Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
20226125 Borrayo-Sanchez G, Pacheco-Bouthillier A, Mendoza-Valdez L, Isordia-Salas I, Arguero-Sanchez R, Careaga Reyna G: [Prognostic value of serum levels of interleukin-6 in patients with ST-segment elevation acute myocardial infarction.]. Cir Cir. 2010 Jan-Feb;78(1):25-30.

8(0,0,0,8) Details
19470040 Javor J, Chmurova N, Parnicka Z, Ferencik S, Grosse-Wilde H, Buc M, Svecova D: TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population. J Eur Acad Dermatol Venereol. 2010 Jan;24(1):65-8. Epub 2009 Apr 8.


OBJECTIVE: The aim of our case-control study was to investigate whether some of 22 single nucleotide polymorphisms (SNPs) in 13 cytokine genes (IL-1alpha, IL-1beta, IL-1RI, IL-1Ra, IL-4Ralpha, IL-12, IFN-gamma, TGF-beta1, TNF-alpha, IL-2, IL-4, IL-6 and IL-10) are associated with pemphigus vulgaris in the Slovak population.
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19052642 Ropelle ER, Fernandes MF, Flores MB, Ueno M, Rocco S, Marin R, Cintra DE, Velloso LA, Franchini KG, Saad MJ, Carvalheira JB: Central exercise action increases the AMPK and mTOR response to leptin. . PLoS One. 2008;3(12):e3856. Epub 2008 Dec 4.


Acute exercise is associated with increased sensitivity to the effects of leptin on food intake in an IL-6-dependent manner.
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17965799 Gonullu G, Basturk B, Evrensel T, Oral B, Gozkaman A, Manavoglu O: Association of breast cancer and cytokine gene polymorphism in Turkish women. Saudi Med J. 2007 Nov;28(11):1728-33.


All genotyping of tumor necrosis factor-alpha (TNF-alpha), tumor growth factor-beta1 (TGF-beta1), interleukin (IL)-10, IL-6, and interferon-gamma (IFN-gamma) experiments were performed using polymerase chain reaction sequence-specific primers.
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18472639 Manu KA, Kuttan G: Boerhaavia diffusa stimulates cell-mediated immune response by upregulating IL-2 and downregulating the pro-inflammatory cytokines and GM-CSF in B16F-10 metastatic melanoma bearing mice. J Exp Ther Oncol. 2008;7(1):17-29.


Levels of GM-CSF and pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-a were significantly lowered by Boerhaavia diffusa administration compared to metastatic control.
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17884446 Guo Z, Xia Z, Yuen VG, McNeill JH: Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Metabolism. 2007 Oct;56(10):1363-71.


Plasma and cardiac interleukin 6 and plasma tumor necrosis factor alpha (TNF-alpha) were assayed by enzyme-linked immunosorbent assay.
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18075866 Manu KA, Kuttan G: Effect of Punarnavine, an alkaloid from Boerhaavia diffusa, on cell-mediated immune responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice. Immunopharmacol Immunotoxicol. 2007;29(3-4):569-86.


Peaks of pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-alpha were significantly lowered by Punarnavine administration compared to metastatic control.
1(0,0,0,1) Details
18569082 Raphael TJ, Kuttan G: Effect of naturally occurring triterpenoids ursolic acid and glycyrrhizic acid on the cell-mediated immune responses of metastatic tumor-bearing animals. Immunopharmacol Immunotoxicol. 2008;30(2):243-55.


The highly elevated level of IL-6 (370.1 pg/ml) in control animals was also reduced by the treatment of glycyrrhizic acid (313 pg/ml) and ursolic acid (299 pg/ml).
1(0,0,0,1) Details
17988266 Coppo R, Amore A, Chiesa M, Lombardo F, Cirina P, Andrulli S, Passerini P, Conti G, Peruzzi L, Giraudi R, Messina M, Segoloni G, Ponticelli C: Serological and genetic factors in early recurrence of IgA nephropathy after renal transplantation. Clin Transplant. 2007 Nov-Dec;21(6):728-37.


METHODS: Sixty-one transplanted patients who had IgAN as an original disease (30 with biopsy-proved early recurrence, median 2.9 yr post-transplant), and 120 controls, were investigated for aberrantly glycosylated IgA1, IgA binding to mesangial matrix, macromolecular IgA (IgA/fibronectin and uteroglobulin/IgA/fibronectin complexes), and polymorphisms of cytokines [tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), IL-6, interferon gamma and transforming growth factor beta 1] and renin-angiotensin system (angiotensinogen converting enzyme, angiotensin II receptor 1, and angiotensinogen) genes.
1(0,0,0,1) Details
20305143 Dickinson AM, Pearce KF, Norden J, O'Brien SG, Holler E, Bickeboller H, Balavarca Y, Rocha V, Kolb HJ, Hromadnikova I, Sedlacek P, Niederwieser D, Brand R, Ruutu T, Apperley J, Szydlo R, Goulmy E, Siegert W, de Witte T, Gratwohl A: Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. Haematologica. 2010 Mar 19.


DESIGN AND METHODS: In this study, we assessed the effect of single nucleotide polymorphisms in genes for interleukin 1 receptor antagonist (IL1RN), interleukin (IL) 4 (IL4), IL6, IL10, interferon (IFN) IFNG, tumor necrosis factor (TNF) and cell surface receptors TNF receptor II (TNFRSFIB), vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) in a homogeneous cohort of 228 HLA identical sibling transplantations for chronic myeloid leukemia.
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