| Name | fatty acid synthase |
|---|---|
| Synonyms | FAS; FAS; FASN; FASN protein; Fatty acid synthase; OA 519; FASN proteins; Fatty acid synthases… |
| Name | ACC |
|---|---|
| CAS | 1-aminocyclopropanecarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19156225 | Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, Ohta M, Kato N, Sasazuki T, Shirasawa S: Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. PLoS One. 2009;4(1):e4240. Epub 2009 Jan 21. Of interest is the down-regulation of fatty acid metabolism-related molecules, including acetyl-CoA carboxylase (ACC)-1, ACC-2 and fatty acid synthase in the liver of KRAP (-/-) mice, which could in part account for the metabolic phenotype in KRAP (-/-) mice. |
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| 19418221 | Saito M, Chakraborty G, Mao RF, Vadasz C, Saito M: Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain. Neurochem Res. 2009 Nov;34(11):1945-54. Epub 2009 May 6. It has been shown that lipogenic enzymes, such as fatty acid synthase (FAS) and carboxylase (ACC), are highly expressed in the rodent brain during the early neonatal period and decline thereafter. |
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| 19500808 | Chen CH, Chang MY, Lin YS, Lin DG, Chen SW, Chao PM: A herbal extract with carboxylase inhibitory activity and its potential for treating metabolic syndrome. Metabolism. 2009 Sep;58(9):1297-305. Epub 2009 Jun 18. In addition, EP at concentrations of 0.0725 and 0.145 mg/mL (2.5- and 5-fold higher than the half-maximal inhibitory concentration) was also effective in decreasing ACC and fatty acid synthase activity and the triacylglycerol content of HepG2 cells incubated in high- (30 mmol/L) medium. |
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| 17725831 | Salas A, Noe V, Ciudad CJ, Romero MM, Remesar X, Esteve M: Short-term oleoyl- treatment affects capacity to manage lipids in rat adipose tissue. BMC Genomics. 2007 Aug 28;8:292. The use of real-time PCR validate that, in mesenteric white adipose tissue, mRNA levels for Lipoprotein Lipase (LPL) were decreased by 52%, those of Fatty Acid Synthase (FAS) by 95%, those of Hormone Sensible Lipase (HSL) by 32%, those of Carboxylase (ACC) by 92%, those of Carnitine Palmitoyltransferase 1b (CPT1b) by 45%, and those of Fatty Acid Transport Protein 1 (FATP1) and Adipocyte Fatty Acid Binding Protein (FABP4) by 52% and 49%, respectively. |
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| 20036965 | Wang C, Rajput S, Watabe K, Liao DF, Cao D: carboxylase-a as a novel target for cancer therapy. Front Biosci (Schol Ed). 2010 Jan 1;2:515-26. is a critical bi-functional molecule, i.e., a substrate of fatty acid synthase (FAS) for acyl chain elongation (fatty acid synthesis) and an inhibitor of carnitine palmitoyltransferase I (CPT-I) for fatty acid beta-oxidation. |
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| 20041784 | Cho K, Kim SJ, Park SH, Kim S, Park T: Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food. 2009 Dec;12(6):1293-301. Chronic alcohol consumption up-regulated the hepatic expression of genes involved in inflammation, fatty acid synthesis, and metabolism, including tumor necrosis factor alpha (TNFalpha), liver X receptor alpha (LXRalpha), sterol regulatory element-binding protein (SREBP)-1c, fatty acid synthase, acetyl-coenzyme A carboxylase alpha (ACC), stearoyl-coenzyme A desaturase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), and low-density lipoprotein receptor (LDLR). |
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| 19036562 | Chen Q, Reimer RA: Dairy protein and alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition. 2009 Mar;25(3):340-9. Epub 2008 Nov 26. and whey downregulated the expression of intestinal-type fatty acid binding protein (i-FABP), fatty acid transport protein 4 (FATP4), Niemann-Pick C-1-like-1 protein (NPC1L1), carboxylase (ACC), fatty acid synthase (FAS), sterol regulatory element-binding protein-2 (SREBP-2), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR; P < 0.05). |
