Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
16598858 Larson SK, Dwyer D, Lo HH, Ghafourifar P: Mitochondrial cytochrome c reacts with nitric oxide via S-nitrosation. Biochem Biophys Res Commun. 2006 Apr 14;342(3):991-5.

7(0,0,0,7) Details
15292139 Lee S, Flores-Encarnacion M, Contreras-Zentella M, Garcia-Flores L, Escamilla JE, Kennedy C: Indole-3-acetic acid biosynthesis is deficient in Gluconacetobacter diazotrophicus strains with mutations in cytochrome c biogenesis genes. J Bacteriol. 2004 Aug;186(16):5384-91.

3(0,0,0,3) Details
10359640 Savitsky PA, Gazaryan IG, Tishkov VI, Lagrimini LM, Ruzgas T, Gorton L: Oxidation of indole-3-acetic acid by dioxygen catalysed by plant peroxidases: specificity for the enzyme structure. Biochem J. 1999 Jun 15;340 ( Pt 3):579-83.


Cytochrome c peroxidase (CcP), fungal peroxidases (manganese-dependent peroxidase, lignin peroxidase and Arthromyces ramosus peroxidase) and microperoxidase were essentially inactive towards IAA in the absence of added H2O2.
1(0,0,0,1) Details
15855049 Dhar-Mascareno M, Carcamo JM, Golde DW: Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic Biol Med. 2005 May 15;38(10):1311-22.

Since vitamin C is a potent antioxidant and quenches ROS, we investigated the role of intracellular ascorbic acid (iAA) in endothelial cells undergoing hypoxia-reperfusion.
Intracellular AA also prevents loss of mitochondrial membrane potential and the release of cytochrome C and activation of caspase-9 and caspase-3 during H-R.
1(0,0,0,1) Details