Protein Information

Name L FABP
Synonyms FABP 1; FABP1; FABPL; Fatty acid binding protein 1; Fatty acid binding protein liver; L FABP; Z protein; Fatty acid binding protein 1s…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19954950 Kim HJ, Yuan J, Norris K, Vaziri ND: High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney. J Nutr Biochem. 2009 Nov 30.


The CRF group consuming a regular diet exhibited growth retardation; azotemia; proteinuria; glomerulosclerosis; tubulointerstitial injury; heavy lipid accumulation in the remnant kidney; up-regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), ATP-binding cassette transporter-1 (ABCA1), liver X receptor (LXR) alpha/beta, carbohydrate-responsive element binding protein (ChREBP) and acyl-CoA carboxylase (ACC); and down-regulation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha), carnitine palmitoyltransferase-1 (CPT1) and liver-type fatty acid binding protein (L-FABP).
2(0,0,0,2) Details
19878707 Cho KH, Kim HJ, Kamanna VS, Vaziri ND: Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.


RESULTS: CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl-CoA carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG-CoA reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A.
2(0,0,0,2) Details