| Name | DR3 |
|---|---|
| Synonyms | APO 3; TR3; APO3; Apo 3; Apoptosis inducing receptor; Apoptosis inducing receptor AIR; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9878086 | Yamamoto AM, Deschamps I, Garchon HJ, Roussely H, Moreau N, Beaurain G, Robert JJ, Bach JF: Young age and HLA markers enhance the risk of progression to type 1 diabetes in antibody-positive siblings of diabetic children. J Autoimmun. 1998 Dec;11(6):643-50. HLA-DR3/4 was significantly more frequent in siblings developing type 1 diabetes than in non-diabetic siblings (9/12 vs. 39/217, relative risk (RR)=14, P |
3(0,0,0,3) | Details |
| 20140847 | Kordonouri O, Hartmann R, Charpentier N, Knip M, Danne T, Ilonen J: Genetic Risk Markers Related to Diabetes-Associated Autoantibodies in Young Patients with Type 1 Diabetes in Berlin, Germany. Exp Clin Endocrinol Diabetes. 2010 Feb 5. METHODS: Blood samples from 243 paediatric patients were genotyped for the high-risk HLA haplotypes DR3-DQ2 (DQA1*05-DQB1*02) and DR4-DQ8 (DRB1*0401/2/4/5-DQB1*0302) and PTPN22 C1858 T polymorphism. |
2(0,0,0,2) | Details |
| 12557109 | Schilling I, Conrad K, Fussel M, Henker J: [Prevalence of type 1 diabetes-specific autoantibodies and of certain HLA patterns in celiac disease]. Dtsch Med Wochenschr. 2003 Jan 31;128(5):185-9. HLA-DR3, that occurs in both CD and diabetes, was demonstrated in 78% of the patients with CD. |
2(0,0,0,2) | Details |
| 9562346 | Savola K, Bonifacio E, Sabbah E, Kulmala P, Vahasalo P, Karjalainen J, Tuomilehto-Wolf E, Merilainen J, Akerblom HK, Knip M: IA-2 antibodies--a sensitive marker of IDDM with clinical onset in childhood and adolescence. Diabetologia. 1998 Apr;41(4):424-9. The prevalence and level of IA-2A were increased in cases carrying HLA DR4/non-DR3 compared with other DR combinations. |
2(0,0,0,2) | Details |
| 12116176 | Knip M, Kukko M, Kulmala P, Veijola R, Simell O, Akerblom HK, Ilonen J: Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. Am J Med Genet. 2002 May 30;115(1):48-54. In contrast, those with the DR3-DQB1*02 haplotype had increased GADA titers but low IAA and IA-2 levels. |
1(0,0,0,1) | Details |
| 12930364 | Viskari H, Paronen J, Keskinen P, Simell S, Zawilinska B, Zgorniak-Nowosielska I, Korhonen S, Ilonen J, Simell O, Haapala AM, Knip M, Hyoty H: Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome. Clin Exp Immunol. 2003 Sep;133(3):378-83. Eight patients carried the HLA-DR3-associated HLA-DQB1*02-DQA1*05 haplotype. |
1(0,0,0,1) | Details |
| 11679444 | Savola K, Laara E, Vahasalo P, Kulmala P, Akerblom HK, Knip M: Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study. Diabetes. 2001 Nov;50(11):2625-32. Positive seroconversions seemed to be associated with a young age of the sibling, HLA DR3/DR4 heterozygosity, HLA identity, and a high initial number of detectable autoantibodies. |
1(0,0,0,1) | Details |
| 12114788 | Kloppel G, Clemens A: Insulin-Dependent Diabetes Mellitus: Islet Changes in Relation to Etiology and Pathogenesis. Endocr Pathol. 1997 Winter;8(4):273-282. An important factor appears to be a genetic predisposition (human leukocyte antigen [HLA] DR3/DR4/DQ8) in connection with as-yet-unknown environmental factors (e.g., viruses). |
1(0,0,0,1) | Details |
| 18176860 | Taplin CE, Barker JM: Autoantibodies in type 1 diabetes. Autoimmunity. 2008 Feb;41(1):11-8. The highest risk HLA-DR3/4 DQ8 genotype has been shown to be highly associated with beta-cell autoimmunity. |
1(0,0,0,1) | Details |
| 16442659 | Holmberg H, Vaarala O, Sadauskaite-Kuehne V, Ilonen J, Padaiga Z, Ludvigsson J: Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes. Diabetes Res Clin Pract. 2006 Jun;72(3):308-14. Epub 2006 Jan 26. The frequency of the risk haplotype DR4-DQ8 was higher in Swedish than in Lithuanian patients (p = 0.004), as well as the high-risk combination of DR4-DQ8 and DR3-DQ2 haplotypes (p = 0.009). |
1(0,0,0,1) | Details |
| 12445130 | Jones B, Frasse P, Olmos E, Zegzouti H, Li ZG, Latche A, Pech JC, Bouzayen M: Down-regulation of DR12, an auxin-response-factor homolog, in the tomato results in a pleiotropic phenotype including dark green and blotchy ripening fruit. Plant J. 2002 Nov;32(4):603-13. Based on sequence homology, DR1, DR3, DR4 and DR8 are members of the Aux/IAA family, and DR12 belongs to the auxin response factor (ARF) family of transcription factors. |
1(0,0,0,1) | Details |
| 10753042 | Colman PG, Steele C, Couper JJ, Beresford SJ, Powell T, Kewming K, Pollard A, Gellert S, Tait B, Honeyman M, Harrison LC: Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia. 2000 Feb;43(2):203-9. Of the latter, 10 (2.8% overall) were persistently positive; they had higher frequencies of HLA DR4 (p < 0.01) and HLA DR3, 4 (p < 0.05). |
1(0,0,0,1) | Details |
| 10229311 | Rodriguez-Villar C, Conget I, Casamitjana R, Ercilla G, Gomis R: Effects of insulin administration in a group of high-risk, non-diabetic, first-degree relatives of Type 1 diabetic patients: an open pilot trial. Diabet Med. 1999 Feb;16(2):160-3. All subjects who developed diabetes were positive for antibodies to GAD and expressed the HLA-DR3 or DR4 alleles, whereas only one of the non-progressors had these parameters (P < 0.05). |
1(0,0,0,1) | Details |
| 18588707 | Murgia C, Orru M, Portoghese E, Garau N, Zedda P, Berria R, Motzo C, Sulis S, Murenu M, Paoletti AM, Melis GB: Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Reprod Biol Endocrinol. 2008 Jun 29;6:24. Sardinia has an unusual distribution of haplotypes and genotypes, with the highest population frequency of HLA DR3 in the world, and after Finland, the highest prevalence of Type 1 diabetes and Autoimmune-related Diseases. |
1(0,0,0,1) | Details |
| 10714434 | Kretowski A, Maciej K, Ida K: The analysis of in vitro transforming growth factor-beta1 (TGF-beta1) production by peripheral blood in overt and pre-clinical type 1 diabetes mellitus. Immunol Lett. 2000 Feb 1;71(2):85-9. In the first degree relatives HLA typing (for DR3, DR4 and DQB1*0602 alleles), measurements of anti-pancreatic antibodies (ICA, GADA, IA-2A, IAA) and intravenous tolerance tests were performed. |
1(0,0,0,1) | Details |