Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19454504 Magdalan J, Ostrowska A, Piotrowska A, Izykowska I, Nowak M, Szelag A, Dziegiel P: Failure of benzylpenicillin, N-acetylcysteine and silibinin to reduce alpha-amanitin hepatotoxicity. In Vivo. 2009 May-Jun;23(3):393-9.


Cytotoxicity evaluation of cultured cells (MTT assay, extracellular lactate dehydrogenase activity) was performed at 12, 24 and 48 h of exposure to alpha-AMA and/or antidotes.
3(0,0,0,3) Details
19556115 Magdalan J, Ostrowska A, Piotrowska A, Gomulkiewicz A, Podhorska-Okolow M, Patrzalek D, Szelag A, Dziegiel P: Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin. Exp Toxicol Pathol. 2009 Jun 23.


Cytotoxicity evaluation of cultured cells using MTT assay and measurement of lactate dehydrogenase (LDH) activity was performed at 12, 24 and 48h of exposure to alpha-AMA and/or antidotes.
1(0,0,0,1) Details
17584670 Aytekin V: Update on ACC/ESC criteria for acute ST-elevation myocardial infarction. Anadolu Kardiyol Derg. 2007 Jul;7 Suppl 1:14-5.


Although the old markers creatine kinase and the MB fraction, lactate dehydrogenase are also used for the diagnosis of acute MI, cardiac troponins are very sensitive and specific, and myoglobin is an early marker for acute MI.
1(0,0,0,1) Details
18201362 Bogunia-Kubik K, Mazur G, Wrobel T, Kuliczkowski K, Lange A: Interleukin-10 gene polymorphisms influence the clinical course of non-Hodgkin's lymphoma. Tissue Antigens. 2008 Feb;71(2):146-50.


In multivariate analyses, the AA homozygosity (OR = 6.33, P < 0.05) and ACC genotype (OR = 3.57, P = 0.05) appeared as independent risk factors of more aggressive manifestation of NHL in addition to the elevated lactate dehydrogenase 480 level.
1(0,0,0,1) Details
19523445 Cha SH, Lane MD: Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. Biochem Biophys Res Commun. 2009 Aug 14;386(1):212-6. Epub 2009 Jun 10.


All downstream effects of hypothalamic lactate are blocked by icv administered oxamate, a potent inhibitor of lactate dehydrogenase, thus verifying the central action of lactate.
1(0,0,0,1) Details