Protein Information

Name Ki 67
Synonyms Antigen KI 67; Antigen identified by monoclonal antibody Ki 67; KIA; Ki 67; MKI67; Proliferation related Ki 67 antigen; Antigen identified by monoclonal antibody Ki 67s; Ki 67s…

Compound Information

Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference List

PubMed Abstract RScore(About this table)
18248354 Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM: Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours. J Oral Pathol Med. 2008 May;37(5):309-18. Epub 2008 Jan 30.

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18366613 Yang JY, Yang MQ, Luo Z, Ma Y, Li J, Deng Y, Huang X: A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions. BMC Genomics. 2008;9 Suppl 1:S23.


It follows from a comprehensive statistical analysis that a number of antigens such as hTERT, PCNA and Ki-67 can be considered as cancer markers, while another set of antigens such as P27KIP1 and FHIT are possible markers for normal tissue.
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18326020 Vekony H, Raaphorst FM, Otte AP, van Lohuizen M, Leemans CR, van der Waal I, Bloemena E: High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma. J Clin Pathol. 2008 Jun;61(6):744-9. Epub 2008 Mar 6.


METHODS: Expression of the cell cycle proteins p53, cyclin D1, p16 (INK4a), E2F1 and Ki-67, together with the Polycomb group (PcG) proteins BMI-1, MEL-18, EZH2 and EED was investigated immunohistochemically 21 formalin-fixed, paraffin-embedded primary ACCs in relation to tumour characteristics.
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18515402 Advani A, Vaikkakara S, Gill MS, Arun CS, Pearce SH, Ball SG, James RA, Lennard TW, Bliss RD, Quinton R, Johnson SJ: Impact of standardised reporting in adrenocortical carcinoma: a single centre clinicopathological review. J Clin Pathol. 2008 Aug;61(8):939-44. Epub 2008 May 30.


A systematic evaluation of Ki-67 immunolabelling was also performed.
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17974017 Vakkala M, Laurila JJ, Saarnio J, Koivukangas V, Syrjala H, Karttunen T, Soini Y, Ala-Kokko TI: Cellular turnover and expression of hypoxic-inducible factor in acute acalculous and calculous cholecystitis. Crit Care. 2007;11(5):R116.


The immunohistochemical stains included antibodies to Ki-67 (proliferation), M30 (apoptosis) and HIF-1alpha.
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18059225 Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E: Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007 Nov;31(11):1683-94.


Ki-67 and p53 labeling indices were elevated in the high-grade components, though c-kit and cyclin-D1 were not.
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19955217 Luconi M, Mangoni M, Gelmini S, Poli G, Nesi G, Francalanci M, Pratesi N, Cantini G, Lombardi A, Pepi M, Ercolino T, Serio M, Orlando C, Mannelli M: Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model. Endocr Relat Cancer. 2010 Feb 18;17(1):169-77. Print 2010 Mar.


Tumor immunohistochemistry showed that Ki-67 was reduced in RGZ versus control group.
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20016788 Malhotra KP, Agrawal V, Pandey R: High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study. Head Neck Pathol. 2009 Dec;3(4):310-314. Epub 2009 Jun 20.


Immunohistochemical study of the undifferentiated component as compared to conventional ACC showed greater over-expression of p53 and Ki-67.
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