| Name | DRB1 |
|---|---|
| Synonyms | DRB 1; DRB1; DRBP 1; DRBP1; Developmentally regulated RNA binding protein 1; Putative RNA binding protein RB 1; RB 1; Developmentally regulated RNA binding protein 1s… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12635478 | Kulaeva TL, Titovich EV, Zil'berman LI, Nosikov VV, Peterkova VA, Dedov II: [Genetic and immunologic aspects of type 1 diabetes mellitus] . Usp Fiziol Nauk. 2003 Jan-Mar;34(1):45-62. The study of HLA-DQA1, HLA-DQB1 polymorphic alleles and DRB1 genes and their combinations. |
3(0,0,0,3) | Details |
| 12787001 | Battelino T, Ursic-Bratina N, Dolzan V, Stopar-Obreza M, Pozzilli P, Krzisnik C, Vidan-Jeras B: The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes. Eur J Immunogenet. 2003 Jun;30(3):223-7. The aim of the present study was to determine the frequencies of HLA-DRB-DQB deduced haplotypes associated with susceptibility and protection in Slovenian patients with established T1D, to evaluate the relationship between the HLA-DRB1-QBP-DQB1 haplotypes and the presence of insulin autoantibodies (IAA) and glutamic acid decarboxylase antibodies (GADA), and to access the possible impact of polymorphic QBP promoters on this relationship. |
2(0,0,0,2) | Details |
| 17512892 | Laadhar L, Gassara A, Mahfoudh N, Ben Hadj hmida Y, Kamoun T, Ben Ayed M, Rekik N, Mahfoudh A, Rebai A, Makni H, Abid M, Hachicha M, Masmoudi H: [Susceptibility markers in Tunisian first-degree relatives of patients with type 1 diabetes]. Ann Endocrinol. 2007 Jun;68(2-3):181-5. Epub 2007 May 21. To identify the profile of anti-pancreas autoantibodies and elucidate the HLA DRB1, DQB1 polymorphism in Tunisian first-degree relatives of patients with type 1 diabetes, we recruited 96 relatives from 21 families with at least one diabetic child. |
2(0,0,0,2) | Details |
| 16614815 | Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J: Lymphoid phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia. 2006 Jun;49(6):1198-208. Epub 2006 Apr 14. PTPN22, INS and HLA-DRB1 had an additive effect on the emergence of IAA. |
1(0,0,0,1) | Details |
| 10916559 | Krokowski M, Abel M, Teodorczyk A, Szadkowska A, Pyrzak B, Rymkiewicz-Kluczynska B, Bodalski J: Type 1 diabetes and prediabetic state in a monozygotic triplet. Acta Genet Med Gemellol. 1998;47(3-4):171-6. All patients present identical genotype for VNTR loci: D1S80, D17S5 and Apo B, as well as for HLA-DRB1, -DQA1, -DQB1, CTLA-4 gene and all studied insulin gene polymorphisms. |
1(0,0,0,1) | Details |
| 16025255 | Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lahde J, Simell O, Knip M, Ilonen J: The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. Diabetologia. 2005 Sep;48(9):1766-75. Epub 2005 Jul 16. CONCLUSIONS/INTERPRETATION: The INS and the DRB1 loci appear to contribute to the pathogenesis of type 1 diabetes by initiating/modifying insulin-specific autoimmunity. |
1(0,0,0,1) | Details |