Protein Information

Name protein kinase B
Synonyms AKT; PKB; Protein kinase B; AKT 1; AKT1; C AKT; Oncogene AKT1; PKB alpha…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19158325 Berggreen C, Gormand A, Omar B, Degerman E, Goransson O: Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E635-46. Epub 2009 Jan 21.

2(0,0,0,2) Details
18469022 Stoppa GR, Cesquini M, Roman EA, Prada PO, Torsoni AS, Romanatto T, Saad MJ, Velloso LA, Torsoni MA: Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. J Endocrinol. 2008 Jul;198(1):157-68. Epub 2008 May 9.


Concordantly, insulin receptor (IR), IR substrate type 1 (IRS1), IRS2, and protein kinase B (AKT) phosphorylation in adipose tissue and skeletal muscle was improved by citrate ICV treatment.
1(0,0,0,1) Details
20023137 Zhao JX, Yan X, Tong JF, Means WJ, McCormick RJ, Zhu MJ, Du M: Mouse AMP-activated protein kinase gamma3 subunit R225Q mutation affecting mouse growth performance when fed a high-energy diet. J Anim Sci. 2010 Apr;88(4):1332-40. Epub 2009 Dec 18.


High fat diet downregulates protein kinase B but upregulates extracellular signal-regulated kinase signaling.
1(0,0,0,1) Details
19268361 Zhu MJ, Du M, Nijland MJ, Nathanielsz PW, Hess BW, Moss GE, Ford SP: Down-regulation of growth signaling pathways linked to a reduced cotyledonary vascularity in placentomes of over-nourished, obese pregnant ewes. Placenta. 2009 May;30(5):405-10. Epub 2009 Mar 6.


Both protein kinase B (Akt) and extracellular signal-regulated kinase 1/2 (ERK1/2) are down-stream components of the insulin/insulin like growth factor-1 (IGF-1) signaling pathway.
1(0,0,0,1) Details