Protein Information

Name interleukin (protein family or complex)
Synonyms Interleukin; Interleukins; interleukin receptor; interleukin receptors

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
11317661 Nicoletti F, Conget I, Di Marco R, Speciale AM, Morinigo R, Bendtzen K, Gomis R: Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes. Diabetologia. 2001 Mar;44(3):309-11.


AIMS/HYPOTHESIS: Interleukin (IL)-18 is a cytokine primarily produced by macrophages and capable of inducing T lymphocyte synthesis of interferon (IFN)-gamma.
2(0,0,0,2) Details
19701549 Garcia D D, Oyarzun A A, Angel B B, Carrasco P E, Perez B F: [Association of GHRd3 variant of growth hormone receptor gene with autoimmunity in type 1 diabetes]. Rev Med Chil. 2009 May;137(5):609-16. Epub 2009 Jul 17.


Among type 1 diabetic children, the carriers of the GHRd3 polymorphism had significantly higher levels of interleukin-lB than homozygous for the wild type genotype (5.7 and 17.7, pg/ml respectively p <0.015).
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16686259 Tso TK, Huang WN, Huang HY, Chang CK: Elevation of plasma interleukin-18 concentration is associated with insulin levels in patients with systemic lupus erythematosus. Lupus. 2006;15(4):207-12.


Recent studies demonstrated that interleukin (IL)-18, a novel pro-inflammatory cytokine, may be involved in triggering the inflammatory processes in SLE and the concentrations of circulating IL-18 in SLE patients were significantly higher than those in healthy subjects.
1(0,0,0,1) Details