Protein Information

Name citrate lyase (protein family or complex)
Synonyms Citrate lyase; Citrate lyases

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
19427916 Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8.


The mRNA levels of malic enzyme (ME), ATP-citrate lyase (ACL), acetyl-CoA carboxylase alpha (ACCalpha), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1) and thyroid hormone responsive Spot 14 (Spot 14) declined in response to fasting.
1(0,0,0,1) Details
17762189 Mailloux R, Lemire J, Appanna V: Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity. Cell Physiol Biochem. 2007;20(5):627-38.


Electrophoretic and immunoblot analyses pointed to increased activities and expression of lipogenic enzymes such as glycerol 3-phosphate dehydrogenase (G3PDH), acetyl CoA carboxylase (ACC) and ATP-citrate lyase (CL) in the hepatocytes exposed to Al, and a sharp diminution of enzymes mediating oxidative phosphorylation.
1(0,0,0,1) Details
17984485 Jakus PB, Sandor A, Janaky T, Farkas V: Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation. J Lipid Res. 2008 Feb;49(2):332-9. Epub 2007 Nov 5.


Of the many proteins involved in the metabolic response, two lipogenic enzymes, acetyl-coenzyme A carboxylase (ACC) and ATP-citrate lyase, were found to play a pervasive role and studied in detail.
1(0,0,0,1) Details
17391151 Clapham JC, Arch JR: Thermogenic and metabolic antiobesity drugs: rationale and opportunities. Diabetes Obes Metab. 2007 May;9(3):259-75.


ATP citrate lyase, fatty acid synthase, acetyl-CoA carboxylase (ACC)], fatty acid interconversion [stearoyl-CoA desaturase (SCD)] and triglyceride synthesis (e.g. acyl-CoA : diacylglycerol acyltransferase) may all be thermogenic.
1(0,0,0,1) Details