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| 18314006 | Pang J, Choi Y, Park T: Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch Biochem Biophys. 2008 Aug 15;476(2):178-85. Epub 2008 Feb 26. Feeding I. paraguariensis extract reversed the HFD-induced downregulation of the epididymal adipose tissue genes implicated in adipogenesis or thermogenesis, such as peroxisome proliferators' activated receptor gamma2, adipocyte fatty acid binding protein, sterol-regulatory-element-binding protein-1c, fatty acid synthase, HMG- reductase, uncoupling protein 2, and uncoupling protein 3. |
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| 19932008 | Kim EJ, Jin XJ, Kim YK, Oh IK, Kim JE, Park CH, Chung JH: UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging. J Dermatol Sci. 2010 Jan;57(1):19-26. Epub 2009 Nov 20. The expressions of genes related to lipid synthesis, including carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), sterol regulatory element binding proteins (SREBPs), and peroxisome proliferator-activated receptors (PPARgamma) were also markedly decreased. |
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| 17671740 | Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada M, Yada R, Harada N, Takayanagi R, Nakamuta M: Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 2007 Sep;20(3):351-8. The target genes for real-time PCR analysis were as follows: acetyl-CoA carboxylase (ACC) 1, ACC2, fatty acid synthase (FAS), sterol regulatory element-binding protein 1c (SREBP-1c), and adipose differentiation-related protein (ADRP) for evaluation of de novo synthesis and uptake of fatty acids; carnitine palmitoyltransferase 1a; (CPT1a), long-chain acyl-CoA dehydrogenase (LCAD), long-chain L-3-hydroxyacylcoenzyme A dehydrogenase alpha (HADHalpha), uncoupling protein 2 (UCP2), straight-chain acyl-CoA oxidase (ACOX), branched-chain acyl-CoA oxidase (BOX), cytochrome P450 2E1 (CYP2E1), CYP4A11, and peroxisome proliferator-activated receptor (PPAR) alpha for oxidation in the mitochondria, peroxisomes and microsomes; superoxide dismutase (SOD), catalase, and glutathione synthetase (GSS) for antioxidant pathways; and diacylglycerol O-acyltransferase 1 (DGAT1), PPARgamma, and hormone-sensitive lipase (HSL) for triglyceride synthesis and catalysis. |
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| 18082128 | MacDonald MJ, Dobrzyn A, Ntambi J, Stoker SW: The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells. Arch Biochem Biophys. 2008 Feb 15;470(2):153-62. Epub 2007 Dec 3. Inhibitors of ACC and fatty acid synthase inhibited insulin release in islets and INS-1 cells. |
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| 19878707 | Cho KH, Kim HJ, Kamanna VS, Vaziri ND: improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28. RESULTS: CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl- carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG- reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A. |
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| 19459711 | Way TD, Lin HY, Kuo DH, Tsai SJ, Shieh JC, Wu JC, Lee MR, Lin JK: Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells. J Agric Food Chem. 2009 Jun 24;57(12):5257-64. PR-3-5s decreased the expression of fatty acid synthase (FASN) and inhibited the activity of carboxylase (ACC) by stimulating AMP-activated protein kinase (AMPK) through the LKB1 pathway. |
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| 17577393 | Esfandiari F, You M, Villanueva JA, Wong DH, French SW, Halsted CH: attenuates hepatic lipid synthesis in micropigs fed with a -deficient diet. Alcohol Clin Exp Res. 2007 Jul;31(7):1231-9. feeding activated and SAM supplementation maintained control levels of ER stress-induced transcription factor sterol regulatory element-binding protein-1c (SREBP-1c) and its targeted transcripts of lipid synthesizing enzymes carboxylase (ACC), fatty acid synthase (FAS), and acyltransferase (GPAT). |
