| Name | ubiquitin |
|---|---|
| Synonyms | HMG20; RPS27A; UBA80; UBCEP 1; UBCEP1; UBA52; UBCEP 2; UBCEP2… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19915560 | Nishimura K, Fukagawa T, Takisawa H, Kakimoto T, Kanemaki M: An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat Methods. 2009 Dec;6(12):917-22. Epub 2009 Nov 15. Plants have evolved a unique system in which the plant hormone auxin directly induces rapid degradation of the AUX/IAA family of transcription repressors by a specific form of the SCF E3 ubiquitin ligase. |
31(0,1,1,1) | Details |
| 18391211 | Hayashi K, Tan X, Zheng N, Hatate T, Kimura Y, Kepinski S, Nozaki H: Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5632-7. Epub 2008 Apr 7. TIR1 is the substrate receptor of the ubiquitin-ligase complex SCF (TIR1). |
4(0,0,0,4) | Details |
| 15208392 | Chuang HW, Zhang W, Gray WM: Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF (TIR1) ubiquitin ligase. Plant Cell. 2004 Jul;16(7):1883-97. Epub 2004 Jun 18. |
4(0,0,0,4) | Details |
| 12782725 | Gray WM, Muskett PR, Chuang HW, Parker JE: Arabidopsis SGT1b is required for SCF (TIR1)-mediated auxin response. Plant Cell. 2003 Jun;15(6):1310-9. This complex functions as a ubiquitin protein ligase that targets members of the auxin/ (Aux/IAA) family of transcriptional regulators for ubiquitin-mediated degradation in response to auxin. |
2(0,0,0,2) | Details |
| 19114460 | Gilkerson J, Hu J, Brown J, Jones A, Sun TP, Callis J: Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana. Genetics. 2009 Mar;181(3):945-63. Epub 2008 Dec 29. Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. |
2(0,0,0,2) | Details |
| 18631113 | Mockaitis K, Estelle M: Auxin receptors and plant development: a new signaling paradigm. Annu Rev Cell Dev Biol. 2008;24:55-80. Auxin binds to TIR1, the F-box subunit of the ubiquitin ligase complex SCF (TIR1), and stabilizes the interaction between TIR1 and Aux/IAA substrates. |
2(0,0,0,2) | Details |
| 17410169 | Tan X, Calderon-Villalobos LI, Sharon M, Zheng C, Robinson CV, Estelle M, Zheng N: Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature. 2007 Apr 5;446(7136):640-5. |
2(0,0,0,2) | Details |
| 17559514 | Yang P, Smalle J, Lee S, Yan N, Emborg TJ, Vierstra RD: Ubiquitin C-terminal hydrolases 1 and 2 affect shoot architecture in Arabidopsis. Plant J. 2007 Aug;51(3):441-57. Epub 2007 Jun 8. |
2(0,0,0,2) | Details |
| 15994909 | Tao LZ, Cheung AY, Nibau C, Wu HM: RAC GTPases in tobacco and Arabidopsis mediate auxin-induced formation of proteolytically active nuclear protein bodies that contain AUX/IAA proteins. Plant Cell. 2005 Aug;17(8):2369-83. Epub 2005 Jul 1. Auxin signaling relies on ubiquitin ligase SCF (TIR1)-mediated 26S proteasome-dependent proteolysis of a large family of short-lived transcription regulators, auxin/ (Aux/IAA), resulting in the derepression of auxin-responsive genes. |
2(0,0,0,2) | Details |
| 11713520 | Gray WM, Kepinski S, Rouse D, Leyser O, Estelle M: Auxin regulates SCF (TIR1)-dependent degradation of AUX/IAA proteins. Nature. 2001 Nov 15;414(6861):271-6. Previous studies have implicated the ubiquitin-ligase SCF (TIR1) and the AUX/IAA proteins in auxin response. |
1(0,0,0,1) | Details |
| 12887580 | Zenser N, Dreher KA, Edwards SR, Callis J: Acceleration of Aux/IAA proteolysis is specific for auxin and independent of AXR1. Plant J. 2003 Aug;35(3):285-94. To further examine auxin-mediated increases in proteolysis, the degradation of two other LUC fusion proteins, a non-cleavable ubiquitin LUC fusion (UB1-72::LUC) and SAUR15::LUC was determined in vivo in seedlings. |
1(0,0,0,1) | Details |
| 17579493 | Abel S: Auxin is surfacing. ACS Chem Biol. 2007 Jun 15;2(6):380-4. This work establishes a novel mechanism of E3 regulation by small molecules and promises a novel strategy for the treatment of human disorders associated with defective ubiquitin-dependent proteolysis. |
1(0,0,0,1) | Details |
| 18298415 | Sato A, Yamamoto KT: Overexpression of the non-canonical Aux/IAA genes causes auxin-related aberrant phenotypes in Arabidopsis. Physiol Plant. 2008 Jun;133(2):397-405. Epub 2008 Feb 21. Degradation of Aux/IAA proteins which are triggered by the ubiquitin ligase complex containing the auxin F-box receptors (AFBs), is thought to be the primary reaction of auxin signaling. |
1(0,0,0,1) | Details |
| 16920877 | Walsh TA, Neal R, Merlo AO, Honma M, Hicks GR, Wolff K, Matsumura W, Davies JP: Mutations in an auxin receptor homolog AFB5 and in SGT1b confer resistance to synthetic picolinate auxins and not to 2,4-dichlorophenoxyacetic acid or in Arabidopsis. Plant Physiol. 2006 Oct;142(2):542-52. Epub 2006 Aug 18. TIR1 is the recognition component of the Skp1-cullin-F-box complex associated with the ubiquitin-proteasome pathway involved in auxin signaling and has recently been shown to be a receptor for IAA and 2,4-D. |
