Protein Information

Name chemokines
Synonyms CXCL12; Chemokine; Chemokine ligand 12; PBSF; Pre B cell growth stimulating factor; SCYB12; SDF 1 alpha; SDF 1 beta…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19020745 Zushi Y, Noguchi K, Hashitani S, Sakurai K, Segawa E, Takaoka K, Toyohara Y, Tanaka N, Kishimoto H, Urade M: Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck. Int J Oncol. 2008 Dec;33(6):1133-9.


Adenoid cystic carcinoma (ACC) may acquire a chemokine-mediated mechanism during the process of metastasis.
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19141064 Shang ZJ, Liu K, Liang de F: Expression of beta2-adrenergic receptor in oral squamous cell carcinoma. . J Oral Pathol Med. 2009 Apr;38(4):371-6. Epub 2008 Dec 30.


BACKGROUND: It has been speculated that chemokines and neurotransmitters might be involved in the organ-specific development of metastases because cancer metastasis is similar to the regulation of migratory activity in leukocytes.
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18752985 Shang ZJ, Liu K, Shao Z: Expression of chemokine receptor CCR7 is associated with cervical lymph node metastasis of oral squamous cell carcinoma. Oral Oncol. 2009 Jun;45(6):480-5. Epub 2008 Aug 26.


Tumor cell migration and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors.
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17578764 Kanczkowski W, Morawietz H, Ziegler CG, Funk RH, Schmitz G, Zacharowski K, Mohn CE, Ehrhart-Bornstein M, Bornstein SR: Pam3CSK4 and LTA-TLRs ligands associated with microdomains induce IL8 production in human adrenocortical cancer cells. Horm Metab Res. 2007 Jun;39(6):457-60.


CXC chemokine-dependent immune cell infiltration into adrenocortical carcinomas (ACC), which correlates with poor prognosis, is a common phenomenon.
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