| Name | NPPB |
|---|---|
| Synonyms | BNP; BNP 32; Brain natriuretic peptide; Brain natriuretic peptide 32; Gamma brain natriuretic peptide; NPPB; Natriuretic peptide precursor B; Natriuretic peptides B… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9518703 | Doughty JM, Miller AL, Langton PD: Non-specificity of chloride channel blockers in rat cerebral arteries: block of the L-type calcium channel. J Physiol. 1998 Mar 1;507 ( Pt 2):433-9. Under isobaric conditions at 75 mmHg, 5-nitro-2-(3-phenylpropylamino) (NPPB), a chloride channel blocker, reversibly depressed the myogenic constriction with an IC50 of 32.8 +/- 0.52 microM (mean +/- S.E.M., n = 5). |
5(0,0,0,5) | Details |
| 14703716 | Souktani R, Ghaleh B, Tissier R, d'Anglemont de Tassigny A, Aouam K, Bedossa P, Charlemagne D, Samuel J, Henry P, Berdeaux A: Inhibitors of swelling-activated channels increase infarct size and apoptosis in rabbit myocardium. Fundam Clin Pharmacol. 2003 Oct;17(5):555-61. Two I (Cl,swell) blockers, 5-nitro-2-[3-phenylpropylamino] (NPPB) and indanyloxyacetic acid 94 (IAA-94) (both 1 mg/kg), were administered prior to CAO and throughout the 72 h CAR. |
4(0,0,0,4) | Details |
| 19140151 | Boina DR, Bloomquist JR: Toxicity and disruption of midgut physiology in larvae of the European corn borer, Ostrinia nubilalis, by anion transporter blockers. Arch Insect Biochem Physiol. 2009 Mar;70(3):151-61. In this study, four blockers of anion transporters (ATs) belonging to four different classes of organic acids, including DIDS (4, 4'-diisothiocyanatostilbene-2, 2'- disulfonic acid; a stilbene disulfonic acid), NPPB [(5-nitro-2-(3-phenylpropylamino) an 9-AC (anthracene-9-carboxylic acid; an aromatic carboxylic acid), and IAA-94 (indanyloxy an indanyloxy alkanoic acid), were tested for their toxicity against the European corn borer (ECB), Ostrinia nubilalis. |
4(0,0,0,4) | Details |
| 10205144 | Diaz RJ, Losito VA, Mao GD, Ford MK, Backx PH, Wilson GJ: Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium. Circ Res. 1999 Apr 16;84(7):763-75. Indanyloxyacetic acid 94 (IAA-94, 10 micromol/L) or 5-nitro-2-(3-phenylpropylamino) (NPPB, 1 micromol/L) was administered before IP or before SI or SI/SR to inhibit Cl- channels. |
3(0,0,0,3) | Details |
| 14642777 | Jiang J, Backx PH, Teoh H, Ward ME: Role of Cl- currents in rat aortic smooth muscle activation by Eur J Pharmacol. 2003 Nov 28;481(2-3):133-40. The Cl (-) channel antagonists 5-nitro-2-(3-phenylpropylamino) (NPPB), indanyloxyacetic acid-94 (IAA-94) and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) were found to decrease (P <0.05) the maximum tension generated by rat thoracic aortic segments during stimulation with prostaglandin F (2 alpha) and to shift the concentration-response relationship to the right. |
3(0,0,0,3) | Details |
| 18278453 | Li J, Wu X, Cui T: Functional characteristics and molecular identification of swelling-activated conductance in adult rabbit heart ventricles. J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):37-41. The inhibitory effects of 4,4' isothiocyanato-2,2-disulfonic acid (DIDS), 5-nitro-2 (3-phenylroylamino) (NPPB) and indanyloxyacetic acid 94 (IAA-94) on ICl,Swell were examined. |
2(0,0,0,2) | Details |
| 18407564 | Boina DR, Lewis EE, Bloomquist JR: Nematicidal activity of anion transport blockers against Meloidogyne incognita, Caenorhabditis elegans and Heterorhabditis bacteriophora. Pest Manag Sci. 2008 Jun;64(6):646-53. The materials tested were DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid), 9-AC (anthracene-9-carboxylic acid), NPPB [5-nitro-2-(3-phenylpropylamino) and IAA-94 (indanyloxyacetic acid). |
2(0,0,0,2) | Details |
| 10523296 | Szabo I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M: Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J. 1999 Oct 15;18(20):5517-27. VacA-dependent increase of current conduction both in artificial planar lipid bilayers and in the cellular system was effectively inhibited by the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) (NPPB), while2-[(2-cyclopentenyl-6,7dichloro-2, 3-dihydro-2-methyl-1-oxo-1H-inden-5-yl) oxy] (IAA-94) was less effective. |
2(0,0,0,2) | Details |
