Protein Information

Name activator protein 1
Synonyms AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
19655312 Van Cleemput M, Heyerick A, Libert C, Swerts K, Philippe J, De Keukeleire D, Haegeman G, De Bosscher K: Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. Mol Nutr Food Res. 2009 Sep;53(9):1143-55.


All three studied classes of HBA blocked the tumor necrosis factor alpha (TNF)-induced production of the cytokine IL6, and inhibited the transactivation of the pro-inflammatory transcription factors nuclear factor kappa B (NF-kappaB), activator protein-1 (AP-1), and cAMP-response element-binding protein (CREB).
1(0,0,0,1) Details
9563654 Bae SK, Baek JH, Lee YM, Lee OH, Kim KW: Hypoxia-induced apoptosis in human hepatocellular carcinoma cells: a possible involvement of the 6-TG-sensitive protein kinase (s)-dependent signaling pathway. Cancer Lett. 1998 Apr 10;126(1):97-104.


Hypoxia-induced apoptosis was associated with a marked induction of c-jun and c-fos messenger RNAs.
3(0,0,0,3) Details
15051816 Gietzen DW, Ross CM, Hao S, Sharp JW: Phosphorylation of eIF2alpha is involved in the signaling of indispensable amino acid deficiency in the anterior piriform cortex of the brain in rats. J Nutr. 2004 Apr;134(4):717-23.


In cells intensely labeled for cytoplasmic p-eIF2alpha, there was intense fluorescence for c-Jun in the nucleus.
1(0,0,0,1) Details