Protein Information

Name caspase (protein family or complex)
Synonyms caspase; caspases

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
11833936 Abdo MA, Richards A, Atiya N, Singh B, Parkinson S, Hisheh S, Dharmarajan AM: Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea. Reprod Fertil Dev. 2001;13(5-6):395-403.

7(0,0,0,7) Details
12244574 Greco O, Dachs GU, Tozer GM, Kanthou C: Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy. J Cell Biochem. 2002;87(2):221-32.

In the present work, some of the molecular and morphological features of the cells treated with HRP/IAA gene therapy were analysed.
Caspases appeared to be involved as effectors in HRP/IAA-mediated apoptosis, since treatment with a general caspase inhibitor decreased the fraction of cells with micronuclei (MN) by 30%, with fragmented DNA by 50%, and with condensed chromatin by 60%.
1(0,0,0,1) Details
15895673 Jacob T, Hingorani A, Ascher E: Role of apoptosis and proteolysis in the pathogenesis of iliac artery aneurysms. Vascular. 2005 Jan-Feb;13(1):34-42.


Apoptosis was detected by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine triphosphate nick end-labeling (TUNEL) assay and caspase activity.
1(0,0,0,1) Details