanchez-Verde L, Sanchez-Cespedes M: Specific pattern of LKB1 and phospho- carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol. 2007 Sep;38(9):1351-60. Epub 2007 May 22. |
10(0,0,0,10) | Details |
| 18669938 | Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW: Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. J Appl Physiol. 2008 Oct;105(4):1218-27. Epub 2008 Jul 31. |
7(0,0,0,7) | Details |
| 17925454 | Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW: LKB1 and the regulation of and fatty acid oxidation in muscle. . Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1572-9. Epub 2007 Oct 9. |
5(0,0,0,5) | Details |
| 19447226 | Murase T, Misawa K, Haramizu S, Hase T: -induced activation of the LKB1/AMP-activated protein kinase pathway. Biochem Pharmacol. 2009 Jul 1;78(1):78-84. Epub 2009 Mar 31. |
4(0,0,0,4) | Details |
| 18474592 | Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH: Reactive species is required for the activation of the AMP-activated protein kinase by in vivo. J Biol Chem. 2008 Jul 18;283(29):20186-97. Epub 2008 May 12. Exposure of confluent bovine aortic endothelial cells to dose-dependently increased phosphorylation of AMPK at (172) and activities of AMPK, which was in parallel with increased detection of both LKB1 phosphorylation at Ser (428) and LKB1 nuclear export. |
3(0,0,0,3) | Details |
| 18482975 | Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008 Jul 18;283(29):20015-26. Epub 2008 May 14. Here we show that polyphenols, including and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser (428), and AMPK activity. |
3(0,0,0,3) | Details |
| 18992226 | Hwang SL, Kim HN, Jung HH, Kim JE, Choi DK, Hur JM, Lee JY, Song H, Song KS, Huh TL: Beneficial effects of on and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1253-8. Epub 2008 Nov 4. These effects were all reversed by pretreatment with AMPK inhibitor Compound C or LKB1 destabilizer radicicol. |
2(0,0,0,2) | Details |
| 17855357 | Goransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K: Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12. Phosphorylation of AMPK and ACC in response to A-769662 is also abolished in isolated mouse skeletal muscle lacking LKB1, a major upstream kinase for AMPK in this tissue. |
2(0,0,0,2) | Details |
| 18435912 | Hwang SL, Yang BK, Lee JY, Kim JH, Kim BD, Suh KH, Kim DY, Kim MS, Song H, Park BS, Huh TL: Isodihydrocapsiate stimulates plasma uptake by activation of AMP-activated protein kinase. Biochem Biophys Res Commun. 2008 Jun 27;371(2):289-93. Epub 2008 Apr 22. We report that a synthetic structural isomer of dihydrocapsiate, isodihydrocapsiate (8-methylnonanoic acid 3--4-methoxy benzyl ester) improves type 2 diabetes by activating AMPK through the LKB1 pathway. |
2(0,0,0,2) | Details |
| 20110356 | Hao W, Chang CP, Tsao CC, Xu J: Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization. J Biol Chem. 2010 Jan 28. In OXPHOS-dependent LKB1-wild type cells, oligomycin induces 5-8% ATP drops and transient AMPK activation during the initial 1-2 h. |
1(0,0,0,1) | Details |
| 19874425 | Rattan R, Giri S, Hartmann L, Shridhar V: attenuates ovarian cancer cell growth in an AMP- kinase dispensable manner. J Cell Mol Med. 2009 Oct 29. This observation was further supported by using siRNA approach to downregulate LKB1 in ovarian cancer cells. |
1(0,0,0,1) | Details |
| 19756961 | Ramnanan CJ, McMullen DC, Groom AG, Storey KB: The regulation of AMPK signaling in a natural state of profound metabolic rate depression. Mol Cell Biochem. 2010 Feb;335(1-2):91-105. Epub 2009 Sep 15. Accordingly, approximately 2-fold increases in AMPKalpha1 protein and activity were observed with LKB1 immunoprecipitates from estivating snails. |
1(0,0,0,1) | Details |
| 18687367 | Thors B, Halldorsson H, Jonsdottir G, Thorgeirsson G: Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulation. Biochim Biophys Acta. 2008 Oct;1783(10):1893-902. Epub 2008 Jul 18. We examined the involvement of two upstream kinases in AMPK activation in cultured human umbilical endothelial cells, LKB1 stimulated by a rise in intracellular AMP/ATP ratio, and Ca (+2)/CaM kinase kinase (CaMKK) responding to elevation of intracellular Ca (+2). |
1(0,0,0,1) | Details |
| 18715874 | Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y: AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J Biol Chem. 2008 Oct 24;283(43):28897-908. Epub 2008 Aug 20. UV and H (2) O (2) also phosphorylate LKB1, an upstream signal of AMPK, in an epidermal growth factor receptor-dependent manner. |
1(0,0,0,1) | Details |
| 19459711 | Way TD, Lin HY, Kuo DH, Tsai SJ, Shieh JC, Wu JC, Lee MR, Lin JK: Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells. J Agric Food Chem. 2009 Jun 24;57(12):5257-64. PR-3-5s decreased the expression of fatty acid synthase (FASN) and inhibited the activity of carboxylase (ACC) by stimulating AMP-activated protein kinase (AMPK) through the LKB1 pathway. |
1(0,0,0,1) | Details |