| Name | stearoyl coenzyme A desaturase |
|---|---|
| Synonyms | Acyl CoA desaturase; Acyl Coenzyme A desaturase; Delta(9) desaturase; Delta 9 desaturase; FADS 5; FADS5; Fatty acid desaturase; PRO0998… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19182950 | Kim do Y, Yuan HD, Chung IK, Chung SH: Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells. J Agric Food Chem. 2009 Feb 25;57(4):1532-7. Genes for fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1), well-known target molecules of SREBP1c, were also suppressed. |
1(0,0,0,1) | Details |
| 20019905 | Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Huppi PS: Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect. 2009 Oct;117(10):1549-55. Epub 2009 Jun 29. This excess of pWAT was associated with adipocyte hypertrophy and overexpression of lipogenic genes such as C/EBP-alpha (CAAT enhancer binding protein alpha), PPAR-gamma (peroxisome proliferator-activated receptor gamma), SREBP-1C (sterol regulatory element binding protein-1C), LPL (lipoprotein lipase), FAS (fatty acid synthase), and SCD-1 (stearoyl-CoA desaturase 1). |
1(0,0,0,1) | Details |
| 20154153 | Lengi AJ, Corl BA: Factors influencing the differentiation of bovine preadipocytes in vitro. J Anim Sci. 2010 Feb 12. Differentiating stromal-vascular cells in the presence of trans-10, cis-12 CLA inhibited differentiation of stromal-vascular cells into mature adipocytes, reducing radiolabeled incorporation into lipids (P < 0.001), stearoyl-CoA desaturase-1 mRNA (P <0.05) and protein abundance (P < 0.05) and ACCalpha protein abundance (P < 0.05). |
1(0,0,0,1) | Details |
| 17391151 | Clapham JC, Arch JR: Thermogenic and metabolic antiobesity drugs: rationale and opportunities. Diabetes Obes Metab. 2007 May;9(3):259-75. ATP citrate lyase, fatty acid synthase, carboxylase (ACC)], fatty acid interconversion [stearoyl-CoA desaturase (SCD)] and triglyceride synthesis (e.g. acyl-CoA : diacylglycerol acyltransferase) may all be thermogenic. |
1(0,0,0,1) | Details |
| 19638267 | Tsiplakou E, Flemetakis E, Kalloniati C, Papadomichelakis G, Katinakis P, Zervas G: Sheep and goats differences in CLA and fatty acids milk fat content in relation with mRNA stearoyl-CoA desaturase and lipogenic genes expression in their mammary gland. J Dairy Res. 2009 Nov;76(4):392-401. Epub 2009 Jul 29. |
2(0,0,0,2) | Details |
| 17449569 | Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR: downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J Nutr. 2007 May;137(5):1127-31. SREBP-1 is also a transcription factor for lipogenic genes, such as desaturase1 (SCD1), acyltransferase (GPAT), and acetyl-CoA carboxylase (ACC) 1, and ACC2. |
2(0,0,0,2) | Details |
| 19684259 | Canovas A, Estany J, Tor M, Pena RN, Doran O: carboxylase and stearoyl-CoA desaturase protein expression in subcutaneous adipose tissue is reduced in pigs selected for decreased backfat thickness at constant intramuscular fat content. J Anim Sci. 2009 Dec;87(12):3905-14. Epub 2009 Aug 14. |
2(0,0,0,2) | Details |
| 19427916 | Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8. The mRNA levels of malic enzyme (ME), ATP-citrate lyase (ACL), acetyl-CoA carboxylase alpha (ACCalpha), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1) and thyroid hormone responsive Spot 14 (Spot 14) declined in response to fasting. |
1(0,0,0,1) | Details |
| 19383549 | Wang PH, Ko YH, Chin HJ, Hsu C, Ding ST, Chen CY: The effect of feed restriction on expression of hepatic lipogenic genes in broiler chickens and the function of SREBP1. Comp Biochem Physiol B Biochem Mol Biol. 2009 Aug;153(4):327-31. Epub 2009 Apr 19. Indeed, the mRNA concentrations for fatty acid synthase (FAS), malic enzyme, and stearoyl coenzyme A desaturase were almost undetectable after the 24 h fasting. |
1(0,0,0,1) | Details |
| 20041784 | Cho K, Kim SJ, Park SH, Kim S, Park T: Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food. 2009 Dec;12(6):1293-301. Chronic alcohol consumption up-regulated the hepatic expression of genes involved in inflammation, fatty acid synthesis, and metabolism, including tumor necrosis factor alpha (TNFalpha), liver X receptor alpha (LXRalpha), sterol regulatory element-binding protein (SREBP)-1c, fatty acid synthase, acetyl-coenzyme A carboxylase alpha (ACC), stearoyl-coenzyme A desaturase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), and low-density lipoprotein receptor (LDLR). |
1(0,0,0,1) | Details |
| 20139613 | Yuan HD, Yuan HY, Chung SH, Jin GZ, Piao GC: An active part of Artemisia sacrorum Ledeb. attenuates hepatic lipid accumulation through activating AMP-activated protein kinase in human HepG2 cells. Biosci Biotechnol Biochem. 2010 Feb 23;74(2):322-8. Epub 2010 Feb 7. EE down-regulated the lipogenesis gene expression of sterol regulatory element-binding protein 1c (SREBP1c) and its target genes, such as fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1), in a time- and dose-dependent manner. |
1(0,0,0,1) | Details |
| 19932008 | Kim EJ, Jin XJ, Kim YK, Oh IK, Kim JE, Park CH, Chung JH: UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging. J Dermatol Sci. 2010 Jan;57(1):19-26. Epub 2009 Nov 20. The expressions of genes related to lipid synthesis, including carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), sterol regulatory element binding proteins (SREBPs), and peroxisome proliferator-activated receptors (PPARgamma) were also markedly decreased. |
1(0,0,0,1) | Details |