| Name | glutamic acid decarboxylase |
|---|---|
| Synonyms | 65 kDa glutamic acid decarboxylase; GAD 2; GAD 65; GAD2; GAD65; Glutamate decarboxylase 2; Glutamate decarboxylase 2 (pancreas); Glutamate decarboxylase 65 kDa isoform… |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18416318 | Primo ME, Niepomniszcze H, Poskus E, Sala MS, Guaita SS, Sica MP, Villalba A, Cardoso A, Bruno OD: Frequency of pancreatic beta-cell autoimmunity markers in patients with autoimmune thyroid disease. Medicina (B Aires). 2008;68(1):37-42. Screening for markers of pancreatic beta-cell autoimmunity was performed by radioligand binding assays (RBA) as follows: autoantibodies to glutamic acid decarboxylase (GADA) and proinsulin (PAA) were determined in all sera, whereas autoantibodies to protein tyrosine phosphatase (IA-2A) and insulin (IAA) were additionally measured in 200 sera randomly selected from the total collection. |
1(0,0,0,1) | Details |
| 10739334 | Lindberg B, Carlsson A, Ericsson UB, Kockum I, Lernmark A, Landin-Olsson M, Sundkvist G, Ivarsson SA: Prevalence of beta-cell and thyroid autoantibody positivity in schoolchildren during three-year follow-up. Autoimmunity. 1999;31(3):175-85. The prevalence of autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65Ab), insulin (IAA), islet cells (ICA), thyroid peroxidase (TPOAb) and thyroglobulin (TgAb), in relation to HLA-DR types, was assessed in 310 (HLA in 280) twelve-year-old children during three-year follow-up. |
1(0,0,0,1) | Details |
| 20061424 | Kawasaki E, Nakamura K, Kuriya G, Satoh T, Kuwahara H, Kobayashi M, Abiru N, Yamasaki H, Eguchi K: Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes. J Clin Endocrinol Metab. 2010 Feb;95(2):707-13. Epub 2010 Jan 8. Furthermore, GAD65 autoantibody-specific epitopes were also analyzed using GAD65/GAD67 chimeric constructs. |
1(0,0,0,1) | Details |
| 16325957 | Tobon GJ, Arango A, Abad V, Garcia J, Cuervo H, Velasquez A, Angel ID, Vega P, Abad A, Anaya JM: Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population. Diabetes Res Clin Pract. 2006 May;72(2):170-5. Epub 2005 Dec 1. Glutamic acid decarboxylase antibodies (GADA), phosphatase antibodies (IA-2A) and insulin antibodies (IAA) were examined by radioimmunoassay. |
1(0,0,0,1) | Details |
| 20337975 | Delli AJ, Lindblad B, Carlsson A, Forsander G, Ivarsson SA, Ludvigsson J, Marcus C, Lernmark A: Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies. Pediatr Diabetes. 2010 Mar 10. These groups were compared with respect to T1DM HLA markers and islet autoantibodies [glutamic acid decarboxylase autoantibodies (GAD65Ab), insulin autoantibodies (IAA), and islet antigen-2 autoantibodies (IA-2Ab)]. |
1(0,0,0,1) | Details |
| 11994372 | Schlosser M, Strebelow M, Wassmuth R, Arnold ML, Breunig I, Rjasanowski I, Ziegler B, Ziegler M: The Karlsburg type 1 diabetes risk study of a normal schoolchild population: association of beta-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individuals. J Clin Endocrinol Metab. 2002 May;87(5):2254-61. AAbs against glutamic acid decarboxylase (GADA), phosphatase IA-2 (IA-2A), and/or insulin (IAA) were detected by (125) I-antigen binding and islet cell antibodies (ICA) immunohistochemically in 181 (2.86%) schoolchildren. |
1(0,0,0,1) | Details |
| 9790518 | Leinonen JS, Alho H, Harmoinen A, Lehtimaki T, Knip M: Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM. Free Radic Res. 1998 Aug;29(2):159-64. Twenty-two subjects tested positive for one or more IDDM-associated autoantibodies and 9 subjects had at least two of the three antibodies tested (antibodies against islet cells, ICA; glutamic acid decarboxylase, GADA; insulin, IAA). |
1(0,0,0,1) | Details |
| 16280641 | Aly T, Devendra D, Eisenbarth GS: Immunotherapeutic approaches to prevent, ameliorate, and cure type 1 diabetes. Am J Ther. 2005 Nov-Dec;12(6):481-90. Insulin, glutamic acid decarboxylase, and insulinoma associated-2 autoantibodies (IAA, GAD65, and IA-2) are the autoantibodies that have been associated most clearly with the development of T1D. |
1(0,0,0,1) | Details |
