Protein Information

Name ARF5
Synonyms ADP ribosylation factor 5; ARF 5; ARF5

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
20133796 De Smet I, Lau S, Voss U, Vanneste S, Benjamins R, Rademacher EH, Schlereth A, De Rybel B, Vassileva V, Grunewald W, Naudts M, Levesque MP, Ehrismann JS, Inze D, Luschnig C, Benfey PN, Weijers D, Van Montagu MC, Bennett MJ, Jurgens G, Beeckman T: Bimodular auxin response controls organogenesis in Arabidopsis. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2705-10. Epub 2010 Jan 25.


We were able to demonstrate the complementary and sequential action of two discrete auxin response modules, the previously described Solitary Root/indole-3-Acetic Acid (IAA) 14-Auxin Response Factor (ARF) 7-ARF19-dependent lateral root initiation module and the successive Bodenlos/IAA12-Monopteros/ARF5-dependent module, both of which are required for proper organogenesis.
1(0,0,0,1) Details
12101120 Hamann T, Benkova E, Baurle I, Kientz M, Jurgens G: The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes Dev. 2002 Jul 1;16(13):1610-5.


Developmental responses to the plant hormone auxin are thought to be mediated by interacting pairs from two protein families: short-lived inhibitory IAA proteins and ARF transcription factors binding to auxin-response elements. monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate the root meristem during early embryogenesis.
0(0,0,0,0) Details
15889151 Weijers D, Benkova E, Jager KE, Schlereth A, Hamann T, Kientz M, Wilmoth JC, Reed JW, Jurgens G: Developmental specificity of auxin response by pairs of ARF and Aux/IAA transcriptional regulators. EMBO J. 2005 May 18;24(10):1874-85. Epub 2005 May 5.


Here we show that stabilization of BDL/IAA12 or its sister protein IAA13 prevents MP/ARF5-dependent embryonic root formation whereas stabilized SHY2/IAA3 interferes with seedling growth.
2(0,0,0,2) Details
16854942 Muto H, Nagao I, Demura T, Fukuda H, Kinjo M, Yamamoto KT: Fluorescence cross-correlation analyses of the molecular interaction between an Aux/IAA protein, MSG2/IAA19, and protein-protein interaction domains of auxin response factors of arabidopsis expressed in HeLa cells. Plant Cell Physiol. 2006 Aug;47(8):1095-101. Epub 2006 Jul 18.


We transiently expressed the C-terminal protein-protein interaction domains (CTDs) of Arabidopsis ARFs, MP/ARF5 and NPH4/ARF7, and MSG2/IAA19, fused to fluorescent proteins in HeLa cells, and determined their molecular interactions with fluorescence cross-correlation spectroscopy (FCCS).
1(0,0,0,1) Details
14973283 Hardtke CS, Ckurshumova W, Vidaurre DP, Singh SA, Stamatiou G, Tiwari SB, Hagen G, Guilfoyle TJ, Berleth T: Overlapping and non-redundant functions of the Arabidopsis auxin response factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4. Development. 2004 Mar;131(5):1089-100.

Here, interaction assays, expression studies and combinations of multiple loss- and gain-of-function mutants were used to assess the roles of two ARFs, NONPHOTOTROPIC HYPOCOTYL 4 (NPH4/ARF7) and MONOPTEROS (MP/ARF5), in Arabidopsis development.
Finally, we demonstrate antagonistic interaction between ARF and Aux/IAA gene functions in Arabidopsis development.
1(0,0,0,1) Details
19363152 Ploense SE, Wu MF, Nagpal P, Reed JW: A gain-of-function mutation in IAA18 alters Arabidopsis embryonic apical patterning. Development. 2009 May;136(9):1509-17.


Genetic interactions among iaa18-1, loss-of-function mutations in ARF (Auxin response factor) genes and ARF-overexpressing constructs suggest that IAA18-1 inhibits activity of MP/ARF5 and other ARF proteins in the apical domain.
1(0,0,0,1) Details
19704497 Sato A, Yamamoto KT: What's the physiological role of domain II-less Aux/IAA proteins? . Plant Signal Behav. 2008 Jul;3(7):496-7.


Because IAA20 and IAA30 were early auxin-inducible and were expressed in the root apical meristem, they may have a physiological role in maintaining the stem cell niche of root, by keeping the activity of MP/ARF5 and NPH4/ARF7 at an acceptable level.
1(0,0,0,1) Details
18258861 Szemenyei H, Hannon M, Long JA: TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis. Science. 2008 Mar 7;319(5868):1384-6. Epub 2008 Feb 7.


Direct interaction between TPL and ARF5/MONOPTEROS, which is regulated by IAA12/BDL, results in a loss-of-function arf5/mp phenotype.
1(0,0,0,1) Details