| Name | IA 2 |
|---|---|
| Synonyms | IA 2; IA 2/PTP; IA2; ICA 512; ICA 3; ICA3; ICA512; Islet cell antigen 512… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11416235 | Bilbao JR, Rica I, Vazquez JA, Busturia MA, Castano L: Influence of sex and age at onset on autoantibodies against insulin, GAD65 and IA2 in recent onset type 1 diabetic patients. Horm Res. 2000;54(4):181-5. |
2(0,0,0,2) | Details |
| 19885806 | Siewko K, Szelachowska M, Poplawska-Kita A, Szpak P, Nikolajuk A, Gorska M: [The C-peptide as a risk factor of development of type 1 diabetes in the first degree relatives of the autoimmunological diabetic patients]. Endokrynol Pol. 2009 Sep-Oct;60(5):357-62. The aim of the study was to evaluate the fasting level of the C-peptide, depending on immunological markers presence (anti-GAD, IAA and anti-IA2 antibodies) and usefulness of this parameter in the risk assessment of development of type 1 diabetes in the first degree relatives of autoimmunological diabetic patients. |
2(0,0,0,2) | Details |
| 10823007 | Luyckx FH, Delcour S, Philips JC, Scheen AJ: [The dosage of anti-GAD and anti-IA2 autoantibodies: an aid to the early diagnosis of type 1 diabetes]. Diabetes. 2001 Nov;50(11):2451-8. |
2(0,0,0,2) | Details |
| 15016223 | Hathout EH, Sharkey J, Racine M, Thomas W, Nahab F, El-Shahawy M, Mace JW: Diabetic autoimmunity in infants and pre-schoolers with type 1 diabetes. Pediatr Diabetes. 2000 Sep;1(3):131-4. To determine the prevalence of diabetes autoimmune markers, ICA512, GAD65 and insulin autoantibodies (IAA) antibodies were measured. |
2(0,0,0,2) | Details |
| 11221998 | Maniatis AK, Yu L, Miao D, Nelson K, Eisenbarth GS: Rapid assays for detection of anti-islet autoantibodies: implications for organ donor screening. J Autoimmun. 2001 Feb;16(1):71-6. The purpose of the current study was to develop and evaluate rapid assays for autoantibodies to GAD65 (GAA), ICA512bdc/IA-2 (ICA512AA), and insulin (microIAA, mIAA) as a potential tool for identification of cadaveric pancreas donors who were at high risk for developing diabetes. |
1(0,0,0,1) | Details |
| 11393549 | Ito T, Nakamura K, Umeda E, Kaino Y, Hirai H, Kida K, Mimura G: Familial predisposition of type 1 diabetes mellitus in Japan, a country with low incidence. J Pediatr Endocrinol Metab. 2001;14 Suppl 1:589-95. The rate of positivity for autoantibodies, including ICA, IAA, GAD and IA-2, was 1.4-2.9% in parents (n=140) and 2.0-3.9% in siblings (n=203). |
1(0,0,0,1) | Details |
| 11921419 | Hamalainen AM, Ilonen J, Simell O, Savola K, Kulmala P, Kupila A, Simell T, Erkkola R, Koskela P, Knip M: Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers. Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):57-63. METHODS: The samples were analysed for cytoplasmic islet cell antibodies (ICA), autoantibodies to the 65 kD isoform of glutamic acid decarboxylase (GADA), autoantibodies to the protein tyrosine phosphatase related IA-2 antigen (IA-2A), insulin autoantibodies (IAA) and HLA DQB1 genotypes. |
1(0,0,0,1) | Details |
| 10209508 | Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vahasalo P, Karjalainen J, Ilonen J, Akerblom HK, Knip M: Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Clin Exp Immunol. 1999 Apr;116(1):78-83. The possible relation between HLA-DQ genotypes and both frequencies and levels of autoantibodies associated with IDDM was assessed by examining HLA-DQB1 alleles and antibodies to islet cells (ICA), insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase-related IA-2 molecule (IA-2A) in 631 newly diagnosed diabetic children under the age of 15 years. |
2(0,0,0,2) | Details |
| 12116176 | Knip M, Kukko M, Kulmala P, Veijola R, Simell O, Akerblom HK, Ilonen J: Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. Am J Med Genet. 2002 May 30;115(1):48-54. Among the newly diagnosed patients we observed that those carrying the DR4-DQB1*0302 haplotype had increased levels of insulin autoantibodies (IAA) and IA-2 antibodies (IA-2A), but low levels of GAD antibodies (GADA). |
2(0,0,0,2) | Details |
| 11437866 | Bosi E, Minelli R, Bazzigaluppi E, Salvi M: Fulminant autoimmune Type 1 diabetes during interferon-alpha therapy: a case of Th1-mediated disease?. Diabet Med. 2001 Apr;18(4):329-32. HLA class II molecular typing was determined and retrospective measurement of islet cell (ICA), decarboxylase (GADA), tyrosin phosphatase IA-2 (IA-2A) and insulin (IAA) antibodies was performed in serum samples obtained before and at 0.5, 1, 2, 3, 4, 5, 6, 8.5, 10 and 13 months after the beginning of IFN-alpha treatment. |
1(0,0,0,1) | Details |
| 12898016 | Cabrera-Rode E, Sarmiento L, Tiberti C, Molina G, Barrios J, Hernandez D, Diaz-Horta O, Di Mario U: Type 1 diabetes islet associated antibodies in subjects infected by echovirus 16. Diabetologia. 2003 Oct;46(10):1348-53. Epub 2003 Jul 29. METHODS: The presence of ICA, IAA, GADA, IA2 antibodies and neutralizing antibodies (NtAb) to echovirus 16 were determined in sera from 38 infected children and adolescents and 80 control subjects, matched in sex, age, local residence and time of sample collection. |
1(0,0,0,1) | Details |
| 16280641 | Aly T, Devendra D, Eisenbarth GS: Immunotherapeutic approaches to prevent, ameliorate, and cure type 1 diabetes. Am J Ther. 2005 Nov-Dec;12(6):481-90. Insulin, glutamic acid decarboxylase, and insulinoma associated-2 autoantibodies (IAA, GAD65, and IA-2) are the autoantibodies that have been associated most clearly with the development of T1D. |
1(0,0,0,1) | Details |
| 11729828 | Kretowski A, Mysliwiec J, Szelachowska M, Brzozowski C, Pietruczuk M, Kinalska I: In vitro secretion of interleukin 2 and expression of IL-2 receptor in peripheral blood lymphocytes in high risk of insulin-dependent diabetes mellitus subjects. Arch Immunol Ther Exp. 1999;47(1):45-9. In 27 first degree relatives of IDDM patients with antibodies against different pancreatic islet cell antigens (ICA, GADA, IAA, IA-2) CD25 antigen expression on peripheral blood lymphocytes T was measured by flow cytometry and IL-2 concentration in supernatants of 48 and 72 h cultures of peripheral whole blood with 10 microg/ml PHA was estimated by ELISA. |