| 9152613 | Maruyama T, Kasuga A, Ozawa Y, Nagata A, Abiko F, Suzuki Y, Saruta T: Glutamic acid decarboxylase65 (GAD65) antibodies and insulin auto-antibodies in Japanese patients with non-insulin-dependent diabetes mellitus. Endocr J. 1997 Feb;44(1):43-51. |
6(0,0,0,6) | Details |
| 12364437 | Kimpimaki T, Kulmala P, Savola K, Kupila A, Korhonen S, Simell T, Ilonen J, Simell O, Knip M: Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population. J Clin Endocrinol Metab. 2002 Oct;87(10):4572-9. The aim of this study was to evaluate the frequency and predictive value of diabetes-associated autoantibodies, such as islet cell antibodies (ICA) and autoantibodies to insulin (IAA), GAD65 (GADA), and the IA-2 molecule (IA-2A) in genetically susceptible children from the general population during the first 2 yr of life. |
1(0,0,0,1) | Details |
| 12519837 | Krischer JP, Cuthbertson DD, Yu L, Orban T, Maclaren N, Jackson R, Winter WE, Schatz DA, Palmer JP, Eisenbarth GS: Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab. 2003 Jan;88(1):103-8. The objective of this study was to determine the extent to which different screening strategies could identify a population of nondiabetic relatives of a proband with type 1 diabetes who had two or more immunologic markers from the group consisting of islet cell antibodies (ICA), micro insulin autoantibodies (MIAA), GAD65 autoantibodies (GAA), and ICA512 autoantibodies (ICA512AA). |
1(0,0,0,1) | Details |
| 17578823 | Erten G, Gurol AO, Deniz G, Satman I, Yilmaz MT: Organ specific autoantibodies in preclinical and early clinical type 1 diabetes in Turkey. Ups J Med Sci. 2007;112(2):231-43. Type 1 diabetes mellitus (T1D) patients (G1; n=73) and first degree relatives with islet cell antibody (ICA) values of > or=10 JDF u twice or > or=20 JDF u one and loss of FPIR (G2; n=18) were screened for two other autoantibodies, anti-glutamic acid decarboxylase (GADA) and insulin autoantibodies (IAA), and for other organ-specific autoantibodies, anti-gastric parietal cell (anti-PCA) and anti-thyroid peroxidase (anti-TPO) as well. |
1(0,0,0,1) | Details |
| 15895384 | Franke B, Galloway TS, Wilkin TJ: Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies. Diabetes Metab Res Rev. 2005 Sep-Oct;21(5):395-415. The major target antigens are islet-cell antigen, glutamic acid decarboxylase (GAD), protein-tyrosine phosphatase-2 (IA-2) and insulin. |
1(0,0,0,1) | Details |
| 11192752 | Cinek O, Pechova M, Kolouskova S, Horka I, Sedlakova P, Sumnik Z, Snajderova M, Vavrinec J: [Autoantibodies to GAD65, IA2 and insulin in Czech children with type 1 diabetes]. Cas Lek Cesk. 2000 Sep 27;139(19):599-603. |
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| 12369720 | Mansson L, Torn C, Landin-Olsson M: Islet cell antibodies represent autoimmune response against several antigens. Autoimmunity. 2003 Jun;36(4):227-31. To study the antigens involved in the islet cell antibody (ICA) reaction we selected 30 patient serum samples (ten in each group) positive for ICA and one other additional autoantibody, such as glutamic acid decarboxylase antibodies (GADA), thyrosine phosphatase antibodies (IA-2A) or insulin autoantibodies (IAA). |
4(0,0,0,4) | Details |
| 12132348 | Vavrinec J, Cinek O, Sumnik Z, Kolouskova S, Malcova H, Drevinek P, Snajderova M: [Prediction of type 1 diabetes mellitus in first degree Czech relatives of diabetic patients]. Vnitr Lek. 2002 Jun;48(6):483-9. Sera of all children were investigated for anti-GAD65, anti-IA2 and insulin antibodies using RIA methods. |
3(0,0,0,3) | Details |
| 17130560 | Gupta M, Graham J, McNeeny B, Zarghami M, Landin-Olsson M, Hagopian WA, Palmer J, Lernmark A, Sanjeevi CB: MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus. Ann N Y Acad Sci. 2006 Oct;1079:229-39. In type 1 diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. |
3(0,0,0,3) | Details |
| 14679044 | Schlosser M, Wassmuth R, Strebelow M, Rjasanowski I, Ziegler M: Multiple and high-titer single autoantibodies in schoolchildren reflecting the genetic predisposition for type 1 diabetes. Ann N Y Acad Sci. 2003 Nov;1005:98-108. AAbs against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and insulin (IAA) were determined by (125) I-antigen binding, and islet cell cytoplasmic antibodies (ICAs) immunohistochemically. |
