Protein Information

Name caspase 3
Synonyms Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
20225657 Jeong YM, Oh MH, Kim SY, Li H, Yun HY, Baek KJ, Kwon NS, Kim WY, Kim DS: Indole-3-acetic acid/horseradish peroxidase induces apoptosis in TCCSUP human urinary bladder carcinoma cells. Pharmazie. 2010 Feb;65(2):122-6.


We further investigated the IAA/HRP-mediated apoptotic pathways and showed that IAA/HRP induces caspase-8 and caspase-9 activation, which results in caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details
17142972 Kim DS, Kim SY, Jeong YM, Jeon SE, Kim MK, Kwon SB, Na JI, Park KC: Light-activated indole-3-acetic acid induces apoptosis in g361 human melanoma cells. Biol Pharm Bull. 2006 Dec;29(12):2404-9.


We further investigated IAAUVB-mediated apoptotic pathways, and found that IAAUVB causes caspase-8, Bid, caspase-3 activation, and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details
12244574 Greco O, Dachs GU, Tozer GM, Kanthou C: Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy. J Cell Biochem. 2002;87(2):221-32.


In the present work, some of the molecular and morphological features of the cells treated with HRP/IAA gene therapy were analysed.
0(0,0,0,0) Details
11833936 Abdo MA, Richards A, Atiya N, Singh B, Parkinson S, Hisheh S, Dharmarajan AM: Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea. Reprod Fertil Dev. 2001;13(5-6):395-403.


The final component of the study was to examine caspase-3 protein expression.
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19721241 Park KC, Kim SY, Kim DS: Experimental photodynamic therapy for liver cancer cell-implanted nude mice by an indole-3-acetic acid and intense pulsed light combination. Biol Pharm Bull. 2009 Sep;32(9):1609-13.


Then, tissue was taken for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay and immunohistochemical staining for 8-hydroxy-deoxyguanosine (8-OHdG), p53, caspase-3, and proliferating cell nuclear antigen (PCNA).
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18164246 d'Anglemont de Tassigny A, Berdeaux A, Souktani R, Henry P, Ghaleh B: The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2. Eur J Heart Fail. 2008 Jan;10(1):39-46.


Doxorubicin induced increases in both annexin V labelling and caspase-3 activity and decreases in cell volume.
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14607278 Kim DS, Jeon SE, Park KC: Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal. 2004 Jan;16(1):81-8.


We further investigated the IAA/HRP-mediated apoptotic pathways, and found that IAA/HRP activates caspase-8 and caspase-9, leading to caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details
15855049 Dhar-Mascareno M, Carcamo JM, Golde DW: Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic Biol Med. 2005 May 15;38(10):1311-22.

Since vitamin C is a potent antioxidant and quenches ROS, we investigated the role of intracellular ascorbic acid (iAA) in endothelial cells undergoing hypoxia-reperfusion.
Intracellular AA also prevents loss of mitochondrial membrane potential and the release of cytochrome C and activation of caspase-9 and caspase-3 during H-R.
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16880616 Kim DS, Kim SY, Jeong YM, Jeon SE, Kim MK, Kwon SB, Park KC: Indole-3-acetic acid/horseradish peroxidase-induced apoptosis involves cell surface CD95 (Fas/APO-1) expression. Biol Pharm Bull. 2006 Aug;29(8):1625-9.


In addition, the IAA/HRP-induced activations of CD95 downstream molecules, i.e., caspase-8, Bid, and caspase-3, were also inhibited by catalase.
1(0,0,0,1) Details
15482374 d'Anglemont de Tassigny A, Souktani R, Henry P, Ghaleh B, Berdeaux A: Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. Fundam Clin Pharmacol. 2004 Oct;18(5):531-8.


AVD as well as increases in the early markers of apoptosis, annexin V labeling and caspase-3 activity.
1(0,0,0,1) Details
16460736 Kim DS, Jeon SE, Jeong YM, Kim SY, Kwon SB, Park KC: Hydrogen peroxide is a mediator of indole-3-acetic acid/horseradish peroxidase-induced apoptosis. FEBS Lett. 2006 Feb 20;580(5):1439-46. Epub 2006 Jan 31.


On further investigating the IAA/HRP-mediated apoptotic pathway, we found that the IAA/HRP reaction leads to caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage, which was also blocked by catalase.
1(0,0,0,1) Details