Protein Information

Name cAMP response element binding protein
Synonyms Active transcription factor CREB; CREB; CREB 1; CREB1; cAMP response element binding protein; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1 isoform B…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18434517 Wang H, Wu LJ, Zhang F, Zhuo M: Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008 Apr 23;28(17):4385-97.


Both AC1 and CaMKIV contribute to the regulation of FMRP by group I mGluRs probably through cAMP response element-binding protein activation.
1(0,0,0,1) Details
19436069 Wang H, Fukushima H, Kida S, Zhuo M: Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex. J Biol Chem. 2009 Jul 10;284(28):18953-62. Epub 2009 May 12.


CaMKIV contribute to the regulation of FMRP by Group I mGluRs probably through cyclic AMP-responsive element binding protein (CREB) activation, as manipulation of CaMKIV could simultaneously cause the change of CREB phosphorylation induced by Group I mGluR activation.
1(0,0,0,1) Details
18669938 Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW: Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. J Appl Physiol. 2008 Oct;105(4):1218-27. Epub 2008 Jul 31.

4(0,0,0,4) Details
19842072 Peng Y, Lei T, Yuan J, Chen X, Long Q, Zhan J, Lei P, Feng B, Yang Z: Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009 Oct 20.

4(0,0,0,4) Details
19784086 Cao H, Cui YH, Zhao ZQ, Cao XH, Zhang YQ: Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction of long-term potentiation in rats. Neurosci Bull. 2009 Oct;25(5):301-8.


METHODS: LTP of field potential was recorded in ACC slice and the expressions of phospho-ERK (pERK) and phospho-CREB (pCREB) were examined using immunohistochemistry method.
2(0,0,0,2) Details
19664651 Zhang XJ, Chen HL, Li Z, Zhang HQ, Xu HX, Sung JJ, Bian ZX: Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A (1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. Pharmacol Biochem Behav. 2009 Nov;94(1):88-97. Epub 2009 Aug 5.


Results: CRD-induced visceral pain as well as phosphorylated-extracellular signal-regulated protein kinase (p-ERK) and phospho-cAMP response element-binding protein (p-CREB) expression in the CNS structures of NMS rats were suppressed by NMDA receptor antagonist dizocilpine (MK-801) and ERK phosphorylation inhibitor U0126.
2(0,0,0,2) Details
19279268 Cao H, Gao YJ, Ren WH, Li TT, Duan KZ, Cui YH, Cao XH, Zhao ZQ, Ji RR, Zhang YQ: Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain. J Neurosci. 2009 Mar 11;29(10):3307-21.


Downstream, phosphorylation of cAMP response element binding protein (CREB) was induced in the rACC by formalin injection and by NMDA, AC and PKA activators in brain slices, which was suppressed by MEK inhibitors.
2(0,0,0,2) Details