1(0,0,0,1) | Details |
| 9562346 | Savola K, Bonifacio E, Sabbah E, Kulmala P, Vahasalo P, Karjalainen J, Tuomilehto-Wolf E, Merilainen J, Akerblom HK, Knip M: IA-2 antibodies--a sensitive marker of IDDM with clinical onset in childhood and adolescence. Diabetologia. 1998 Apr;41(4):424-9. |
2(0,0,0,2) | Details |
| 20040655 | Cambuli VM, Incani M, Cossu E, Congiu T, Scano F, Pilia S, Sentinelli F, Tiberti C, Cavallo MG, Loche S, Baroni MG: Prevalence of type 1 diabetes autoantibodies (GADA, IA2, and IAA) in overweight and obese children. Diabetes Care. 2010 Apr;33(4):820-2. Epub 2009 Dec 29. |
2(0,0,0,2) | Details |
| 15756536 | Decochez K, Truyen I, van der Auwera B, Weets I, Vandemeulebroucke E, de Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Pipeleers DG, Gorus FK: Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes. Autoimmun Rev. 2006 Jul;5(6):424-8. Epub 2005 Dec 29. |
2(0,0,0,2) | Details |
| 19741189 | Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R, Yu L, Palmer JP, Schatz D, Eisenbarth G: Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care. 2009 Dec;32(12):2269-74. Epub 2009 Sep 9. Autoantibodies to GAD 65 (GAD65), insulinoma-associated antigen-2 (ICA512), and insulin (micro-IAA [mIAA]) were also measured. |
2(0,0,0,2) | Details |
| 9353155 | Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK: CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. Clin Exp Immunol. 1997 Oct;110(1):98-103. In a registry-based group of 525 recent-onset IDDM patients <40 years old we investigated the possible interactions of a CTLA-4 gene A-to-G transition polymorphism with age at clinical disease onset and with the presence or absence of established genetic (HLA-DQ, INS VNTR) and immune disease markers (autoantibodies against islet cell cytoplasm (ICA); insulin (IAA); decarboxylase (GAD65-Ab); IA-2 protein tyrosine phosphatase (IA-2-Ab)) determined within the first week of insulin treatment. |
1(0,0,0,1) | Details |
| 15872335 | Kukko M, Kimpimaki T, Korhonen S, Kupila A, Simell S, Veijola R, Simell T, Ilonen J, Simell O, Knip M: Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population. J Clin Endocrinol Metab. 2005 May;90(5):2712-7. Epub 2005 Feb 15. This study characterized the dynamics of islet cell antibodies (ICA), insulin antibodies (IAA), glutamic acid decarboxylase antibodies (GADA), and IA-2 antibodies (IA-2A) in 1006 children recruited from the general population due to human leukocyte antigen (HLA) DQB1-conferred risk for type 1 diabetes (T1D). |
1(0,0,0,1) | Details |
| 10916559 | Krokowski M, Abel M, Teodorczyk A, Szadkowska A, Pyrzak B, Rymkiewicz-Kluczynska B, Bodalski J: Type 1 diabetes and prediabetic state in a monozygotic triplet. Acta Genet Med Gemellol. 1998;47(3-4):171-6. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum precedes the clinical onset of the disease. |
1(0,0,0,1) | Details |
| 16442659 | Holmberg H, Vaarala O, Sadauskaite-Kuehne V, Ilonen J, Padaiga Z, Ludvigsson J: Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes. Diabetes Res Clin Pract. 2006 Jun;72(3):308-14. Epub 2006 Jan 26. We analyzed autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase like IA-2 (IA-2A) as well as risk-associated polymorphisms of HLA, insulin and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) genes. |
1(0,0,0,1) | Details |
| 16100734 | Kukko M, Toivonen A, Kupila A, Korhonen S, Keskinen P, Veijola R, Virtanen SM, Ilonen J, Simell O, Knip M: Familial clustering of beta-cell autoimmunity in initially non-diabetic children. Diabetes Metab Res Rev. 2006 Jan-Feb;22(1):53-8. When a child tested positive for ICA, all his/her previous or subsequent samples that were available were also tested for insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA) and antibodies to the IA-2 protein (IA-2A). |
1(0,0,0,1) | Details |
| 9754810 | Schmidli RS, Colman PG, Cui L, Yu WP, Kewming K, Jankulovski C, Harrison LC, Pallen CJ, DeAizpurua HJ: Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM. Autoimmunity. 1998;28(1):15-23. |
9(0,0,0,9) | Details |
| 17130560 | Gupta M, Graham J, McNeeny B, Zarghami M, Landin-Olsson M, Hagopian WA, Palmer J, Lernmark A, Sanjeevi CB: MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus. Ann N Y Acad Sci. 2006 Oct;1079:229-39. In type 1 diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. |
6(0,0,0,6) | Details |
| 11192752 | Cinek O, Pechova M, Kolouskova S, Horka I, Sedlakova P, Sumnik Z, Snajderova M, Vavrinec J: [Autoantibodies to GAD65, IA2 and insulin in Czech children with type 1 diabetes]. Cas Lek Cesk. 2000 Sep 27;139(19):599-603. |
5(0,0,0,5) | Details |
| 10330299 | Maclaren N, Lan M, Coutant R, Schatz D, Silverstein J, Muir A, Clare-Salzer M, She JX, Malone J, Crockett S, Schwartz S, Quattrin T, DeSilva M, Vander Vegt P, Notkins A, Krischer J: Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives. J Autoimmun. 1999 Jun;12(4):279-87. |
1(0,0,0,1) | Details |
| 15826926 | Falorni A, Brozzetti A: Diabetes-related antibodies in adult diabetic patients. Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):119-33. Islet autoimmunity is made evident by the appearance of islet-cell antibodies directed against insulin (IAA), glutamic acid decarboxylase (GADA), protein tyrosine phosphatase IA-2 (IA-2Ab) and other autoantigens. |
1(0,0,0,1) | Details |
| 17217566 | Holmberg H, Wahlberg J, Vaarala O, Ludvigsson J: Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population. Br J Nutr. 2007 Jan;97(1):111-6. Autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tryosine phosphatase-like IA-2 (IA-2A) were measured by radiobinding assays. |
1(0,0,0,1) | Details |
| 10047433 | Kasuga A, Maruyama T, Nakamoto S, Ozawa Y, Suzuki Y, Saruta T: High-titer autoantibodies against glutamic acid decarboxylase plus autoantibodies against insulin and IA-2 predicts insulin requirement in adult diabetic patients. J Autoimmun. 1999 Mar;12(2):131-5. |
1(0,0,0,1) | Details |