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| 20139613 | Yuan HD, Yuan HY, Chung SH, Jin GZ, Piao GC: An active part of Artemisia sacrorum Ledeb. attenuates hepatic lipid accumulation through activating AMP-activated protein kinase in human HepG2 cells. Biosci Biotechnol Biochem. 2010 Feb 23;74(2):322-8. Epub 2010 Feb 7. EE down-regulated the lipogenesis gene expression of sterol regulatory element-binding protein 1c (SREBP1c) and its target genes, such as fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1), in a time- and dose-dependent manner. |
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| 18617560 | Rector RS, Thyfault JP, Laye MJ, Morris RT, Borengasser SJ, Uptergrove GM, Chakravarthy MV, Booth FW, Ibdah JA: Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. J Physiol. 2008 Sep 1;586(Pt 17):4241-9. Epub 2008 Jul 10. In addition, cessation of daily exercise quickly increased the hepatic protein contents of fatty acid synthase and carboxylase (ACC), reduced ACC phosphorylation status, and dramatically increased hepatic concentration. |
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| 20019905 | Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, Aubert ML, Huppi PS: Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect. 2009 Oct;117(10):1549-55. Epub 2009 Jun 29. This excess of pWAT was associated with adipocyte hypertrophy and overexpression of lipogenic genes such as C/EBP-alpha (CAAT enhancer binding protein alpha), PPAR-gamma (peroxisome proliferator-activated receptor gamma), SREBP-1C (sterol regulatory element binding protein-1C), LPL (lipoprotein lipase), FAS (fatty acid synthase), and SCD-1 (stearoyl-CoA desaturase 1). |
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| 17391151 | Clapham JC, Arch JR: Thermogenic and metabolic antiobesity drugs: rationale and opportunities. Diabetes Obes Metab. 2007 May;9(3):259-75. ATP citrate lyase, fatty acid synthase, carboxylase (ACC)], fatty acid interconversion [stearoyl-CoA desaturase (SCD)] and triglyceride synthesis (e.g. acyl-CoA : diacylglycerol acyltransferase) may all be thermogenic. |
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| 18482975 | Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008 Jul 18;283(29):20015-26. Epub 2008 May 14. Polyphenols substantially prevent the impairment in phosphorylation of AMPK and its downstream target, ACC carboxylase), elevation in expression of FAS (fatty acid synthase), and lipid accumulation in human HepG2 hepatocytes exposed to high |
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| 18452391 | Chung CC, Ohwaki K, Schneeweis JE, Stec E, Varnerin JP, Goudreau PN, Chang A, Cassaday J, Yang L, Yamakawa T, Kornienko O, Hodder P, Inglese J, Ferrer M, Strulovici B, Kusunoki J, Tota MR, Takagi T: A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of production. Assay Drug Dev Technol. 2008 Jun;6(3):361-74. Here we report the development and miniaturization of a cell-free enzyme assay for ultra-high-throughput screening (uHTS) for inhibitors of two potential drug targets for obesity and cancer: fatty acid synthase (FAS) and carboxylase (ACC) 2. |
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| 19890358 | Guo HX, Liu DH, Ma Y, Liu JF, Wang Y, Du ZY, Wang X, Shen JK, Peng HL: Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin. 2009 Nov;30(11):1505-12. Baicalin reduced hepatic lipid accumulation, enhanced the phosphorylation of AMPK and ACC and down-regulated genes involved in lipogenesis, including fatty acid synthase and its upstream regulator SREBP-1c. |
