Protein Information

Name PARP
Synonyms COL11A2; PARP; Collagen alpha 2(XI) chain; Collagen alpha 2(XI) chain precursor; Collagen type XI alpha 2; Collagen type XI alpha 2 isoform 1; DFNA13; DFNB53…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
14607278 Kim DS, Jeon SE, Park KC: Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal. 2004 Jan;16(1):81-8.


We further investigated the IAA/HRP-mediated apoptotic pathways, and found that IAA/HRP activates caspase-8 and caspase-9, leading to caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
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16460736 Kim DS, Jeon SE, Jeong YM, Kim SY, Kwon SB, Park KC: Hydrogen peroxide is a mediator of indole-3-acetic acid/horseradish peroxidase-induced apoptosis. FEBS Lett. 2006 Feb 20;580(5):1439-46. Epub 2006 Jan 31.


On further investigating the IAA/HRP-mediated apoptotic pathway, we found that the IAA/HRP reaction leads to caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage, which was also blocked by catalase.
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17142972 Kim DS, Kim SY, Jeong YM, Jeon SE, Kim MK, Kwon SB, Na JI, Park KC: Light-activated indole-3-acetic acid induces apoptosis in g361 human melanoma cells. Biol Pharm Bull. 2006 Dec;29(12):2404-9.


We further investigated IAAUVB-mediated apoptotic pathways, and found that IAAUVB causes caspase-8, Bid, caspase-3 activation, and poly (ADP-ribose) polymerase (PARP) cleavage.
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20225657 Jeong YM, Oh MH, Kim SY, Li H, Yun HY, Baek KJ, Kwon NS, Kim WY, Kim DS: Indole-3-acetic acid/horseradish peroxidase induces apoptosis in TCCSUP human urinary bladder carcinoma cells. Pharmazie. 2010 Feb;65(2):122-6.


We further investigated the IAA/HRP-mediated apoptotic pathways and showed that IAA/HRP induces caspase-8 and caspase-9 activation, which results in caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
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19301020 Kim SY, Kim MK, Kwon SB, Na JI, Park KC, Kim DS: Tumor apoptosis by indole-3-acetic acid/light in B16F10 melanoma-implanted nude mice. Arch Dermatol Res. 2009 Apr;301(4):319-22. Epub 2009 Mar 20.


In addition, the expressions of p53, Fas, and PARP were upregulated in the IAA/IPL-treated group than in untreated control, demonstrating that IAA/IPL treatment caused apoptosis in melanoma-implanted nude mice.
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12244574 Greco O, Dachs GU, Tozer GM, Kanthou C: Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy. J Cell Biochem. 2002;87(2):221-32.


In the present work, some of the molecular and morphological features of the cells treated with HRP/IAA gene therapy were analysed.
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