| 11474874 | Krochik AG, Mazza CS, Valdez SN, Stumpo RR, Papouchado ML, Iacono RF, Cardoso Landaburu AC, Sica MP, Ozuna B, Poskus E: Immunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population. Medicina (B Aires). 2001;61(3):279-83. The objective was to evaluate the prevalence and association of several markers (islet cell antibodies: ICA, insulin autoantibodies: IAA, glutamic acid decarboxylase antibodies: GADA and ICA512 antibodies: ICA512A) along with HLA DQB1 genotype in type 1 diabetes mellitus of recent onset, including siblings and individuals without any history of this disease, in an Argentine population. |
1(0,0,0,1) | Details |
| 18193190 | Achenbach P, Bonifacio E, Williams AJ, Ziegler AG, Gale EA, Bingley PJ: Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives. Int J Exp Diabetes Res. 2001;2(2):85-90. METHODS: Autoantibodies to insulin (IAA), decarboxylase (GADA) and IA-2 (IA2A) were measured in 549 participants at study entry, and IA2A-positive samples tested for IA2betaA. |
1(0,0,0,1) | Details |
| 11510200 | Perez-Bravo F, Riesco V, Albala C, Oyarzun A, Santos JL, Carrasco E: [Auto-antibody profile and breast feeding in type 1 diabetic patients] . Rev Med Chil. 2001 Jun;129(6):611-9. BACKGROUND: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti- phosphatase (IA2) can be present in patients with type I diabetes. |
5(0,0,0,5) | Details |
| 10546010 | Bingley PJ, Williams AJ, Gale EA: Optimized autoantibody-based risk assessment in family members. Diabetes Care. 1999 Nov;22(11):1796-801. RESEARCH DESIGN AND METHODS: ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determined in serum samples at study entry of 3,655 non-diabetic first-degree relatives of patients with type 1 diabetes who were followed for a median of 5.5 years. |
5(0,0,0,5) | Details |
| 10382585 | Strebelow M, Schlosser M, Ziegler B, Rjasanowski I, Ziegler M: Karlsburg Type I diabetes risk study of a general population: frequencies and interactions of the four major Type I diabetes-associated autoantibodies studied in 9419 schoolchildren. Diabetologia. 1999 Jun;42(6):661-70. CONCLUSION/INTERPRETATION: For children older than 5 years the combined anti-GAD/IA2 test with cut-off at or greater than the 98th centile should be used for primary screening followed by testing for IAA and ICA. |
1(0,0,0,1) | Details |
| 9878086 | Yamamoto AM, Deschamps I, Garchon HJ, Roussely H, Moreau N, Beaurain G, Robert JJ, Bach JF: Young age and HLA markers enhance the risk of progression to type 1 diabetes in antibody-positive siblings of diabetic children. J Autoimmun. 1998 Dec;11(6):643-50. We evaluated islet cell antibodies (ICA) by indirect immunofluorescence and autoantibodies to insulin (IAA), to the 65 kDa isoform of glutamic acid decarboxylase (GADA) and to the IA-2 protein (IA-2A) by radioligand assay in sequential serum samples. |
1(0,0,0,1) | Details |
| 9435304 | Kulmala P, Savola K, Petersen JS, Vahasalo P, Karjalainen J, Lopponen T, Dyrberg T, Akerblom HK, Knip M: Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. J Clin Invest. 1998 Jan 15;101(2):327-36. An unselected population of 755 siblings of children with insulin-dependent diabetes mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies (ICA), antibodies to the IA-2 protein (IA-2A), antibodies to the 65-kD isoform of glutamic acid decarboxylase (GADA), insulin autoantibodies (IAA), and combinations of these markers. |
1(0,0,0,1) | Details |
| 16890898 | Wasserfall CH, Atkinson MA: Autoantibody markers for the diagnosis and prediction of type 1 diabetes. Diabetologia. 2008 Mar;51(3):488-92. Epub 2008 Jan 9. While autoantibodies to more than two dozen autoantigens have been associated with this disease, a majority of interest has been directed at four autoantibodies; islet cell cytoplasmic (ICA), insulin (IAA), glutamic acid decarboxylase (GADA), and IA2/ICA512 autoantigen (IA2A). |
1(0,0,0,1) | Details |
| 18573919 | Makinen A, Harkonen T, Ilonen J, Knip M: Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes. Eur J Endocrinol. 2008 Jul;159(1):19-26. OBJECTIVE: To characterize the humoral immune response to islet antigen 2 (IA-2) in patients with newly diagnosed type 1 diabetes (T1D), we compared the profile of epitope- and isotype-specific IA-2 antibodies (IA-2A) between children with a humoral immune response restricted to IA-2 and children with a broad response including insulin autoantibodies (IAA) and antibodies to glutamic acid decarboxylase (GADA) in addition to IA-2A. |
5(0,0,0,5) | Details |
| 10479394 | Sera Y, Kawasaki E, Abiru N, Ozaki M, Abe T, Takino H, Kondo H, Yamasaki H, Yamaguchi Y, Akazawa S, Nagataki S, Uchigata Y, Matsuura N, Eguchi K: Autoantibodies to multiple islet autoantigens in patients with abrupt onset type 1 diabetes and diabetes diagnosed with urinary screening. Rev Med Liege. 2000 Mar;55(3):169-75. To elucidate the associations of expression of autoantibodies to multiple islet antigens with age of onset and mode of diagnosis of diabetes in Japanese patients with type 1 diabetes, autoantibodies against the protein tyrosine phosphatase-like molecules ICA512 (IA-2) and phogrin (IA-2beta) (ICA512/phogrin-A), GAD (GADA), insulin (IAA), and islet cell cytoplasm (ICA) were determined in sera from 73 Japanese patients with type 1 diabetes obtained within 14 days of diagnosis. |
5(0,0,0,5) | Details |
| 12017227 | Umpaichitra V, Banerji MA, Castells S: Autoantibodies in children with type 2 diabetes mellitus. . J Pediatr Endocrinol Metab. 2002 Apr;15 Suppl 1:525-30. To evaluate the frequency of autoantibodies to glutamic acid decarboxylase (GAD), protein tyrosine phosphatase-like protein (IA-2), and insulin (IAA) in children with type 2 diabetes mellitus (DM), we studied 37 children and adolescents whose type 2 DM was defined by fasting and 90-min standard liquid meal-stimulated serum C-peptide levels of > 0.2 and > 0.5 nmol/l (0.7 and 1.5 ng/ml), respectively. |
5(0,0,0,5) | Details |
| 15065337 | Buczkowska EO, Chobot PJ: [Immune markers of type-I diabetes mellitus in children with diabetes in their first-degree relatives. Przegl Lek. 2003;60(9):580-4. During its progression such autoantibodies as ICA, anti-GAD, anti-IA2 and IAA are found. |
1(0,0,0,1) | Details |
