Protein Information

Name caspase 9
Synonyms APAF 3; APAF3; Apoptotic protease MCH6; Apoptotic protease Mch 6; Apoptotic protease activating factor 3; CASP 9; CASP9; CASPASE 9c…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
15855049 Dhar-Mascareno M, Carcamo JM, Golde DW: Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic Biol Med. 2005 May 15;38(10):1311-22.

Since vitamin C is a potent antioxidant and quenches ROS, we investigated the role of intracellular ascorbic acid (iAA) in endothelial cells undergoing hypoxia-reperfusion.
Intracellular AA also prevents loss of mitochondrial membrane potential and the release of cytochrome C and activation of caspase-9 and caspase-3 during H-R.
2(0,0,0,2) Details
14607278 Kim DS, Jeon SE, Park KC: Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal. 2004 Jan;16(1):81-8.


We further investigated the IAA/HRP-mediated apoptotic pathways, and found that IAA/HRP activates caspase-8 and caspase-9, leading to caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details
20225657 Jeong YM, Oh MH, Kim SY, Li H, Yun HY, Baek KJ, Kwon NS, Kim WY, Kim DS: Indole-3-acetic acid/horseradish peroxidase induces apoptosis in TCCSUP human urinary bladder carcinoma cells. Pharmazie. 2010 Feb;65(2):122-6.


We further investigated the IAA/HRP-mediated apoptotic pathways and showed that IAA/HRP induces caspase-8 and caspase-9 activation, which results in caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
1(0,0,0,1) Details