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| 20060923 | Chen J, Tang X, Zhang Y, Ma H, Zou S: Effects of maternal treatment of on serum lipid profile and hepatic lipid metabolism-related gene expression in embryonic chickens. Comp Biochem Physiol B Biochem Mol Biol. 2010 Apr;155(4):380-6. Epub 2010 Jan 10. However, blood TC, and hepatic fatty acid synthase (FAS) and methylglutaryl- reductase (HMGR) gene expression were significantly up-regulated in the 100mg /kg group during embryonic development and hatching. |
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| 19508303 | Gnoni GV, Paglialonga G, Siculella L: inhibits fatty acid and triacylglycerol synthesis in rat-liver cells. Eur J Clin Invest. 2009 Sep;39(9):761-8. Epub 2009 Jun 8. Enzyme activities of carboxylase (ACC) and fatty acid synthase (FAS) as well as diacylglycerol acyltransferase (DGAT) and reductase (HMG--R), pace-setting steps of de novo fatty acid, triacylglycerol (TAG) and synthesis respectively were assayed in digitonin-permeabilized hepatocytes. |
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| 19543203 | Ortega FJ, Mayas D, Moreno-Navarrete JM, Catalan V, Gomez-Ambrosi J, Esteve E, Rodriguez-Hermosa JI, Ruiz B, Ricart W, Peral B, Fruhbeck G, Tinahones FJ, Fernandez-Real JM: The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects. Obesity (Silver Spring). 2010 Jan;18(1):13-20. Epub 2009 Jun 18. In this cross-sectional study, we aimed to evaluate the mRNA expression of fatty acid synthase (FAS) and carboxilase (ACC) in omental and subcutaneous (SC) fat depots from subjects who varied widely in terms of body fat mass. FAS and ACC gene expression were evaluated by real time-PCR in 188 samples of visceral adipose tissue which were obtained during elective surgical procedures in 119 women and 69 men. |
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| 19727214 | Huo M, Zang HL, Zhang DJ, Wang B, Wu J, Zhang XY, Chen LH, Li J, Yang JC, Guan YF: [Role of increased activity of carbohydrate response element binding protein in excessive lipid accumulation in the liver of type 2 diabetic db/db mouse]. Beijing Da Xue Xue Bao. 2009 Jun 18;41(3):307-12. The expressions of ChREBP and its target genes including acetyl-coenzyme A carboxylase 1 (Acc-1), fatty acid synthase (Fas), acyltransferase (Gpat) were analyzed by Real-time PCR and Western blot. |
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| 19716432 | Howell G 3rd, Deng X, Yellaturu C, Park EA, Wilcox HG, Raghow R, Elam MB: N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha. Biochim Biophys Acta. 2009 Dec;1791(12):1190-6. Epub 2009 Aug 27. N-3 fatty acids also effectively prevented insulin induction of the downstream lipogenic enzyme targets fatty acid synthase (FAS) and acetyl carboxyl coenzyme acetyltransferase-1 (ACC-1), and reduced de novo lipogenesis. |
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| 20230058 | Chao PM, Kuo YH, Lin YS, Chen CH, Chen SW, Kuo YH: The Metabolic Benefits of Polygonum hypoleucum Ohwi in HepG2 Cells and Wistar Rats under Lipogenic Stress. J Agric Food Chem. 2010 Mar 15. On incubating high (30 mM)-stimulated HepG2 cells with EP (72.5 or 145 mug/mL), ACC and fatty acid synthase activity, triacylglycerol content, and microsomal triacylglycerol transfer protein mRNA levels were all significantly reduced (P < 0.05, vs vehicle). |
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| 17449569 | Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR: downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J Nutr. 2007 May;137(5):1127-31. Thus, we investigated the effect of on fatty acid synthase (FAS) expressions in HepG2 cells. |
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| 19182950 | Kim do Y, Yuan HD, Chung IK, Chung SH: Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells. J Agric Food Chem. 2009 Feb 25;57(4):1532-7. Genes for fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1), well-known target molecules of SREBP1c, were also suppressed. |