| 15016154 | Colman PG, McNair PD, Gellert S, Kewming K, Schmidli RS, Steele CE, Harrison LC: Development of autoantibodies to islet antigens during childhood: implications for preclinical type 1 diabetes screening. Pediatr Diabetes. 2002 Sep;3(3):144-8. Of 423 who were eligible, 350 consented to re-testing for ICA and IAA and antibodies to glutamic acid decarboxylase (GADAb) and phosphatase-like insulinoma antigen IA-2 (IA2Ab) at a mean age of 11.1 yr. |
1(0,0,0,1) | Details |
| 12930364 | Viskari H, Paronen J, Keskinen P, Simell S, Zawilinska B, Zgorniak-Nowosielska I, Korhonen S, Ilonen J, Simell O, Haapala AM, Knip M, Hyoty H: Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome. Clin Exp Immunol. 2003 Sep;133(3):378-83. The incidence of clinical diabetes, thyroid disease, coeliac disease and related antibodies (islet cell antibodies, ICA; insulin autoantibodies, IAA; antibodies to the phosphatase related IA-2 molecule, IA-2 A and glutamic acid decarboxylase, GADA; thyroid peroxidase, TPO; tissue transglutaminase, TTGA; and gliadin, AGA) and HLA risk genotypes were analysed in 37 subjects affected by or exposed to rubella during fetal life (mean age 22.5 years). |
1(0,0,0,1) | Details |
| 12827008 | Crone J, Rami B, Huber WD, Granditsch G, Schober E: Prevalence of celiac disease and follow-up of EMA in children and adolescents with type 1 diabetes mellitus. J Pediatr Gastroenterol Nutr. 2003 Jul;37(1):67-71. Thyroid peroxidase (TPO), thyroglobulin (TgA), decarboxylase (GAD), antiinsulin (IAA), and islet cell antibodies (IA2) were measured in all patients. |
1(0,0,0,1) | Details |
| 10078544 | Ziegler AG, Hummel M, Schenker M, Bonifacio E: Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes. 1999 Mar;48(3):460-8. Islet cell antibodies (ICAs) and autoantibodies to insulin (IAAs), glutamic acid decarboxylase, and IA-2 were measured at birth, 9 months, 2 years, and 5 years of age. |
1(0,0,0,1) | Details |
| 20091020 | De Grijse J, Asanghanwa M, Nouthe B, Albrecher N, Goubert P, Vermeulen I, Van Der Meeren S, Decochez K, Weets I, Keymeulen B, Lampasona V, Wenzlau J, Hutton JC, Pipeleers D, Gorus FK: Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. Diabetologia. 2010 Mar;53(3):517-24. Epub 2009 Nov 29. AIMS/HYPOTHESIS: We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been based on assays for insulin autoantibodies (IAA), GAD autoantibodies (GADA) and IA-2 autoantibodies (IA-2A). |
1(0,0,0,1) | Details |
| 15016155 | Borg H, Marcus C, Sjoblad S, Fernlund P, Sundkvist G: Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age. Pediatr Diabetes. 2002 Sep;3(3):149-54. OBJECTIVE: To relate IAA to islet antibodies (i.e., islet cell antibodies [ICA], and antibodies against two ICA-related islet antigens, glutamic acid decarboxylase 65 [GADA] and protein tyrosine phosphatase IA-2 [IA-2 A]) at diagnosis, and to endogenous beta-cell function at follow-up after diagnosis in diabetic children. |
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| 11134089 | Gylling M, Tuomi T, Bjorses P, Kontiainen S, Partanen J, Christie MR, Knip M, Perheentupa J, Miettinen A: ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2000 Dec;85(12):4434-40. Autoantibodies against the IA-2 phosphatase-like protein (IA-2 ab) or insulin (IAA) have been suggested to be better markers for active ss-cell destruction. |
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| 10587824 | Komulainen J, Kulmala P, Savola K, Lounamaa R, Ilonen J, Reijonen H, Knip M, Akerblom HK: Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Diabetes Care. 1999 Dec;22(12):1950-5. RESEARCH DESIGN AND METHODS: Clinical outcome, islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies against GAD (GADA), IA-2 antibodies (IA-2A), and HLA-DQB1-defined genetic risk were analyzed in 35 children diagnosed with type 1 diabetes before 2 years of age and compared with those in 146 children who were diagnosed between 2.0 and 4.9 years of age and with those in 620 children diagnosed between 5.0 and 14.9 years of age. |
1(0,0,0,1) | Details |
| 10937518 | Betterle C, Fabris P, Zanchetta R, Pedini B, Tositti G, Bosi E, de Lalla F: Autoimmunity against pancreatic islets and other tissues before and after interferon-alpha therapy in patients with hepatitis C virus chronic infection. Diabetes Care. 2000 Aug;23(8):1177-81. Autoantibodies to GAD (GADAb), second islet cell autoantigen (IA2-Ab), and insulin (IAA) were tested by radioimmunoassay and thyroid microsomal autoantibodies (TMHA) and thyroglobulin autoantibodies (TGHA) were assessed by hemoagglutination test. |
1(0,0,0,1) | Details |
| 14747235 | Stanley HM, Norris JM, Barriga K, Hoffman M, Yu L, Miao D, Erlich HA, Eisenbarth GS, Rewers M: Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY). Diabetes Care. 2004 Feb;27(2):497-502. RESEARCH DESIGN AND METHODS: Cord blood sera from 1,118 subjects from the Diabetes Autoimmunity Study in the Young (DAISY) cohort, as well as their venous blood samples taken at follow-up clinic visits, were tested for GAD65 autoantibodies (GAAs), insulin autoantibodies (IAAs), and IA-2 autoantibodies (IA-2As). |
1(0,0,0,1) | Details |
| 18282420 | Xin Y, Zhao YQ, Zhao YX, Zhang LH: [The changes of serum interferon-inducible protein-10 levels in children with type 1 diabetes mellitus]. Zhonghua Er Ke Za Zhi. 2007 Nov;45(11):853-5. METHODS: Serum IP-10 levels were measured by ELISA in 50 children with T1DM and 30 healthy children, and the levels of autoantibodies [glutamic acid decarboxylase (GAD), isle tcell antibody (ICA), insulin autoantibody (IAA) and phosphatase (IA-2)] in diabetic children were measured as well. |
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| 10645715 | Panczel P, Kulkey O, Luczay A, Bornemisza B, Illyes G, Halmos T, Baranyi E, Blatniczky L, Meszaros J, Kerenyi Z, Gero L, Tamas G, Hosszufalusi N, Horvath L, Madacsy L, Romics L: [Detection of antibodies against pancreatic islet cells in clinical practice]. Orv Hetil. 1999 Nov 28;140(48):2695-701. The glutamic acid decarbocylase (GAD), the tyrosin phosphatase (IA2), the insulin, and the -1 glycolipid can be the targets of these antibodies. |
