| Name | acetyl CoA carboxylase 1 |
|---|---|
| Synonyms | ACAC; ACACA; ACACA protein; ACC; ACC alpha; ACC1; ACCA; ACCalpha… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19190759 | Castle JC, Hara Y, Raymond CK, Garrett-Engele P, Ohwaki K, Kan Z, Kusunoki J, Johnson JM: ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]. PLoS One. 2009;4(2):e4369. Epub 2009 Feb 3. carboxylases ACC1 and ACC2 catalyze the carboxylation of to regulating fatty-acid synthesis and oxidation, and are potential targets for treatment of metabolic syndrome. |
4(0,0,0,4) | Details |
| 18381287 | Ronnebaum SM, Joseph JW, Ilkayeva O, Burgess SC, Lu D, Becker TC, Sherry AD, Newgard CB: Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of rather than lipid metabolism. J Biol Chem. 2008 May 23;283(21):14248-56. Epub 2008 Apr 1. |
4(0,0,0,4) | Details |
| 19805143 | Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B, Wakil SJ: aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17576-81. Epub 2009 Sep 24. |
3(0,0,0,3) | Details |
| 20154153 | Lengi AJ, Corl BA: Factors influencing the differentiation of bovine preadipocytes in vitro. J Anim Sci. 2010 Feb 12. This differentiation medium also increased mRNA expression of aP2, PPARgamma, and ACCalpha 180-, 7-, and 3-fold, respectively, compared to undifferentiated control cells (P < 0.05). |
3(0,0,0,3) | Details |
| 19411549 | Han C, Wang J, Li L, Zhang Z, Wang L, Pan Z: The role of insulin and in goose primary hepatocyte triglyceride accumulation. J Exp Biol. 2009 May;212(Pt 10):1553-8. Compared with the control group, 100 and 150 nmol l (-1) insulin increased TG accumulation, acetyl-CoA carboxylase-alpha (ACCalpha) and fatty acid synthase (FAS) activity, and the mRNA levels of sterol regulatory element-binding protein-1 (SREBP-1), FAS and ACCalpha genes. |
3(0,0,0,3) | Details |
| 19263251 | Ruenwai R, Cheevadhanarak S, Laoteng K: Overexpression of carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha. Mol Biotechnol. 2009 Jul;42(3):327-32. Epub 2009 Mar 5. According to the amino acid sequence homology and the conserved structural organization of the biotin carboxylase, carboxyl carrier protein, and carboxyl transferase domains, the cloned gene was characterized as a multi-domain ACC1 protein. |
2(0,0,0,2) | Details |
| 17671740 | Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada M, Yada R, Harada N, Takayanagi R, Nakamuta M: Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 2007 Sep;20(3):351-8. The target genes for real-time PCR analysis were as follows: acetyl-CoA carboxylase (ACC) 1, ACC2, fatty acid synthase (FAS), sterol regulatory element-binding protein 1c (SREBP-1c), and adipose differentiation-related protein (ADRP) for evaluation of de novo synthesis and uptake of fatty acids; carnitine palmitoyltransferase 1a; (CPT1a), long-chain acyl-CoA dehydrogenase (LCAD), long-chain L-3-hydroxyacylcoenzyme A dehydrogenase alpha (HADHalpha), uncoupling protein 2 (UCP2), straight-chain acyl-CoA oxidase (ACOX), branched-chain acyl-CoA oxidase (BOX), cytochrome P450 2E1 (CYP2E1), CYP4A11, and peroxisome proliferator-activated receptor (PPAR) alpha for oxidation in the mitochondria, peroxisomes and microsomes; superoxide dismutase (SOD), catalase, and glutathione synthetase (GSS) for antioxidant pathways; and diacylglycerol O-acyltransferase 1 (DGAT1), PPARgamma, and hormone-sensitive lipase (HSL) for triglyceride synthesis and catalysis. |
2(0,0,0,2) | Details |
| 17477831 | Liu Y, Zalameda L, Kim KW, Wang M, McCarter JD: Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based assay and a fluorescence polarization-based ADP Assay for high-throughput screening. Assay Drug Dev Technol. 2007 Apr;5(2):225-35. carboxylase (ACC) enzymes exist as two isoforms, ACC1 and ACC2, which play critical roles in fatty acid biosynthesis and oxidation. |
