| Name | biotin carboxylase |
|---|---|
| Synonyms | 3 Methylcrotonyl CoA carboxylase 2; Biotin carboxylase; 3 Methylcrotonyl CoA carboxylase non biotin containing subunit; 3 Methylcrotonyl Coenzyme A carboxylase 2; 3 Methylcrotonyl Coenzyme A carboxylase non biotin containing subunit; MCCB; MCCC 2; MCCC2… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17642515 | Kondo S, Nakajima Y, Sugio S, Sueda S, Islam MN, Kondo H: Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans. Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):885-90. Epub 2007 Jul 17. |
2(0,0,0,2) | Details |
| 18221116 | Corbett JW, Harwood JH Jr: Inhibitors of mammalian carboxylase. Recent Pat Cardiovasc Drug Discov. 2007 Nov;2(3):162-80. Co-crystallization of the biotin carboxylase and carboxyltransferase domains of eukaryotic ACC in the presence of substrates and inhibitors has revealed characteristics of the catalytic center that can be exploited in drug discovery. |
1(0,0,0,1) | Details |
| 18247344 | Lee CK, Cheong HK, Ryu KS, Lee JI, Lee W, Jeon YH, Cheong C: Biotinoyl domain of human carboxylase: Structural insights into the carboxyl transfer mechanism. Proteins. 2008 Aug;72(2):613-24. In ACC, the biotinoyl domain performs a critical function by transferring an activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, followed by carboxyl transfer to |
1(0,0,0,1) | Details |
| 19900410 | Cho YS, Lee JI, Shin D, Kim HT, Jung HY, Lee TG, Kang LW, Ahn YJ, Cho HS, Heo YS: Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem Biophys Res Commun. 2010 Jan 1;391(1):187-92. Epub 2009 Nov 10. Here, we report the crystal structures of the biotin carboxylase (BC) domain of human ACC2 phosphorylated by AMP-activated protein kinase (AMPK). |
1(0,0,0,1) | Details |
| 19263251 | Ruenwai R, Cheevadhanarak S, Laoteng K: Overexpression of carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha. Mol Biotechnol. 2009 Jul;42(3):327-32. Epub 2009 Mar 5. According to the amino acid sequence homology and the conserved structural organization of the biotin carboxylase, carboxyl carrier protein, and carboxyl transferase domains, the cloned gene was characterized as a multi-domain ACC1 protein. |
1(0,0,0,1) | Details |
| 19236960 | Kaushik VK, Kavana M, Volz JM, Weldon SC, Hanrahan S, Xu J, Caplan SL, Hubbard BK: Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics. Biochim Biophys Acta. 2009 Jun;1794(6):961-7. Epub 2009 Feb 21. Product inhibition studies support the notion that the enzyme proceeds through a hybrid (two-site) random Ter Ter mechanism, one that likely involves a two-step reaction at the biotin carboxylase domain. |
1(0,0,0,1) | Details |
| 19359168 | Raymer B, Kavana M, Price A, Wang B, Corcoran L, Kulathila R, Groarke J, Mann T: Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to carboxylase. Bioorg Med Chem Lett. 2009 May 15;19(10):2804-7. Epub 2009 Mar 26. The fluorescent label of the BODIPY can be used to biophysically identify a compound that binds to the Soraphen A site of the biotin carboxylase domain versus the carboxytransferase domain of ACC. |
32(0,1,1,2) | Details |