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| 12442065 | Thivolet C, Nicolino M, Monbeig S, Estour B, Halimi S, Robert M, Orgiazzi J, Chatelain P: Combination of autoantibody markers and risk for development of type 1 diabetes: results from a large french cohort of family members. Diabetes Metab. 2002 Sep;28(4 Pt 1):279-85. Antibodies to insulin, GAD and IA-2 as well as ICA were examined in 4,044 family members recruited in a large prospective family study in the Rhone-Alpes region (the GRADI study). |
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| 16297055 | Dieterle CD, Hierl FX, Gutt B, Arbogast H, Meier GR, Veitenhansl M, Hoffmann JN, Landgraf R: Insulin and islet autoantibodies after pancreas transplantation. Transpl Int. 2005 Dec;18(12):1361-5. We studied the prevalence of autoantibodies to insulin (IAA), decarboxylase (GAD) and phosphatase (IA-2) as well as parameters of pancreas graft function. |
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| 12364437 | Kimpimaki T, Kulmala P, Savola K, Kupila A, Korhonen S, Simell T, Ilonen J, Simell O, Knip M: Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population. J Clin Endocrinol Metab. 2002 Oct;87(10):4572-9. The aim of this study was to evaluate the frequency and predictive value of diabetes-associated autoantibodies, such as islet cell antibodies (ICA) and autoantibodies to insulin (IAA), GAD65 (GADA), and the IA-2 molecule (IA-2A) in genetically susceptible children from the general population during the first 2 yr of life. |
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| 12519837 | Krischer JP, Cuthbertson DD, Yu L, Orban T, Maclaren N, Jackson R, Winter WE, Schatz DA, Palmer JP, Eisenbarth GS: Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab. 2003 Jan;88(1):103-8. The objective of this study was to determine the extent to which different screening strategies could identify a population of nondiabetic relatives of a proband with type 1 diabetes who had two or more immunologic markers from the group consisting of islet cell antibodies (ICA), micro insulin autoantibodies (MIAA), GAD65 autoantibodies (GAA), and ICA512 autoantibodies (ICA512AA). |
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| 9727889 | Pastore MR, Bazzigaluppi E, Bonfanti R, Dozio N, Sergi A, Balini A, Belloni C, Meschi F, Bonifacio E, Bosi E: Two-step islet autoantibody screening for risk assessment of type 1 diabetes in relatives. Diabetes Care. 1998 Sep;21(9):1445-50. OBJECTIVE: To examine the performance of islet cell antibodies (ICAs) and antibodies to decarboxylase (GADA), IA-2 (IA-2 antibody [IA-2A]), and insulin (insulin autoantibody [IAA]), alone and in combination, in assessing type 1 diabetes risk within type 1 diabetic families to identify a practical and effective screening strategy for predicting type 1 diabetes in relatives. |
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| 9433472 | Rulli M, Kuusisto A, Salo J, Kojola H, Simell O: Time-resolved fluorescence imaging in islet cell autoantibody quantitation. J Immunol Methods. 1997 Oct 27;208(2):169-79. Of 57 consecutive new-onset IDDM patients, 55 (96.5%) were ICA positive in the new assay while 51 (89.5%) were positive in the conventional assay suggesting that the sensitivity of TRFI exceeds that of the IAA, GAD65 and IA-2 autoantibody assays combined. |
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| 10808061 | Schiel R, Muller UA: GAD autoantibodies in a selection-free population of insulin-treated diabetic patients: indicator of a high prevalence of LADA?. Diabetes Res Clin Pract. 2000 Jul;49(1):33-40. Up to the present only few data have been available concerning the prevalence of diabetes-specific autoantibodies (anti-GAD, ICA, IAA, IA-2) in unselected populations, in particular in type 2 diabetic patients. |
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| 11200711 | Nazaimoon WM, Azmi KN, Rasat R, Ismail IS, Singaraveloo M, Mohamad WB, Letchuman R, Sheriff IH, Faridah I, Khalid BA: Autoimmune markers in young Malaysian patients with type 1 diabetes mellitus. Med J Malaysia. 2000 Sep;55(3):318-23. This study determined the prevalence and significance of autoantibodies to GAD65 (GAD Ab), insulin (IAA), -like phosphatase (IA2) and islet-cell (ICA) in a group of 213 young Malaysian Type 1 diabetics, diagnosed before the age of 40 years. |
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| 14747289 | Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, Bonifacio E, Ziegler AG: Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes. 2004 Feb;53(2):384-92. Family history of type 1 diabetes and autoantibodies to the islet antigens insulin (IAA), decarboxylase (GADA), and the protein tyrosine phosphatase-like protein IA-2 (IA-2A) are strong predictors of type 1 diabetes, but the rate of progression to diabetes in multiple islet autoantibody-positive relatives varies widely. |
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| 12488955 | Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK: IA-2 autoantibodies predict impending type I diabetes in siblings of patients. Diabetologia. 2002 Dec;45(12):1658-66. Epub 2002 Nov 12. |
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| 10720050 | Kimpimaki T, Kulmala P, Savola K, Vahasalo P, Reijonen H, Ilonen J, Akerblom HK, Knip M: Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. J Clin Endocrinol Metab. 2000 Mar;85(3):1126-32. All siblings were younger than 6 yr of age at the initial sampling, and they were monitored for the emergence of islet cell antibodies (ICA), insulin autoantibodies (IAA), decarboxylase antibodies (GADA), and IA-2 antibodies (IA-2A) up to the age of 6 yr and for progression to clinical type 1 diabetes up to the age of 10 yr. |
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| 11679421 | Bonifacio E, Atkinson M, Eisenbarth G, Serreze D, Kay TW, Lee-Chan E, Singh B: International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice. Ann Endocrinol. 2007 Jun;68(2-3):181-5. Epub 2007 May 21. GAD autoantibody (GADA) and IA-2 autoantibody (IA-2A) signals obtained by RBA were low (maximum 2.5% of total) but were increased in NOD mice compared with control mice at diabetes onset (GADA 29-50%; IA-2A 36-47%). |