2(0,0,0,2) | Details |
| 19049388 | Li Y, Kaur H, Oakley MG: Probing the recognition properties of the antiparallel coiled coil motif from PKN by protein grafting. Biochemistry. 2008 Dec 23;47(51):13564-72. The crystal structure of RhoA with the N-terminal ACC motif (PKN-ACC1) is unusual in that these proteins interact through two distinct surfaces. |
2(0,0,0,2) | Details |
| 18485240 | Germani D, Puglianiello A, Cianfarani S: Uteroplacental insufficiency down regulates insulin receptor and affects expression of key enzymes of long-chain fatty acid (LCFA) metabolism in skeletal muscle at birth. Cardiovasc Diabetol. 2008 May 18;7:14. Muscle of the posterior limb was dissected at birth and processed by real-time RT-PCR to analyze the expression of insulin receptor, ACCalpha, ACCbeta (acetyl-CoA carboxylase alpha and beta subunits), ACS (acyl-CoA synthase), AMPK (AMP-activated protein kinase, alpha2 catalytic subunit), CPT1B palmitoyltransferase-1 beta subunit), MCD (malonyl-CoA decarboxylase) in 14 sham and 8 IUGR pups. |
2(0,0,0,2) | Details |
| 19519866 | Schreurs M, van Dijk TH, Gerding A, Havinga R, Reijngoud DJ, Kuipers F: Soraphen, an inhibitor of the carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet. Diabetes Obes Metab. 2009 Oct;11(10):987-91. Epub 2009 Jun 10. AIM: Inhibition of the carboxylase (ACC) system, consisting of the isozymes ACC1 and ACC2, may be beneficial for treatment of insulin resistance and/or obesity by interfering with de novo lipogenesis and beta-oxidation. |
2(0,0,0,2) | Details |
| 19156225 | Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, Ohta M, Kato N, Sasazuki T, Shirasawa S: Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. PLoS One. 2009;4(1):e4240. Epub 2009 Jan 21. Of interest is the down-regulation of fatty acid metabolism-related molecules, including acetyl-CoA carboxylase (ACC)-1, ACC-2 and fatty acid synthase in the liver of KRAP (-/-) mice, which could in part account for the metabolic phenotype in KRAP (-/-) mice. |
1(0,0,0,1) | Details |
| 17449569 | Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR: downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J Nutr. 2007 May;137(5):1127-31. SREBP-1 is also a transcription factor for lipogenic genes, such as desaturase1 (SCD1), acyltransferase (GPAT), and acetyl-CoA carboxylase (ACC) 1, and ACC2. |
1(0,0,0,1) | Details |
| 20041784 | Cho K, Kim SJ, Park SH, Kim S, Park T: Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food. 2009 Dec;12(6):1293-301. Chronic alcohol consumption up-regulated the hepatic expression of genes involved in inflammation, fatty acid synthesis, and metabolism, including tumor necrosis factor alpha (TNFalpha), liver X receptor alpha (LXRalpha), sterol regulatory element-binding protein (SREBP)-1c, fatty acid synthase, acetyl-coenzyme A carboxylase alpha (ACC), stearoyl-coenzyme A desaturase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), and low-density lipoprotein receptor (LDLR). |
1(0,0,0,1) | Details |
| 19427916 | Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8. The mRNA levels of malic enzyme (ME), ATP-citrate lyase (ACL), acetyl-CoA carboxylase alpha (ACCalpha), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1) and thyroid hormone responsive Spot 14 (Spot 14) declined in response to fasting. |
1(0,0,0,1) | Details |