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| 19427916 | Proszkowiec-Weglarz M, Richards MP, Humphrey BD, Rosebrough RW, McMurtry JP: AMP-activated protein kinase and carbohydrate response element binding protein: a study of two potential regulatory factors in the hepatic lipogenic program of broiler chickens. Comp Biochem Physiol B Biochem Mol Biol. 2009 Sep;154(1):68-79. Epub 2009 May 8. The mRNA levels of malic enzyme (ME), ATP-citrate lyase (ACL), acetyl-CoA carboxylase alpha (ACCalpha), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1) and thyroid hormone responsive Spot 14 (Spot 14) declined in response to fasting. |
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| 20205889 | Zhao S, Wang J, Song X, Zhang X, Ge C, Gao S: Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue. Nutr Metab. 2010 Jan 21;7:6. HP significantly reduced gene expression of carboxylase (ACC), fatty acid synthase (FAS) and sterol regulatory element binding protein 1c (SREBP-1c) at 60 kg and 100 kg; however, the mRNA level and enzyme activity of FAS were increased at 30 kg. |
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| 17574488 | Zhao S, Ma H, Zou S, Chen W: Effects of in ovo administration of on lipid metabolism and hepatic lipogenetic genes expression in broiler chickens during embryonic development. Lipids. 2007 Aug;42(8):749-57. Epub 2007 Jun 16. The mRNA levels of carboxylase (ACC), fatty acid synthase (FAS), malic enzyme (ME), apolipoprotein B100 (apoB100) and sterol regulator element binding protein-1c (SREBP-1c) were determined using real time quantitative PCR. |
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| 18174272 | Rector RS, Thyfault JP, Morris RT, Laye MJ, Borengasser SJ, Booth FW, Ibdah JA: Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G619-26. Epub 2008 Jan 3. However, fatty acid synthase and carboxylase (ACC) content were significantly reduced (approximately 70 and approximately 35%, respectively), and ACC phosphorylation and cytochrome c content were significantly elevated (approximately 35 and approximately 30%, respectively) in the Ex animals. |
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| 19255584 | Carmona MC, Amigo M, Barcelo-Batllori S, Julia M, Esteban Y, Moreno S, Gomis R: Dual effects of tungstate on adipocyte biology: inhibition of adipogenesis and stimulation of cellular consumption. Int J Obes. 2009 May;33(5):534-40. Epub 2009 Mar 3. Expression of key genes for adipocyte function (aP2, ACC, fatty acid synthase (FAS) and lipoprotein lipase (LPL)) and differentiation (CCAAT enhancer-binding protein (C/EBP) alpha and peroxisome proliferator-activated receptor gamma (PPARgamma)) was reduced by tungstate, whereas C/EBPbeta isoform LIP expression level was increased. |
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| 19411549 | Han C, Wang J, Li L, Zhang Z, Wang L, Pan Z: The role of insulin and in goose primary hepatocyte triglyceride accumulation. J Exp Biol. 2009 May;212(Pt 10):1553-8. Compared with the control group, 100 and 150 nmol l (-1) insulin increased TG accumulation, acetyl-CoA carboxylase-alpha (ACCalpha) and fatty acid synthase (FAS) activity, and the mRNA levels of sterol regulatory element-binding protein-1 (SREBP-1), FAS and ACCalpha genes. |
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| 18975056 | Han C, Wang J, Li L, Wang L, Zhang Z: The role of LXR alpha in goose primary hepatocyte lipogenesis. Mol Cell Biochem. 2009 Feb;322(1-2):37-42. Epub 2008 Oct 31. Triglyceride (TG) accumulation, acetyl-CoA carboxylase alpha (ACC alpha) and fatty acid synthase (FAS) activities, and gene expression levels of LXR alpha, sterol regulatory element-binding proteins-1 (SREBP-1), FAS, ACC alpha and lipoprotein lipase (LPL) were measured in primary hepatocytes. |