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| 15386804 | Larsson K, Elding-Larsson H, Cederwall E, Kockum K, Neiderud J, Sjoblad S, Lindberg B, Lernmark B, Cilio C, Ivarsson SA, Lernmark A: Genetic and perinatal factors as risk for childhood type 1 diabetes. Diabetologia. 2005 Apr;48(4):687-94. Epub 2005 Mar 9. Cord blood is analysed for HLA high-risk alleles and for autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GADA), the protein tyrosine phosphatase-related IA-2 antigen (IA-2A) and insulin (IAA) as a measure of prenatal autoimmune exposure. |
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| 17381505 | Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T: Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission. Diabet Med. 2007 May;24(5):512-20. Epub 2007 Mar 22. In addition, autoantibodies against insulin (IAA), IA-2 (IA-2A) and GAD65 (GADA) were quantified. |
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| 10554570 | Kinalski M, Kretowski A, Telejko B, Kowalska I, Bingley P, Kinalska I: [Prevalence of ICA antibodies, anti-GAD and antylA-2 in women with gestational diabetes treated with diet]. Przegl Lek. 1999;56(5):342-6. Nowadays, on the basis of a detection of antibodies against islet cells (ICA, anti GAD, IA-2 IAA), we can recognize autoimmune disorders typical for the type I diabetes. |
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| 18588707 | Murgia C, Orru M, Portoghese E, Garau N, Zedda P, Berria R, Motzo C, Sulis S, Murenu M, Paoletti AM, Melis GB: Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Reprod Biol Endocrinol. 2008 Jun 29;6:24. METHODS: We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity. |
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| 11921417 | Korhonen S, Knip MM, Kulmala P, Savola K, Akerblom HK, Knip M: Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings. Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):43-8. |
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| 10909282 | Kretowski A, Kowalska I, Peczynska J, Urban M, Kinalska I: [IA-2 and anti-GAD antibodies in patients with newly diagnosed type 1 diabetes and their first degree relatives]. Przegl Lek. 2000;57(3):143-6. |
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| 11679444 | Savola K, Laara E, Vahasalo P, Kulmala P, Akerblom HK, Knip M: Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study. Diabetes. 2001 Nov;50(11):2625-32. To study the dynamics of disease-associated humoral immune responses, we analyzed autoantibodies to the IA-2 protein (IA-2A), glutamic acid decarboxylase (GADA), and insulin (IAA) and also islet cell antibodies (ICA) in a population-based, prospective, representative series of 710 siblings (<20 years of age) of children with type 1 diabetes. |
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| 14679084 | Matsunaga S, Maruyama T, Yamada S, Motohashi Y, Shigihara T, Shimada A, Saruta T: Nicotinamide adenine dinucleotide phosphate oxidase oxidase) P22 Phox C242T gene polymorphism in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov;1005:324-7. In addition, we allocated the diabetic patients to the following three groups: (1) acute-onset type 1 diabetes with at least one autoantibody (GADA, IA-2, IAA); (2) acute-onset type 1 diabetes without autoantibodies; and (3) slow-onset type 1 diabetes with autoantibody. |
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| 15895384 | Franke B, Galloway TS, Wilkin TJ: Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies. Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):395-415. The major target antigens are islet-cell antigen, glutamic acid decarboxylase (GAD), protein-tyrosine phosphatase-2 (IA-2) and insulin. |
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| 11033022 | Woo W, LaGasse JM, Zhou Z, Patel R, Palmer JP, Campus H, Hagopian WA: A novel high-throughput method for accurate, rapid, and economical measurement of multiple type 1 diabetes autoantibodies. J Immunol Methods. 2000 Oct 20;244(1-2):91-103. The format worked well using diverse antigens such as 35S-met-GAD65, 35S-met-ICA512/IA2, 35S-met-Phogrin, and 125I-insulin, and could be used for simultaneous screening of reactivity to both GAD65 and ICA512/IA2 in the same well. |
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| 9137905 | Ongagna JC, Levy-Marchal C: Sensitivity at diagnosis of combined beta-cell autoantibodies in insulin-dependent diabetic children. Diabetes Metab. 1997 Apr;23(2):155-60. One hundred and thirty-eight sera were tested for islet cell antibodies (ICA), insulin autoantibodies (IAA) and antibodies against glutamic acid decarboxylase (GAD-Ab) and phosphatase (IA2-Ab). |
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| 11600541 | Kimpimaki T, Kupila A, Hamalainen AM, Kukko M, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M: The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab. 2001 Oct;86(10):4782-8. If an infant seroconverted to ICA positivity, all his/her samples were also analyzed for insulin autoantibodies (IAA), antibodies to the 65-kDa isoform of glutamic acid decarboxylase, and antibodies to the protein tyrosine phosphatase-related IA-2 molecule. |
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| 10023861 | Kretowski A, Szelachowska M, Pietruczuk M, Kinalska I: CD23 antigen expression on B lymphocytes and soluble CD23 levels in peripheral blood of high-risk type 1 diabetes subjects. Scand J Immunol. 1999 Jan;49(1):78-81. The study was carried out in 28 first-degree relatives of type 1 diabetes patients (versus a control group of 28 age- and sex-matched healthy volunteers) using antibodies against different B-cell antigens: ICA, GADA, IAA, IA-2. |
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| 12369720 | Mansson L, Torn C, Landin-Olsson M: Islet cell antibodies represent autoimmune response against several antigens. J Autoimmun. 1999 Sep;13(2):257-65. The serum samples were incubated with the specific antigen (GAD65, IA-2 or insulin) and the ICA analysis and the corresponding immunoprecipitation assay were performed before and after the absorption. |