| 18842111 | Ouadda AB, Levy E, Ziv E, Lalonde G, Sane AT, Delvin E, Elchebly M: Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus. Biosci Rep. 2009 Jun 15;29(5):283-92. Our investigation provided evidence that the development of insulin resistance/diabetic state in P. obesus is accompanied by (i) body weight gain and hyperlipidaemia; (ii) elevations of hepatic ACC-Ser79 phosphorylation and ACC protein levels; (iii) a rise in the gene expression of cytosolic ACC1 concomitant with invariable mitochondrial ACC2; (iv) an increase in hepatic AMPKalpha-Thr172 phosphorylation and protein expression without any modification in the calculated ratio of phospho-AMPKalpha to total AMPKalpha; (v) a stimulation in ACC activity despite increased AMPKalpha phosphorylation and protein expression; and (vi) a trend of increase in mRNA levels of key lipogenic enzymes [SCD-1 (stearoyl- desaturase-1), mGPAT (mitochondrial isoform of acyltransferase) and FAS (FA synthase)] and transcription factors [SREBP-1 (sterol-regulatory-element-binding protein-1) and ChREBP (carbohydrate responsive element-binding protein)]. |
1(0,0,0,1) | Details |
| 19853443 | Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A: (4-Piperidinyl)-piperazine: a new platform for carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8. Epub 2009 Oct 8. The inhibition of ACC has demonstrated promising therapeutic potential for treating obesity and type 2 diabetes mellitus in transgenic mice and preclinical animal models. We describe herein the synthesis and structure-activity relationships of a series of disubstituted (4-piperidinyl)-piperazine derivatives as a new platform for ACC1/2 non-selective inhibitors. |
1(0,0,0,1) | Details |
| 19727214 | Huo M, Zang HL, Zhang DJ, Wang B, Wu J, Zhang XY, Chen LH, Li J, Yang JC, Guan YF: [Role of increased activity of carbohydrate response element binding protein in excessive lipid accumulation in the liver of type 2 diabetic db/db mouse]. Beijing Da Xue Xue Bao. 2009 Jun 18;41(3):307-12. The expressions of ChREBP and its target genes including acetyl-coenzyme A carboxylase 1 (Acc-1), fatty acid synthase (Fas), acyltransferase (Gpat) were analyzed by Real-time PCR and Western blot. |
1(0,0,0,1) | Details |
| 17984485 | Jakus PB, Sandor A, Janaky T, Farkas V: Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of accumulation in BAT during reacclimation. J Lipid Res. 2008 Feb;49(2):332-9. Epub 2007 Nov 5. Importantly, in BAT, only the phosphorylation of the ACC1 isoenzyme was enhanced, whereas that of ACC2 remained unchanged. |
1(0,0,0,1) | Details |
| 20036965 | Wang C, Rajput S, Watabe K, Liao DF, Cao D: carboxylase-a as a novel target for cancer therapy. Front Biosci (Schol Ed). 2010 Jan 1;2:515-26. ACC-alpha (ACCA, also termed ACC1) and ACC-beta (ACCB, also designated ACC2). |
1(0,0,0,1) | Details |
| 18082128 | MacDonald MJ, Dobrzyn A, Ntambi J, Stoker SW: The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells. Arch Biochem Biophys. 2008 Feb 15;470(2):153-62. Epub 2007 Dec 3. We found that ACC1, the isoform seen in lipogenic tissues, is the only isoform present in human and rat pancreatic islets and INS-1 832/13 cells. |
1(0,0,0,1) | Details |
| 19251398 | Milanski M, Souza KL, Reis SR, Feres NH, de Souza LM, Arantes VC, Carneiro EM, Boschero AC, Reis MA, Latorraca MQ: Soybean diet modulates carboxylase expression in livers of rats recovering from early-life malnutrition. Nutrition. 2009 Jul-Aug;25(7-8):774-81. Epub 2009 Feb 28. CONCLUSION: Thus, the soybean diet reduced the liver lipid concentration through downregulation of the ACC gene and protein expressions rather than by phosphorylation status, which possibly resulted in decreased lipogenesis and increased beta-oxidation. Hepatic acetyl-coenzyme A carboxylase (ACC)-alpha and ACCbeta mRNA expression was markedly lower in the LS and CS rats than in the LC and CC rats. |