1(0,0,0,1) | Details |
| 19171357 | Hayashi K, Kamio S, Oono Y, Townsend LB, Nozaki H: Toyocamycin specifically inhibits auxin signaling mediated by SCFTIR1 pathway. Phytochemistry. 2009 Jan;70(2):190-7. Epub 2009 Jan 24. Toyocamycin also blocked auxin-enhanced degradation of the Aux/IAA repressor modulated by the SCF (TIR1) ubiquitin-proteasome pathway without inhibiting proteolytic activity of proteasome. |
1(0,0,0,1) | Details |
| 12690101 | Hayashi K, Jones AM, Ogino K, Yamazoe A, Oono Y, Inoguchi M, Kondo H, Nozaki H: Yokonolide B, a novel inhibitor of auxin action, blocks degradation of AUX/IAA factors. J Biol Chem. 2003 Jun 27;278(26):23797-806. Epub 2003 Apr 9. Gain of function mutants such as shy2-2, slr1, and axr2-1 encoding AUX/IAA transcriptional repressors and loss of function mutants encoding components of the ubiquitin-proteolytic pathway such as axr1-3 and tir1-1, which display increased AUX/IAAs protein stability, are less sensitive to YkB, although axr1 and tir1 mutants were sensitive to MG132, a general proteasome inhibitor, consistent with a site of action downstream of AXR1 and TIR. |
1(0,0,0,1) | Details |
| 15295098 | Kepinski S, Leyser O: Auxin-induced SCFTIR1-Aux/IAA interaction involves stable modification of the SCFTIR1 complex. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12381-6. Epub 2004 Aug 4. Auxin-induced Aux/IAA degradation requires the protein-ubiquitin ligase SCF (TIR1), with auxin acting to enhance the interaction between the Aux/IAAs and SCF (TIR1). |
1(0,0,0,1) | Details |
| 19309453 | Maraschin Fdos S, Memelink J, Offringa R: Auxin-induced, SCF (TIR1)-mediated poly-ubiquitination marks AUX/IAA proteins for degradation. Plant J. 2009 Jul;59(1):100-9. Epub 2009 Feb 26. Auxin enhances the binding of Aux/IAA proteins to the receptor TIR1, which is an F-box protein that is part of the E3 ubiquitin ligase complex SCF (TIR1). |
1(0,0,0,1) | Details |
| 15917798 | Kepinski S, Leyser O: The Arabidopsis F-box protein TIR1 is an auxin receptor. . Nature. 2005 May 26;435(7041):446-51. Central to auxin response are changes in gene expression, brought about by auxin-induced interaction between the Aux/IAA transcriptional repressor proteins and the ubiquitin-ligase complex SCF (TIR1), thus targeting for them proteolysis. |
1(0,0,0,1) | Details |
| 12226665 | Xie Q, Guo HS, Dallman G, Fang S, Weissman AM, Chua NH: SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature. 2002 Sep 12;419(6903):167-70. |
1(0,0,0,1) | Details |
| 12036263 | Dharmasiri S, Estelle M: The role of regulated protein degradation in auxin response. Plant Mol Biol. 2002 Jun-Jul;49(3-4):401-9. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. |
1(0,0,0,1) | Details |
| 11709180 | Rogg LE, Bartel B: Auxin signaling: derepression through regulated proteolysis. Dev Cell. 2001 Nov;1(5):595-604. Aux/IAA proteins are unstable, and their degradation is triggered by a ubiquitin-protein ligase that is regulated by modification with a ubiquitin-related protein. |
1(0,0,0,1) | Details |
| 16478940 | Laskowski M: Teaching resources. Sci STKE. 2006 Feb 14;2006(322):tr1. TIR1 is an auxin receptor and also a subunit of an SCF-type ubiquitin ligase. |
1(0,0,0,1) | Details |
| 16317577 | Raghavan C, Ong EK, Dalling MJ, Stevenson TW: Regulation of genes associated with auxin, ethylene and ABA pathways by 2,4-dichlorophenoxyacetic acid in Arabidopsis. Funct Integr Genomics. 2006 Jan;6(1):60-70. Epub 2005 Nov 22. Results of this study indicated that 2,4-D induced the expression of auxin-response genes (IAA1, IAA13, IAA19) at both auxinic and herbicidal levels of application, whereas the TIR1 and ASK1 genes, which are associated with ubiquitin-mediated auxin signalling, were down-regulated in response to low concentrations of 2,4-D application. |
1(0,0,0,1) | Details |
| 12036262 | Liscum E, Reed JW: Genetics of Aux/IAA and ARF action in plant growth and development. Plant Mol Biol. 2002 Jun-Jul;49(3-4):387-400. Mutations have been identified in a wide variety of auxin-response components, including auxin transporters, protein kinases and phosphatases, components of a ubiquitin-proteosome pathway, and transcriptional regulators. |
1(0,0,0,1) | Details |
| 17692850 | Scherer GF, Zahn M, Callis J, Jones AM: A role for phospholipase A in auxin-regulated gene expression. FEBS Lett. 2007 Sep 4;581(22):4205-11. Epub 2007 Aug 3. Factors that bind to the auxin response elements of the DR5 promoter and thereby regulate gene expression are regulated by a set of proteins such as Aux/IAA1 whose abundances are, in part, under control of E3 ubiquitin ligase SCF complexes. |
1(0,0,0,1) | Details |