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| 10909610 | Lazar D, Weintrob N, Abramov N, Assa S, Bloch K, Ofan R, Ben-Zaken H, Vardi P: [Islet autoantibody assays in type I diabetes: superiority of passage from use of ICA to traditional tests]. Harefuah. 1998 May 1;134(9):678-81 We examined the value of combined biochemically-based serological assays, such as autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and ICA512 (ICA512A) to replace the traditional ICA assay. |
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| 14988284 | Kukko M, Virtanen SM, Toivonen A, Simell S, Korhonen S, Ilonen J, Simel O, Knip M: Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country. Diabetes Care. 2004 Mar;27(3):676-81. If the child developed ICA, all samples were also analyzed for insulin autoantibodies (IAA), GAD65 antibodies (GADA), and antibodies to the IA-2 molecule (IA-2A). |
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| 11423499 | Winnock F, Christie MR, Batstra MR, Aanstoot HJ, Weets I, Decochez K, Jopart P, Nicolaij D, Gorus FK: Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre) type 1 diabetes: association with IA-2 and islet cell autoantibodies. Diabetes Care. 2001 Jul;24(7):1181-6. |
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| 14679074 | Holmberg H, Vaarala O, Falth-Magnusson K, Ludvigsson J: Induction of diabetes-related autoantibodies below cutoff for "positivity" in young nondiabetic children. Ann N Y Acad Sci. 2003 Nov;1005:269-74. Our results suggest that the mechanisms of beta cell tolerance to GAD and IA-2 differ in healthy children. |
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| 14679035 | Yu L, Eisenbarth G, Bonifacio E, Thomas J, Atkinson M, Wasserfall C: The second murine autoantibody workshop: remarkable interlaboratory concordance for radiobinding assays to identify insulin autoantibodies in nonobese diabetic mice. Ann N Y Acad Sci. 2003 Nov;1005:1-12. However, subsequent absorption studies performed after the workshop (presented at the IDS meeting) brought into question whether ELISA assays for IAA do, in reality, detect anti-insulin immunities and whether assays for GAD and IA-2 autoantibodies distinguish diabetes-prone from nondiabetes-prone mice. |
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| 10064098 | Lindberg B, Ivarsson SA, Landin-Olsson M, Sundkvist G, Svanberg L, Lernmark A: Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia. 1999 Feb;42(2):181-7. Cord blood sera from 81 children who developed Type I diabetes between 10 months and 14.9 years of age were tested for glutamic acid decarboxylase autoantibodies (GAD65Ab), islet cell antigen 512 autoantibodies (ICA512Ab), insulin autoantibodies (IAA) all by quantitative radioligand binding assays and islet cell autoantibodies (ICA) by indirect immunofluorescence. |
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| 9568692 | Dittler J, Seidel D, Schenker M, Ziegler AG: GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives. Diabetes. 1998 Apr;47(4):592-7. A new radiobinding assay for the simultaneous detection of antibodies to GAD and the phosphatase IA2 has been recently described in patients with newly diagnosed type 1 diabetes. |
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| 12672406 | Koczwara K, Schenker M, Schmid S, Kredel K, Ziegler AG, Bonifacio E: Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse. Clin Immunol. 2003 Feb;106(2):155-62. To address this, antibody titer and subclass to insulin, glutamic acid decarboxylase (GAD) 65, IA-2, and IA-2beta proteins were measured by radiobinding assays in untreated or immunized female nonobese diabetic mice. |
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| 18176860 | Taplin CE, Barker JM: Autoantibodies in type 1 diabetes. Autoimmunity. 2008 Feb;41(1):11-8. Subsequently, antibodies to insulin (IAA), glutamic acid decarboxylase (GAA or GAD) and protein tyrosine phosphatase (IA2 or ICA512) have all been defined. |
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| 15699499 | Kawasaki E, Eguchi K: Is Type 1 diabetes in the Japanese population the same as among Caucasians?. Ann N Y Acad Sci. 2004 Dec;1037:96-103. However, the prevalences of anti-islet autoantibodies in patients with Japanese type 1 diabetes are 60-70% for GAD autoantibodies, 45-50% for insulin autoantibodies (IAA), and 60-65% for IA-2 autoantibodies at disease onset, which are similar to those reported in Caucasian patients. |
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| 11872662 | Kupila A, Keskinen P, Simell T, Erkkila S, Arvilommi P, Korhonen S, Kimpimaki T, Sjoroos M, Ronkainen M, Ilonen J, Knip M, Simell O: Genetic risk determines the emergence of diabetes-associated autoantibodies in young children. Diabetes. 2002 Mar;51(3):646-51. Islet cell autoantibodies (ICAs) and, in the 137 children with ICAs, insulin autoantibodies (IAAs), GAD65 autoantibodies (GADAs), and IA-2 protein autoantibodies (IA-2As) were measured. |
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| 11994372 | Schlosser M, Strebelow M, Wassmuth R, Arnold ML, Breunig I, Rjasanowski I, Ziegler B, Ziegler M: The Karlsburg type 1 diabetes risk study of a normal schoolchild population: association of beta-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individuals. J Clin Endocrinol Metab. 2002 May;87(5):2254-61. AAbs against glutamic acid decarboxylase (GADA), phosphatase IA-2 (IA-2A), and/or insulin (IAA) were detected by (125) I-antigen binding and islet cell antibodies (ICA) immunohistochemically in 181 (2.86%) schoolchildren. |
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| 17512892 | Laadhar L, Gassara A, Mahfoudh N, Ben Hadj hmida Y, Kamoun T, Ben Ayed M, Rekik N, Mahfoudh A, Rebai A, Makni H, Abid M, Hachicha M, Masmoudi H: [Susceptibility markers in Tunisian first-degree relatives of patients with type 1 diabetes]. 750. Islet cell antibodies (ICA) were detected by immunofluorescence on monkey pancreas; decarboxylase (GADA), IA2 (IA2-A) and insulin (IAA) antibodies were measured by RIA. |
