Protein Information

Name leucocyte antigen
Synonyms Cell surface glycoprotein; MHC class I antigen; MHC class II antigen; DR5; Leucocyte antigen B; DR 5; DRB 1; DRB1…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
20160632 Gatanaga H, Ode H, Hachiya A, Hayashida T, Sato H, Takiguchi M, Oka S: Impact of human leukocyte antigen-B*51-restricted cytotoxic T-lymphocyte pressure on mutation patterns of nonnucleoside reverse transcriptase inhibitor resistance. AIDS. 2010 Mar 13;24(5):F15-22.

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18363780 Negi S, Ivanchenko MG, Muday GK: Ethylene regulates lateral root formation and auxin transport in Arabidopsis thaliana. Plant J. 2008 Jul;55(2):175-87. Epub 2008 Mar 19.


DR5-GUS reporter expression is also altered by ACC treatment, which is consistent with transport differences.
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18370849 Gatanaga H, Honda H, Oka S: Pharmacogenetic information derived from analysis of HLA alleles. Pharmacogenomics. 2008 Feb;9(2):207-14.


A large amount of pharmacogenetic information has, in particular, accumulated on the association between human leukocyte antigen (HLA) alleles and hypersensitivity to certain drugs.
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19624484 Kim KW, Kwon OJ, Kwon SY, Cho NS, Oh DJ: A new HLA-B*5124 variant, B*512402 allele, identified by sequence-based typing. Tissue Antigens. 2009 Sep;74(3):253-4. Epub 2009 Jul 13.

A novel human leukocyte antigen-B allele, officially named B*512402, was identified in a Korean bone marrow donor.
The B*512402 allele shows two nucleotide substitutions compared with B*512401 in exon 3 at codons 135 (GCG --> GCC) and 138 (ACC --> ACG) without any amino acid substitution.
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17409267 Kawase T, Akatsuka Y, Torikai H, Morishima S, Oka A, Tsujimura A, Miyazaki M, Tsujimura K, Miyamura K, Ogawa S, Inoko H, Morishima Y, Kodera Y, Kuzushima K, Takahashi T: Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen. Blood. 2007 Aug 1;110(3):1055-63. Epub 2007 Apr 4.


Here we report the identification of a novel human leukocyte antigen (HLA)-B44-restricted minor histocompatibility antigen (mHA) with expression limited to hematopoietic cells. cDNA expression cloning studies demonstrated that the cytotoxic T lymphocyte (CTL) epitope of interest was encoded by a novel allelic splice variant of HMSD, hereafter designated as HMSD-v.
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18194362 Altermann WW, Grondkowski V, Reichert S, Seliger B, Schlaf G: A novel HLA-B*57 (B*5714) allele in a healthy male Caucasian individual. Tissue Antigens. 2008 Mar;71(3):253-4. Epub 2008 Jan 8.

A novel human leucocyte antigen (HLA)-B57 (HLA-B*5714) allele has been identified in a male Caucasian individual from Middle Europe using single allele-specific sequencing strategy.
This allele is identical to the HLA-B*570101 allele except for two point mutations in exon 3 at codon 138 (ACG--> ACC) with no amino acid change [persisting threonine (T)] and at codon 171 (TAC--> CAC), resulting in an amino acid change from tyrosine (Y) to histidine (H).
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19140835 Han SH, Jung SM, Park SR, Chung SY, Han H: Identification of a new HLA-A*11 allele, HLA-A*1135, by sequence-based typing in Korean individual. Tissue Antigens. 2009 Jan;73(1):62-3.

A novel human leukocyte antigen (HLA)-A allele has been identified in the cord blood of a Korean baby.
New HLA-A*1135 allele was different from HLA-A*1131 by three nucleotide substitution at codon 142 (ATC--> ACC) and codon 163 (CGG--> ACG), resulting in two amino acid change, Ile 142 Thr and Arg 163 Thr.
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18346033 Yan LN, Li SY, Dong Z, Dong L, Xie JH, Yuan YH, An SP: Identification of a novel HLA-B*54 allele, B*5411, by sequence-based typing in a Chinese individual. Tissue Antigens. 2008 May;71(5):484-5. Epub 2008 Mar 11.

We report here a novel human leukocyte antigen (HLA)-B*5411 allele identified by sequence-based typing in a Chinese individual.
The novel B*5411 is identical to B*5404, with the exception of four base substitutions at position 120 (A> C), 134 (G> C), 143 (C> G), and 156 (A> T) of exon 3 resulting in codon no. 131, changed from AGC (Ser) to CGC (Arg), and codon no. 143, changed from ACC (Thr) to TCC (Ser).
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17767559 Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL: HLA-A*020115 and HLA-Cw*030203 show new synonymous mutations in exon 4. Tissue Antigens. 2007 Oct;70(4):340-1.

Two novel human leukocyte antigen (HLA) class I alleles, A*020115 and Cw*030203, were completely characterized by sequencing-based typing.
In contrast, Cw*030203 differs from Cw*030202 in a point mutation at codon 271 (ACC > ACT).
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