Protein Information

Name caspase 8
Synonyms Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP 4; CAP4; CASP 8; CASP8; CASP8 protein; Caspase 8…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
16880616 Kim DS, Kim SY, Jeong YM, Jeon SE, Kim MK, Kwon SB, Park KC: Indole-3-acetic acid/horseradish peroxidase-induced apoptosis involves cell surface CD95 (Fas/APO-1) expression. Biol Pharm Bull. 2006 Aug;29(8):1625-9.


In addition, the IAA/HRP-induced activations of CD95 downstream molecules, i.e., caspase-8, Bid, and caspase-3, were also inhibited by catalase.
2(0,0,0,2) Details
14607278 Kim DS, Jeon SE, Park KC: Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal. 2004 Jan;16(1):81-8.


We further investigated the IAA/HRP-mediated apoptotic pathways, and found that IAA/HRP activates caspase-8 and caspase-9, leading to caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details
17142972 Kim DS, Kim SY, Jeong YM, Jeon SE, Kim MK, Kwon SB, Na JI, Park KC: Light-activated indole-3-acetic acid induces apoptosis in g361 human melanoma cells. Biol Pharm Bull. 2006 Dec;29(12):2404-9.


We further investigated IAAUVB-mediated apoptotic pathways, and found that IAAUVB causes caspase-8, Bid, caspase-3 activation, and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details
20225657 Jeong YM, Oh MH, Kim SY, Li H, Yun HY, Baek KJ, Kwon NS, Kim WY, Kim DS: Indole-3-acetic acid/horseradish peroxidase induces apoptosis in TCCSUP human urinary bladder carcinoma cells. Pharmazie. 2010 Feb;65(2):122-6.


We further investigated the IAA/HRP-mediated apoptotic pathways and showed that IAA/HRP induces caspase-8 and caspase-9 activation, which results in caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details