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| 12605834 | Aguilera E, Recasens M, Morinigo RA, Casamitjana R, Oriola J, Ercilla G, Conget I: [Clinical, metabolic, immunologic and genotypic characteristics in non-pediatric patients with type 1A diabetes mellitus. Med Clin. 2003 Feb 8;120(4):121-4. The presence of pancreatic autoantibodies, GAD, IA2 and IAA was evaluated. |
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| 12716742 | Bingley PJ, Bonifacio E, Mueller PW: Diabetes Antibody Standardization Program: first assay proficiency evaluation. Diabetes. 2003 May;52(5):1128-36. The aims of the first proficiency evaluation of the Diabetes Antibody Standardization Program (DASP) were to assess general implementation of assay methods and to evaluate the new World Health Organization (WHO) reference reagent for autoantibodies to GAD and IA-2. |
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| 11460579 | Seissler J, Hatziagelaki E, Scherbaum WA: Modern concepts for the prediction of type 1 diabetes. Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S304-16. The availability of recombinant antigens, most notably the enzyme glutamic acid decarboxylase (GAD) and the phosphatase-like molecule IA-2, made it possible to develop simple, sensitive and specific radioimmunoassays for the detection of autoantibodies on a large scale. |
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| 12132348 | Vavrinec J, Cinek O, Sumnik Z, Kolouskova S, Malcova H, Drevinek P, Snajderova M: [Prediction of type 1 diabetes mellitus in first degree Czech relatives of diabetic patients]. Vnitr Lek. 2002 Jun;48(6):483-9. Sera of all children were investigated for anti-GAD65, anti-IA2 and insulin antibodies using RIA methods. |
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| 9700342 | Colman PG, McNair P, Margetts H, Schmidli RS, Werther GA, Alford FP, Ward GM, Tait BD, Honeyman MC, Harrison LC: The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing. Med J Aust. 1998 Jul 20;169(2):81-4. MAIN OUTCOME MEASURES: Prevalence of islet cell antibodies (ICA) levels > or = 20 JDFu, insulin autoantibodies (IAA) levels > 100 nU/mL, and antibodies to glutamic acid decarboxylase (GADAb) and phosphatase IA2 (IA2Ab); change in beta cell function over time; and development of clinical diabetes. |
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| 10753042 | Colman PG, Steele C, Couper JJ, Beresford SJ, Powell T, Kewming K, Pollard A, Gellert S, Tait B, Honeyman M, Harrison LC: Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia. 2000 Feb;43(2):203-9. Human leukocyte antigen typing and assays for insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADAb) and phosphatase IA2 (IA2Ab) antibodies were done on cord blood, and venous blood was sampled every 6 months for IAA, GADAb and IA2Ab. |
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| 17130536 | Pozzilli P, Guglielmi C: Immunomodulation for the prevention of SPIDDM and LADA. Ann N Y Acad Sci. 2006 Oct;1079:90-8. When diagnosed in adults it is characterized by the presence of islet cell-related autoantibodies (ICA), in particular GAD and IA2 (less common) and very rarely insulin autoantibodies (IAA). |
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| 12087006 | Hummel M, Bonifacio E, Naserke HE, Ziegler AG: Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high-risk subjects. Diabetes Care. 2002 Jul;25(7):1111-6. Gliadin antibodies as well as the diabetes-related antibodies insulin autoantibody (IAA), GAD antibody (GADA), and tyrosin phosphatase IA2 antibody (IA-2A) were measured every 3 months; oral tolerance tests were performed every 6 months. |
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| 12831633 | Mlynarski W, Wyka K, Bodalska-LIpinska J, Andrzejewski W, Zmyslowska A, Bodalski J: [Prognostic value of humoral and metabolic markers as an evaluation of risk for developing type 1 diabetes]. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2003;9(1):17-22. The aim of this study was to define the prognostic value of type 1 diabetes antiislet humoral markers (ICA, anti-GAD, anti-IA2 and IAA) and to find out thresholds for insulin and C-peptide levels at which clinically overt type 1 diabetes develops. |
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| 9594623 | Yokota I, Shima K: [GAD antibody in IDDM] . Rinsho Byori. 1998 Apr;46(4):331-7. GAD is a key antigen for the development of autoimmunity against beta-cells and the production of GADAb precedes other autoantibodies such as IAA and ICA512/IA-2Ab prior to the clinical onset of IDDM. |
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| 14679108 | Kawasaki E, Abiru N, Ide A, Sun F, Fukushima T, Takahashi R, Kuwahara H, Fujita N, Kita A, Oshima K, Uotani S, Yamasaki H, Yamaguchi Y, Eguchi K: Epitope analysis of GAD65 autoantibodies in Japanese patients with autoimmune diabetes. Ann N Y Acad Sci. 2003 Nov;1005:440-8. The circulating autoantibodies to multiple islet autoantigens including GAD, insulin, and IA-2 are the important immunological features of type 1 diabetes. |
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| 9628241 | Breidert M, Temelkova-Kurktschiev T, Hanefeld M, Leonhardt W, Schmoeckel A, Seissler J: Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus. Exp Clin Endocrinol Diabetes. 1998;106(2):113-6. To evaluate the potential of autoimmune markers in identifying patients with slowly progressive IDDM in the prediabetic state, we screened a population of 151 patients aged 37-70 years with impaired glucose tolerance (IGT) for the presence of islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA), and antibodies to phosphatase IA-2 (IA-2A). |
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| 15508807 | Szepietowska B, Szelachowska M, Gorska M, Jakubczyk D, Kinalska I: [Chronic complications in adult patients with newly diagnosed diabetes mellitus in relation to the presence of humoral autoimmune markers against pancreatic islet cells]. Pol Arch Med Wewn. 2004 May;111(5):563-9. decarboxylase antibodies (anti-GAD), protein tyrosine phosphatase antibodies (anti-IA-2) and anti-insulin antibodies (IAA) titers were measured by RIA. |
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