| Name | SREBP1 |
|---|---|
| Synonyms | SREBF 1; SREBF1; SREBP 1; SREBP1; Sterol regulatory element binding protein 1; Sterol regulatory element binding transcription factor 1; Sterol regulatory element binding protein 1s; Sterol regulatory element binding transcription factor 1s |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19383549 | Wang PH, Ko YH, Chin HJ, Hsu C, Ding ST, Chen CY: The effect of feed restriction on expression of hepatic lipogenic genes in broiler chickens and the function of SREBP1. Comp Biochem Physiol B Biochem Mol Biol. 2009 Aug;153(4):327-31. Epub 2009 Apr 19. |
6(0,0,0,6) | Details |
| 17449569 | Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR: downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J Nutr. 2007 May;137(5):1127-31. |
5(0,0,0,5) | Details |
| 18975056 | Han C, Wang J, Li L, Wang L, Zhang Z: The role of LXR alpha in goose primary hepatocyte lipogenesis. Mol Cell Biochem. 2009 Feb;322(1-2):37-42. Epub 2008 Oct 31. Triglyceride (TG) accumulation, acetyl-CoA carboxylase alpha (ACC alpha) and fatty acid synthase (FAS) activities, and gene expression levels of LXR alpha, sterol regulatory element-binding proteins-1 (SREBP-1), FAS, ACC alpha and lipoprotein lipase (LPL) were measured in primary hepatocytes. |
4(0,0,0,4) | Details |
| 19411549 | Han C, Wang J, Li L, Zhang Z, Wang L, Pan Z: The role of insulin and in goose primary hepatocyte triglyceride accumulation. J Exp Biol. 2009 May;212(Pt 10):1553-8. Compared with the control group, 100 and 150 nmol l (-1) insulin increased TG accumulation, acetyl-CoA carboxylase-alpha (ACCalpha) and fatty acid synthase (FAS) activity, and the mRNA levels of sterol regulatory element-binding protein-1 (SREBP-1), FAS and ACCalpha genes. |
4(0,0,0,4) | Details |
| 19418221 | Saito M, Chakraborty G, Mao RF, Vadasz C, Saito M: Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain. Neurochem Res. 2009 Nov;34(11):1945-54. Epub 2009 May 6. Presently, we examined developmental changes in the levels and cellular localization of FAS and ACC, and their putative regulators, sterol-regulatory element-binding protein (SREBP)-1 and AMP-activated protein kinase (AMPK) in the mouse brain. |
2(0,0,0,2) | Details |
| 17624300 | Ren S, Li X, Rodriguez-Agudo D, Gil G, Hylemon P, Pandak WM: Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun. 2007 Sep 7;360(4):802-8. Epub 2007 Jul 6. Coincidently, 25HC3S inhibited the activation of sterol regulatory element binding proteins (SREBPs), suggesting that inhibition of cholesterol biosynthesis occurred via blocking SREBP-1 activation, and subsequently by inhibiting the expression of HMG reductase. 25HC3S also decreased SREBP-1 mRNA levels and inhibited the expression of target genes encoding acetyl CoA carboxylase-1 (ACC-1) and fatty acid synthase (FAS). |
2(0,0,0,2) | Details |
| 18614621 | Zhou Y, Zhang X, Chen L, Wu J, Dang H, Wei M, Fan Y, Zhang Y, Zhu Y, Wang N, Breyer MD, Guan Y: Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am J Physiol Renal Physiol. 2008 Sep;295(3):F662-71. Epub 2008 Jul 9. Four genes involved in fatty acid biosynthesis, Acc, FAS, ELOVL 2, and ELOVL6, and three critical for triglyceride biosynthesis, Gpam, Agpat 3, and Dgat 1, were significantly upregulated, whereas two genes involved in fatty acid oxidation, Dci and MCAD, were downregulated. Expression of several genes in sterol-regulatory element-binding protein (SREBP)-1 activation was also aberrantly altered in nephrotic livers. |
2(0,0,0,2) | Details |
| 19427916 | Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8. In contrast, ChREBP and sterol regulatory element binding protein-1 (SREBP-1) mRNA levels decreased during fasting and increased with refeeding. |
1(0,0,0,1) | Details |
| 19878707 | Cho KH, Kim HJ, Kamanna VS, Vaziri ND: improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28. RESULTS: CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl- carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG- reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A. |
1(0,0,0,1) | Details |
| 19727214 | Huo M, Zang HL, Zhang DJ, Wang B, Wu J, Zhang XY, Chen LH, Li J, Yang JC, Guan YF: [Role of increased activity of carbohydrate response element binding protein in excessive lipid accumulation in the liver of type 2 diabetic db/db mouse]. Beijing Da Xue Xue Bao. 2009 Jun 18;41(3):307-12. In contrast, another lipogenic transcription factor, sterol regulatory element binding protein-1 (SREBP-1), remained unchanged. |
1(0,0,0,1) | Details |
| 18842111 | Ouadda AB, Levy E, Ziv E, Lalonde G, Sane AT, Delvin E, Elchebly M: Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus. Biosci Rep. 2009 Jun 15;29(5):283-92. Our investigation provided evidence that the development of insulin resistance/diabetic state in P. obesus is accompanied by (i) body weight gain and hyperlipidaemia; (ii) elevations of hepatic ACC-Ser79 phosphorylation and ACC protein levels; (iii) a rise in the gene expression of cytosolic ACC1 concomitant with invariable mitochondrial ACC2; (iv) an increase in hepatic AMPKalpha-Thr172 phosphorylation and protein expression without any modification in the calculated ratio of phospho-AMPKalpha to total AMPKalpha; (v) a stimulation in ACC activity despite increased AMPKalpha phosphorylation and protein expression; and (vi) a trend of increase in mRNA levels of key lipogenic enzymes [SCD-1 (stearoyl- desaturase-1), mGPAT (mitochondrial isoform of acyltransferase) and FAS (FA synthase)] and transcription factors [SREBP-1 (sterol-regulatory-element-binding protein-1) and ChREBP (carbohydrate responsive element-binding protein)]. |
1(0,0,0,1) | Details |
| 19231861 | Kim JH, Jeong WS, Kim IH, Kim HJ, Kim SH, Kang GH, Lee HG, Yoon HG, Ham HJ, Kim YJ: Effect of an oil byproduct from (CLA) purification on CLA accumulation and lipogenic gene expression in broilers. J Agric Food Chem. 2009 Mar 25;57(6):2397-404. CLA supplementation also induced lipogenesis in the livers of the broilers, and it significantly increased the relative mRNA levels of sterol regulatory element binding protein 1 (SREBP1), as well as its target genes: fatty acid synthase (FAS) and carboxylase (ACC) (p < 0.05). |
1(0,0,0,1) | Details |
| 19223519 | Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, Lane M, Norman RJ: Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009 May;94(5):1533-40. Epub 2009 Feb 17. Granulosa and cumulus cells were analyzed for mRNA expression of insulin signaling components (IRS-2 and Glut4), -regulated genes (ChREBP, ACC, and FAS) and insulin-regulated genes (SREBP-1, CD36, and SR-BI) associated with obesity/insulin resistance. |
1(0,0,0,1) | Details |