1(0,0,0,1) | Details |
| 18975056 | Han C, Wang J, Li L, Wang L, Zhang Z: The role of LXR alpha in goose primary hepatocyte lipogenesis. Mol Cell Biochem. 2009 Feb;322(1-2):37-42. Epub 2008 Oct 31. Triglyceride (TG) accumulation, acetyl-CoA carboxylase alpha (ACC alpha) and fatty acid synthase (FAS) activities, and gene expression levels of LXR alpha, sterol regulatory element-binding proteins-1 (SREBP-1), FAS, ACC alpha and lipoprotein lipase (LPL) were measured in primary hepatocytes. |
1(0,0,0,1) | Details |
| 19383549 | Wang PH, Ko YH, Chin HJ, Hsu C, Ding ST, Chen CY: The effect of feed restriction on expression of hepatic lipogenic genes in broiler chickens and the function of SREBP1. Comp Biochem Physiol B Biochem Mol Biol. 2009 Aug;153(4):327-31. Epub 2009 Apr 19. The acetyl coenzyme A carboxylase (alpha) (ACC (alpha)) mRNA was also significantly reduced by the SREBP1 siRNA treatment, suggesting that SREBP1 can upregulate the expression of this lipogenic gene. |
1(0,0,0,1) | Details |
| 18795349 | Praveena G, Kolandaivel P: Structural and dynamical studies of all-trans and all-cis cyclo [(1R,3S)-gamma-Acc-Gly] 3 peptides. J Mol Model. 2008 Dec;14(12):1147-57. Epub 2008 Sep 16. The quantum chemical and molecular dynamics studies have been performed to infer the structural changes of all-trans and all-cis forms of cyclo [(1R,3S)-3-aminocyclohexanecarboxylicacid (gamma-Acc)-alpha- (Gl y)](3) hexapeptide. |
1(0,0,0,1) | Details |
| 20057367 | Anavi S, Ilan E, Tirosh O, Madar Z: Infusion of a Lipid Emulsion Modulates AMPK and Related Proteins in Rat Liver, Muscle, and Adipose Tissues. Obesity (Silver Spring). 2010 Jan 7. Hepatic mRNA levels of ACCalpha, PPARalpha, AdipoR1, AdipoR2, and sterol regulatory element-binding protein-1c (SREBP1c) were also reduced after LE infusion. |
1(0,0,0,1) | Details |
| 19552511 | Corbett JW: Review of recent carboxylase inhibitor patents: mid-2007-2008. Expert Opin Ther Pat. 2009 Jul;19(7):943-56. Furthermore, published patents claim the discovery of ACC2 isoform selective and ACC1/2 non-selective inhibitors. |
1(0,0,0,1) | Details |
| 20219367 | Corbett JW, Freeman-Cook KD, Elliott R, Vajdos F, Rajamohan F, Kohls D, Marr E, Zhang H, Tong L, Tu M, Murdande S, Doran SD, Houser JA, Song W, Jones CJ, Coffey SB, Buzon L, Minich ML, Dirico KJ, Tapley S, McPherson RK, Sugarman E, Harwood HJ Jr, Esler W: Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8. Epub 2009 Apr 24. Utilizing HTS hits and structure-based drug discovery, a more rigid inhibitor was designed and led to the discovery of sub-micromolar, spirochromanone non-specific ACC inhibitors. |
1(0,0,0,1) | Details |
| 19842072 | Peng Y, Lei T, Yuan J, Chen X, Long Q, Zhan J, Lei P, Feng B, Yang Z: induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009 Oct 20. |
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| 20139635 | Zhao LF, Iwasaki Y, Zhe W, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y: Hormonal Regulation of Carboxylase Isoenzyme Gene Transcription. Endocr J. 2010 Feb 7. carboxylase (ACC), consisting of two isoenzymes ACC1 and ACC2, mediates the conversion from to and thus plays a key role for the regulation of lipogenesis. |
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| 19618481 | Kreuz S, Schoelch C, Thomas L, Rist W, Rippmann JF, Neubauer H: carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes. Diabetes Metab Res Rev. 2009 Sep;25(6):577-86. METHODS: ACC1 and ACC2 transcript levels were measured by quantitative real-time polymerase chain reaction in metabolically relevant tissues of Zucker fatty, Zucker diabetic fatty and Zucker lean control animals. |
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