| 17927776 | Ducharme G, Newell EW, Pinto C, Schlichter LC: Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia. Eur J Neurosci. 2007 Oct;26(8):2119-30. Epub 2007 Oct 1. Using a pharmacological toolbox, we show that all drugs that reduced the microglia current (NPPB, IAA-94, flufenamic acid and DIOA) increased the resting cell volume in isotonic solution and inhibited the regulatory volume decrease that followed cell swelling in hypotonic solution. |
2(0,0,0,2) | Details |
| 16333378 | Dai Y, Tang J, Zhang JH: Role of Cl- in cerebral vascular tone and expression of Na+-K+-2Cl- co-transporter after neonatal hypoxia-ischemia. Can J Physiol Pharmacol. 2005 Aug-Sep;83(8-9):767-73. In the basilar arteries from the New Zealand white rabbits, the role of Cl- flux in -induced contraction was demonstrated by (i) inhibition of Na+-K+-2Cl- co-transporter (NKCC1) to decreased Cl- influx with bumetanide; (ii) a disabled Cl-/HCO3- exchanger with free HEPES solution; (iii) blockade of Cl- channels using 5-nitro-2-(3-phenylpropylamino) (NPPB) and indanyloxyacetic acid 94, R-(+)-methylindazone (R-(+)-IAA-94); and (iv) substitution of extracellular Cl- with methanesulfonate acid (113 mmol/L; Cl-, 10 mmol/L). |
1(0,0,0,1) | Details |
| 11113003 | Heusch G, Liu GS, Rose J, Cohen MV, Downey JM: No confirmation for a causal role of volume-regulated channels in ischemic preconditioning in rabbits. J Mol Cell Cardiol. 2000 Dec;32(12):2279-85. That current could be blocked by the selective chloride channel blockers 5-nitro-2-(3-phenylpropylamino) (NPPB) or indanyloxyacetic acid 94 (IAA-94), but only at 100 microM and 1 m M respectively. |
1(0,0,0,1) | Details |
| 11891568 | Eskandari S, Zampighi GA, Leung DW, Wright EM, Loo DD: Inhibition of gap junction hemichannels by chloride channel blockers. J Membr Biol. 2002 Jan 15;185(2):93-102. Epub 2002 Feb 5. ICx50 was inhibited by 18beta-glycyrrhetinic acid (apparent Ki, 2 microM), gadolinium (3 microM), flufenamic acid (3 microM), niflumic acid (11 microM), NPPB (15 microM), diphenyl-2-carboxylate (26 microM), and (177 microM). |
1(0,0,0,1) | Details |
| 9150469 | Reeves WB: Effects of chloride channel blockers on hypoxic injury in rat proximal tubules. Kidney Int. 1997 May;51(5):1529-34. Other Cl- channel blockers, such as niflumic acid, 5-nitro-2-(3-phenylpropylamino)- (NPPB) and 2-[(2-cyclopentyl-6,7-dichloro-2,3-dihyrdo-2-methyl-1-oxo-1H-in den-5-yl) oxy] (IAA-94) provided even greater protection than DPC and were as effective as 2 mM |
1(0,0,0,1) | Details |
| 18837047 | Ye ZC, Oberheim N, Kettenmann H, Ransom BR: Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. Glia. 2009 Feb;57(3):258-69. The typical VRAC blockers, NPPB, IAA-94, and tamoxifen blocked low divalent cation-induced and release and LY loading, presumed due to hemichannel opening. |
1(0,0,0,1) | Details |
| 9309212 | Thomine S, Guern J, Barbier-Brygoo H: Voltage-dependent anion channel of Arabidopsis hypocotyls: nucleotide regulation and pharmacological properties. J Membr Biol. 1997 Sep 1;159(1):71-82. It is inhibited by niflumic acid with an IC50 of 80 microM, but poorly sensitive to IAA-94 and NPPB and insensitive to 9-AC and DIDS. |
1(0,0,0,1) | Details |
| 15482374 | d'Anglemont de Tassigny A, Souktani R, Henry P, Ghaleh B, Berdeaux A: Volume-sensitive channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. Fundam Clin Pharmacol. 2004 Oct;18(5):531-8. Doxorubicin-induced AVD and apoptosis were both abolished when cardiomyocytes were exposed to the I (Cl,vol) inhibitors 5-nitro-2-(3-phenylpropylamino) (NPPB) (0.1 mM) or indanyloxyacetic acid 94 (IAA-94) (10 microM). |
1(0,0,0,1) | Details |
| 9199781 | Clark AG, Murray D, Ashley RH: Single-channel properties of a rat brain endoplasmic reticulum anion channel. Biophys J. 1997 Jul;73(1):168-78. The channels were inactivated by 15 microM 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) and blocked with low affinity (KD of 1-100 microM) by anthracene-9-carboxylic acid, ethacrynic acid, HEPES, the indanyloxyacetic acid derivative IAA-94, 5-nitro-2-(3-phenylpropylamino)- (NPPB), and Zn2+. |
1(0,0,0,1) | Details |
| 15321730 | Doroshenko N, Doroshenko P: The glutathione reductase inhibitor carmustine induces an influx of Ca2+ in PC12 cells. Eur J Pharmacol. 2004 Aug 16;497(1):17-24. The increase in [Ca (2+)](i) was also suppressed in Cl (-)-free solution and in the presence of the Cl (-) channel blockers, indanyloxyacetic acid 94 (IAA-94, 100 microM) and 5-nitro-2-(3-phenylpropylamino) (NPPB, 100 microM). |
1(0,0,0,1) | Details |