| Name | ChREBP |
|---|---|
| Synonyms | CHREBP; Mlx interactor; Carbohydrate response element binding protein; MIO; MLX interacting protein like; MLXIPL; MONDOB; Mondo family member B… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19727214 | Huo M, Zang HL, Zhang DJ, Wang B, Wu J, Zhang XY, Chen LH, Li J, Yang JC, Guan YF: [Role of increased activity of carbohydrate response element binding protein in excessive lipid accumulation in the liver of type 2 diabetic db/db mouse]. Beijing Da Xue Xue Bao. 2009 Jun 18;41(3):307-12. |
10(0,0,0,10) | Details |
| 19427916 | Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8. |
5(0,0,0,5) | Details |
| 18292813 | Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C: ChREBP, but not LXRs, is required for the induction of -regulated genes in mouse liver. J Clin Invest. 2008 Mar;118(3):956-64. The transcription factor carbohydrate-responsive element-binding protein (ChREBP) has emerged as a central regulator of lipid synthesis in liver because it is required for -induced expression of the glycolytic enzyme liver-pyruvate kinase (L-PK) and acts in synergy with SREBP to induce lipogenic genes such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). |
4(0,0,0,4) | Details |
| 19954950 | Kim HJ, Yuan J, Norris K, Vaziri ND: High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney. J Nutr Biochem. 2009 Nov 30. The CRF group consuming a regular diet exhibited growth retardation; azotemia; proteinuria; glomerulosclerosis; tubulointerstitial injury; heavy lipid accumulation in the remnant kidney; up-regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), ATP-binding cassette transporter-1 (ABCA1), liver X receptor (LXR) alpha/beta, carbohydrate-responsive element binding protein (ChREBP) and acyl- carboxylase (ACC); and down-regulation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha), palmitoyltransferase-1 (CPT1) and liver-type fatty acid binding protein (L-FABP). |
2(0,0,0,2) | Details |
| 19878707 | Cho KH, Kim HJ, Kamanna VS, Vaziri ND: improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28. RESULTS: CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl- carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG- reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A. |
2(0,0,0,2) | Details |
| 20139635 | Zhao LF, Iwasaki Y, Zhe W, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y: Hormonal Regulation of Carboxylase Isoenzyme Gene Transcription. Endocr J. 2010 Feb 7. We also examined the roles of the insulin and/or -regulated transcriptional such as SREBP1c, LXRalpha/beta, and ChREBP on each promoter of the ACC genes. |
2(0,0,0,2) | Details |
| 18842111 | Ouadda AB, Levy E, Ziv E, Lalonde G, Sane AT, Delvin E, Elchebly M: Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus. Biosci Rep. 2009 Jun 15;29(5):283-92. Our investigation provided evidence that the development of insulin resistance/diabetic state in P. obesus is accompanied by (i) body weight gain and hyperlipidaemia; (ii) elevations of hepatic ACC-Ser79 phosphorylation and ACC protein levels; (iii) a rise in the gene expression of cytosolic ACC1 concomitant with invariable mitochondrial ACC2; (iv) an increase in hepatic AMPKalpha-Thr172 phosphorylation and protein expression without any modification in the calculated ratio of phospho-AMPKalpha to total AMPKalpha; (v) a stimulation in ACC activity despite increased AMPKalpha phosphorylation and protein expression; and (vi) a trend of increase in mRNA levels of key lipogenic enzymes [SCD-1 (stearoyl- desaturase-1), mGPAT (mitochondrial isoform of acyltransferase) and FAS (FA synthase)] and transcription factors [SREBP-1 (sterol-regulatory-element-binding protein-1) and ChREBP (carbohydrate responsive element-binding protein)]. |
1(0,0,0,1) | Details |
| 19223519 | Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, Lane M, Norman RJ: Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009 May;94(5):1533-40. Epub 2009 Feb 17. Granulosa and cumulus cells were analyzed for mRNA expression of insulin signaling components (IRS-2 and Glut4), -regulated genes (ChREBP, ACC, and FAS) and insulin-regulated genes (SREBP-1, CD36, and SR-BI) associated with obesity/insulin resistance. |
1(0,0,0,1) | Details |
| 18794597 | Morgan K, Uyuni A, Nandgiri G, Mao L, Castaneda L, Kathirvel E, French SW, Morgan TR: Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2008 Sep;20(9):843-54. Hepatic expression of sterol regulatory element-binding protein-1c, carbohydrate response element-binding protein, liver X receptor-alpha, carboxylase (ACC), and fatty acid synthase (FAS) decreased during fasting in SF and HF mice; however, FAS expression and protein content were higher in the liver of fasted HF mice than of fasted SF mice. |
1(0,0,0,1) | Details |