Protein Information

Name interleukin 10
Synonyms B TCGF; B cell derived T cell growth factor; CSIF; Cytokine synthesis inhibitory factor; IL 10; IL10; IL10A; Interleukin 10…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18427872 Ates O, Hatemi G, Hamuryudan V, Topal-Sarikaya A: Tumor necrosis factor-alpha and interleukin-10 gene promoter polymorphisms in Turkish rheumatoid arthritis patients. Clin Rheumatol. 2008 Oct;27(10):1243-8. Epub 2008 Apr 22.

7(0,0,0,7) Details
20339193 Weng KP, Hsieh KS, Hwang YT, Huang SH, Lai TJ, Yuh YS, Hou YY, Lin CC, Huang SC, Chang CK, Lin MW, Ger LP: IL-10 Polymorphisms Are Associated With Coronary Artery Lesions in Acute Stage of Kawasaki Disease. Circ J. 2010 Mar 26.

7(0,0,0,7) Details
18447856 Cullinan MP, Westerman B, Hamlet SM, Palmer JE, Faddy MJ, Seymour GJ, Middleton PG, Taylor JJ: Progression of periodontal disease and interleukin-10 gene polymorphism. J Periodontal Res. 2008 Jun;43(3):328-33.

7(0,0,0,7) Details
18972297 Movahedi M, Mahdaviani SA, Rezaei N, Moradi B, Dorkhosh S, Amirzargar AA: IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma. J Asthma. 2008 Nov;45(9):790-4.

7(0,0,0,7) Details
18071881 Ates O, Musellim B, Ongen G, Topal-Sarikaya A: Interleukin-10 and tumor necrosis factor-alpha gene polymorphisms in tuberculosis. J Clin Immunol. 2008 May;28(3):232-6.

6(0,0,0,6) Details
19249119 Rezaei N, Aghamohammadi A, Mahmoudi M, Shakiba Y, Kardar GA, Mahmoudi M, Moradi B, Amirzargar AA: Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency. Immunobiology. 2010;215(1):81-7. Epub 2009 Feb 26.

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18397303 Rosado S, Rua-Figueroa I, Vargas JA, Garcia-Laorden MI, Losada-Fernandez I, Martin-Donaire T, Perez-Chacon G, Rodriguez-Gallego C, Naranjo-Hernandez A, Ojeda-Bruno S, Citores MJ, Perez-Aciego P: Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands. Int J Immunogenet. 2008 Jun;35(3):235-42. Epub 2008 Apr 7.

6(0,0,0,6) Details
18201362 Bogunia-Kubik K, Mazur G, Wrobel T, Kuliczkowski K, Lange A: Interleukin-10 gene polymorphisms influence the clinical course of non-Hodgkin's lymphoma. Tissue Antigens. 2008 Feb;71(2):146-50.

6(0,0,0,6) Details
19295541 Oleksyk TK, Shrestha S, Truelove AL, Goedert JJ, Donfield SM, Phair J, Mehta S, O'Brien SJ, Smith MW: Extended IL10 haplotypes and their association with HIV progression to AIDS. Genes Immun. 2009 Jun;10(4):309-22. Epub 2009 Mar 19.

5(0,0,0,5) Details
17389013 Beretta L, Cappiello F, Barili M, Scorza R: Proximal interleukin-10 gene polymorphisms in Italian patients with systemic sclerosis. Tissue Antigens. 2007 Apr;69(4):305-12.

5(0,0,0,5) Details
18705845 Mirahmadian M, Kalantar F, Heidari G, Safdarian L, Mansouri R, Amirzargar AA: Association of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in Iranian patients with pre-eclampsia. Am J Reprod Immunol. 2008 Aug;60(2):179-85.

5(0,0,0,5) Details
19210338 Hu KF, Huang KC, Ho YP, Lin YC, Ho KY, Wu YM, Yang YH, Tsai CC: Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. J Periodontal Res. 2009 Jun;44(3):378-85. Epub 2009 Feb 6.

5(0,0,0,5) Details
18230105 Reichert S, Machulla HK, Klapproth J, Zimmermann U, Reichert Y, Glaser CH, Schaller HG, Stein J, Schulz S: The interleukin-10 promoter haplotype ATA is a putative risk factor for aggressive periodontitis. J Periodontal Res. 2008 Feb;43(1):40-7.

5(0,0,0,5) Details
19299022 Alseth EH, Nakkestad HL, Aarseth J, Gilhus NE, Skeie GO: Interleukin-10 promoter polymorphisms in myasthenia gravis. . J Neuroimmunol. 2009 May 29;210(1-2):63-6. Epub 2009 Mar 18.

4(0,0,0,4) Details
18493769 Ates O, Musellim B, Ongen G, Topal-Sarikaya A: Association between 'interleukin' 10 gene (IL10) polymorphisms and systemic sclerosis with interstitial lung involvement. Rheumatol Int. 2008 Sep;28(11):1123-6. Epub 2008 May 21.

