Protein Information

Name statins
Synonyms STN; statin; statins

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18439049 Lee HY, Cooke CE, Robertson TA: Use of secondary prevention drug therapy in patients with acute coronary syndrome after hospital discharge. J Manag Care Pharm. 2008 Apr;14(3):271-80.


The American College of Cardiology/American Heart Association (ACC/AHA) guidelines on the management of patients with unstable angina and non-ST-segment elevation myocardial infarction (2002-2004) recommend (1) angiotensinconverting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) for ACE inhibitor intolerance, (2) beta-blockers, and (3) statins for long-term treatment of patients after an acute coronary event.
5(0,0,0,5) Details
18345999 Cho L, Hoogwerf B, Huang J, Brennan DM, Hazen SL: Gender differences in utilization of effective cardiovascular secondary prevention: a Cleveland clinic prevention database study. J Womens Health. 2008 May;17(4):515-21.


The primary objective was to evaluate use of effective secondary preventive therapies, by gender, as outlined in the ACC/AHA guidelines, such as antiplatelet therapy, beta-blockers, statins, and angiotensin-converting enzyme (ACE) inhibitors.
2(0,0,0,2) Details
17654318 Gowdak LH, Arantes RL, de Paula FJ, Krieger EM, De Lima JJ: Underuse of American College of Cardiology/American Heart Association Guidelines in hemodialysis patients. Ren Fail. 2007;29(5):559-65.


The use of angiotensin-converting enzyme inhibitors (ACE-I), beta-blockers, aspirin, and statins was assessed in 271 (72% males, 66% Caucasians) high-risk ESRD patients on hemodialysis.
2(0,0,0,2) Details
19498441 Izumi Y, Shiota M, Kusakabe H, Hikita Y, Nakao T, Nakamura Y, Muro T, Miura K, Yoshiyama M, Iwao H: Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase. Hypertens Res. 2009 Aug;32(8):675-9. Epub 2009 Jun 5.


Statins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability.
2(0,0,0,2) Details
18751508 Timoteo AT, Fiarresga A, Feliciano J, Ferreira ML, Oliveira JA, Serra J, Ferreira R: Adherence to guidelines in the treatment of acute coronary syndromes: progress over time. Rev Port Cardiol. 2008 Jun;27(6):803-12.


Treatment with clopidogrel (6% vs. 87%), beta-blockers (54% vs. 79%), angiotensin-converting enzyme inhibitors (72% vs. 84%) and statins (78% vs. 91%) increased (all with p < 0.001).
2(0,0,0,2) Details
18599796 Li X, Han Y, Pang W, Li C, Xie X, Shyy JY, Zhu Y: AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1789-95. Epub 2008 Jul 3.


CONCLUSIONS: The activation of eNOS by AMPK during EPC differentiation provides a novel mechanism for the pleiotropic effects of statins in benefiting the cardiovascular system.
1(0,0,0,1) Details
19561793 David RB: American college of cardiology 57th scientific sessions, 2008. P T. 2008 May;33(5):296-8.


The ENHANCE findings intensified interest in both non-lipid-lowering benefits of statins and non-statins for lipid lowering.
1(0,0,0,1) Details
19069375 Ortega-Gil J, Perez-Cardona JM: Unstable angina and non ST elevation acute coronary syndromes. P R Health Sci J. 2008 Dec;27(4):395-401.


Evidence base scientific data insists upon using aggressive medical therapy (statins, anti-platelets, beta blockers [BBs], angiotensin converting enzyme inhibitors [ACE-Is], and control of coronary risk factors) as well as mechanical reperfusion, whether by percutaneous coronary intervention (PCI) or by coronary artery bypass graft (CABG).
1(0,0,0,1) Details
18180524 Cohen M, Diez JE, Levine GN, Ferguson JJ 3rd, Morrow DA, Rao SV, Zidar JP: Pharmacoinvasive management of acute coronary syndrome: incorporating the 2007 ACC/AHA guidelines: the CATH (cardiac catheterization and antithrombotic therapy in the hospital) Clinical Consensus Panel Report--III. J Invasive Cardiol. 2007 Dec;19(12):525-38; quiz 539-40.


The addition of statins, angiotensin-converting enzyme (ACE) inhibitors and beta-blockers is also stressed as part of a comprehensive secondary cardioprotective strategy for patients with coronary heart disease.
1(0,0,0,1) Details