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| 17855643 | Kume S, Uzu T, Araki S, Sugimoto T, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Kubota N, Terauchi Y, Kadowaki T, Haneda M, Kashiwagi A, Koya D: Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. J Am Soc Nephrol. 2007 Oct;18(10):2715-23. Epub 2007 Sep 12. Renal lipogenesis accelerated, determined by increased renal mRNA expression of the lipogenic enzymes fatty acid synthase and carboxylase (ACC) and by increased ACC activity. |
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| 18794597 | Morgan K, Uyuni A, Nandgiri G, Mao L, Castaneda L, Kathirvel E, French SW, Morgan TR: Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2008 Sep;20(9):843-54. Hepatic expression of sterol regulatory element-binding protein-1c, carbohydrate response element-binding protein, liver X receptor-alpha, carboxylase (ACC), and fatty acid synthase (FAS) decreased during fasting in SF and HF mice; however, FAS expression and protein content were higher in the liver of fasted HF mice than of fasted SF mice. |
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| 19260951 | Gnoni GV, Paglialonga G: inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes. Eur J Clin Invest. 2009 Mar;39(3):211-8. Enzyme activities of carboxylase (ACC) and fatty acid synthase (FAS) as well as reductase (HMG--R), pace-setting steps of de novo fatty acid and synthesis, respectively, were in situ measured in digitonin-permeabilized hepatocytes. |
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| 19851294 | Mayas MD, Ortega FJ, Gomez-Huelgas R, Roca N, Fernandez-Real JM, Tinahones FJ: Decrease in FASN expression in adipose tissue of hypertensive individuals. Am J Hypertens. 2009 Dec;22(12):1258-62. Epub 2009 Oct 22. |
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| 18199615 | Vavere AL, Kridel SJ, Wheeler FB, Lewis JS: 1-11C- as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. J Nucl Med. 2008 Feb;49(2):327-34. Epub 2008 Jan 16. |
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| 19383549 | Wang PH, Ko YH, Chin HJ, Hsu C, Ding ST, Chen CY: The effect of feed restriction on expression of hepatic lipogenic genes in broiler chickens and the function of SREBP1. Comp Biochem Physiol B Biochem Mol Biol. 2009 Aug;153(4):327-31. Epub 2009 Apr 19. Indeed, the mRNA concentrations for fatty acid synthase (FAS), malic enzyme, and stearoyl coenzyme A desaturase were almost undetectable after the 24 h fasting. |
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| 19231861 | Kim JH, Jeong WS, Kim IH, Kim HJ, Kim SH, Kang GH, Lee HG, Yoon HG, Ham HJ, Kim YJ: Effect of an oil byproduct from (CLA) purification on CLA accumulation and lipogenic gene expression in broilers. J Agric Food Chem. 2009 Mar 25;57(6):2397-404. CLA supplementation also induced lipogenesis in the livers of the broilers, and it significantly increased the relative mRNA levels of sterol regulatory element binding protein 1 (SREBP1), as well as its target genes: fatty acid synthase (FAS) and carboxylase (ACC) (p < 0.05). |
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| 17635921 | An Z, Wang H, Song P, Zhang M, Geng X, Zou MH: -induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress. J Biol Chem. 2007 Sep 14;282(37):26793-801. Epub 2007 Jul 16. |
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| 17409402 | Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, Ronnett GV, Townsend CA, Kuhajda FP: Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res. 2007 Apr 1;67(7):2964-71. |
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| 18706411 | Li LF, Lu YY, Xiong W, Liu JY, Chen Q: Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal in mice. Eur J Pharmacol. 2008 Oct 24;595(1-3):90-4. Epub 2008 Jul 31. |
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| 18760332 | Swierczynski J, Goyke E, Korczynska J, Jankowski Z: carboxylase and fatty acid synthase activities in human hypothalamus. Neurosci Lett. 2008 Oct 31;444(3):209-11. Epub 2008 Aug 22. |
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