4(0,0,0,4) Details
19470040 Javor J, Chmurova N, Parnicka Z, Ferencik S, Grosse-Wilde H, Buc M, Svecova D: TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population. J Eur Acad Dermatol Venereol. 2010 Jan;24(1):65-8. Epub 2009 Apr 8.

4(0,0,0,4) Details
19082598 Sobkowiak A, Lianeri M, Wudarski M, Lacki JK, Jagodzinski PP: Genetic variation in the interleukin-10 gene promoter in Polish patients with systemic lupus erythematosus. Rheumatol Int. 2009 Jun;29(8):921-5. Epub 2008 Dec 10.

4(0,0,0,4) Details
19673019 Sanchez R, Levy E, Costea F, Sinnett D: IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. World J Gastroenterol. 2009 Aug 14;15(30):3776-82.

4(0,0,0,4) Details
17965799 Gonullu G, Basturk B, Evrensel T, Oral B, Gozkaman A, Manavoglu O: Association of breast cancer and cytokine gene polymorphism in Turkish women. Saudi Med J. 2007 Nov;28(11):1728-33.


All genotyping of tumor necrosis factor-alpha (TNF-alpha), tumor growth factor-beta1 (TGF-beta1), interleukin (IL)-10, IL-6, and interferon-gamma (IFN-gamma) experiments were performed using polymerase chain reaction sequence-specific primers.
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18457043 Pogoda TV, Marsheva OV, Kostin PA, Maksimov VN, Kulikov IV, Openko TG, Simonova GI, Voyevoda MI, Generozov EV, Govorun VM: Association of haplotypes of interleukin-10 gene with the risk of cancer. Bull Exp Biol Med. 2007 Sep;144(3):385-9.

4(0,0,0,4) Details
17988266 Coppo R, Amore A, Chiesa M, Lombardo F, Cirina P, Andrulli S, Passerini P, Conti G, Peruzzi L, Giraudi R, Messina M, Segoloni G, Ponticelli C: Serological and genetic factors in early recurrence of IgA nephropathy after renal transplantation. Clin Transplant. 2007 Nov-Dec;21(6):728-37.


METHODS: Sixty-one transplanted patients who had IgAN as an original disease (30 with biopsy-proved early recurrence, median 2.9 yr post-transplant), and 120 controls, were investigated for aberrantly glycosylated IgA1, IgA binding to mesangial matrix, macromolecular IgA (IgA/fibronectin and uteroglobulin/IgA/fibronectin complexes), and polymorphisms of cytokines [tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), IL-6, interferon gamma and transforming growth factor beta 1] and renin-angiotensin system (angiotensinogen converting enzyme, angiotensin II receptor 1, and angiotensinogen) genes.
3(0,0,0,3) Details
18612930 Willeke P, Gaubitz M, Schotte H, Becker H, Domschke W, Schluter B: The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome. Scand J Rheumatol. 2008 Jul-Aug;37(4):293-9.

3(0,0,0,3) Details
18408074 Thakkinstian A, Dmitrienko S, Gerbase-Delima M, McDaniel DO, Inigo P, Chow KM, McEvoy M, Ingsathit A, Trevillian P, Barber WH, Attia J: Association between cytokine gene polymorphisms and outcomes in renal transplantation: a meta-analysis of individual patient data. Nephrol Dial Transplant. 2008 Sep;23(9):3017-23. Epub 2008 Apr 11.


We therefore conducted a systematic review, with individual patient data (IPD) where possible, to determine the association between cytokine polymorphisms (TGF-beta1, TNF-alpha and IL-10) and outcomes after renal transplantation.
3(0,0,0,3) Details
20191386 Ates O, Dalyan L, Hatemi G, Hamuryudan V, Topal-Sarikaya A: Analyses of functional IL10 and TNF-alpha genotypes in Behcet's syndrome. . Mol Biol Rep. 2010 Feb 27.

3(0,0,0,3) Details
18619701 Morgan TR, Lambrecht RW, Bonkovsky HL, Chung RT, Naishadham D, Sterling RK, Fontana RJ, Lee WM, Ghany MG, Wright EC, O'Brien TR: DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial. J Hepatol. 2008 Oct;49(4):548-56. Epub 2008 Jun 5.


The percentage of patients who achieved SVR was determined for each genotype and for an IL10 promoter diplotype.
2(0,0,0,2) Details
20305143 Dickinson AM, Pearce KF, Norden J, O'Brien SG, Holler E, Bickeboller H, Balavarca Y, Rocha V, Kolb HJ, Hromadnikova I, Sedlacek P, Niederwieser D, Brand R, Ruutu T, Apperley J, Szydlo R, Goulmy E, Siegert W, de Witte T, Gratwohl A: Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. Haematologica. 2010 Mar 19.


DESIGN AND METHODS: In this study, we assessed the effect of single nucleotide polymorphisms in genes for interleukin 1 receptor antagonist (IL1RN), interleukin (IL) 4 (IL4), IL6, IL10, interferon (IFN) IFNG, tumor necrosis factor (TNF) and cell surface receptors TNF receptor II (TNFRSFIB), vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) in a homogeneous cohort of 228 HLA identical sibling transplantations for chronic myeloid leukemia.
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