Protein Information

Name glucose transporter 4
Synonyms GLUT 4; GLUT4; Glucose transporter 4; SLC2A4; Solute carrier family 2 member 4; Glucose transporter 4s; Solute carrier family 2 member 4s

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
17884446 Guo Z, Xia Z, Yuen VG, McNeill JH: Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Metabolism. 2007 Oct;56(10):1363-71.


Adenosine monophosphate-activated protein kinase increases glucose transport by stimulating the translocation of glucose transporter 4 (GLUT4) to the sarcolemma in the heart.
5(0,0,0,5) Details
18790741 Stuck BJ, Lenski M, Bohm M, Laufs U: Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase. J Biol Chem. 2008 Nov 21;283(47):32562-9. Epub 2008 Sep 12.


This was paralleled by membrane translocation of glucose-transporter type 4 (GLUT4), increased uptake of [(3) H] glucose and transient down-regulation of phosphorylation of acetyl-CoA carboxylase (ACC), whereas fatty acid uptake remained unchanged.
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17934342 Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L: Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha. Exp Mol Med. 2007 Aug 31;39(4):535-43.


Glucose transporter 4 expression also decreased in old rats.
1(0,0,0,1) Details