1(0,0,0,1) | Details |
| 12175117 | Alpigiani MG, Cerboni M, Bertini I, d'Annunzio G, Haupt R, Iester A, Lorini R: Endocrine autoimmunity in young patients with juvenile chronic arthritis. . Clin Exp Rheumatol. 2002 Jul-Aug;20(4):565-8. T1DM screening included determination of anti-glutamic acid decarboxylase (GADA), anti-insulin (IAA), anti- phosphatase-like protein (IA-2A) and anti-islet cell (ICA) autoantibodies. |
1(0,0,0,1) | Details |
| 11460579 | Seissler J, Hatziagelaki E, Scherbaum WA: Modern concepts for the prediction of type 1 diabetes. Exp Clin Endocrinol Diabetes. 2001;109 Suppl 2:S304-16. The availability of recombinant antigens, most notably the enzyme glutamic acid decarboxylase (GAD) and the phosphatase-like molecule IA-2, made it possible to develop simple, sensitive and specific radioimmunoassays for the detection of autoantibodies on a large scale. |
1(0,0,0,1) | Details |
| 12930364 | Viskari H, Paronen J, Keskinen P, Simell S, Zawilinska B, Zgorniak-Nowosielska I, Korhonen S, Ilonen J, Simell O, Haapala AM, Knip M, Hyoty H: Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome. Clin Exp Immunol. 2003 Sep;133(3):378-83. The incidence of clinical diabetes, thyroid disease, coeliac disease and related antibodies (islet cell antibodies, ICA; insulin autoantibodies, IAA; antibodies to the phosphatase related IA-2 molecule, IA-2 A and glutamic acid decarboxylase, GADA; thyroid peroxidase, TPO; tissue transglutaminase, TTGA; and gliadin, AGA) and HLA risk genotypes were analysed in 37 subjects affected by or exposed to rubella during fetal life (mean age 22.5 years). |
1(0,0,0,1) | Details |
| 11683397 | Valdez SN, Sica MP, Labovsky V, Iacono RF, Cardoso AL, Krochik AG, Mazza CS, Ermacora MR, Cedola N, Poskus E: Combined measurement of diabetes mellitus immunological markers: an assessment of its benefits in adult-onset patients. Autoimmunity. 2001;33(4):227-36. The convenience of combining the measurement of antibodies to glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and autoantibodies to insulin (IAA) in diabetic patients was assessed. |
1(0,0,0,1) | Details |
| 9137905 | Ongagna JC, Levy-Marchal C: Sensitivity at diagnosis of combined beta-cell autoantibodies in insulin-dependent diabetic children. Diabetes Metab. 1997 Apr;23(2):155-60. One hundred and thirty-eight sera were tested for islet cell antibodies (ICA), insulin autoantibodies (IAA) and antibodies against glutamic acid decarboxylase (GAD-Ab) and phosphatase (IA2-Ab). |
1(0,0,0,1) | Details |
| 19741189 | Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R, Yu L, Palmer JP, Schatz D, Eisenbarth G: Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care. 2009 Dec;32(12):2269-74. Epub 2009 Sep 9. Autoantibodies to GAD 65 (GAD65), insulinoma-associated antigen-2 (ICA512), and insulin (micro-IAA [mIAA]) were also measured. |
3(0,0,0,3) | Details |
| 10330299 | Maclaren N, Lan M, Coutant R, Schatz D, Silverstein J, Muir A, Clare-Salzer M, She JX, Malone J, Crockett S, Schwartz S, Quattrin T, DeSilva M, Vander Vegt P, Notkins A, Krischer J: Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives. J Autoimmun. 1999 Jun;12(4):279-87. |
2(0,0,0,2) | Details |
| 11134089 | Gylling M, Tuomi T, Bjorses P, Kontiainen S, Partanen J, Christie MR, Knip M, Perheentupa J, Miettinen A: ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2000 Dec;85(12):4434-40. The patients are at high risk of developing insulin-dependent (type 1) diabetes, but the positive predictive value of GAD65 or islet cell antibodies for type 1 diabetes is only 27%. |
1(0,0,0,1) | Details |
| 11510200 | Perez-Bravo F, Riesco V, Albala C, Oyarzun A, Santos JL, Carrasco E: [Auto-antibody profile and breast feeding in type 1 diabetic patients] . Rev Med Chil. 2001 Jun;129(6):611-9. BACKGROUND: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti- phosphatase (IA2) can be present in patients with type I diabetes. |
1(0,0,0,1) | Details |
| 10527392 | Morano S, Tiberti C, Cristina G, Sensi M, Cipriani R, Guidobaldi L, Torresi P, Medici F, Anastasi E, Di Mario U: Autoimmune markers and neurological complications in non-insulin-dependent diabetes mellitus. Hum Immunol. 1999 Sep;60(9):848-54. Autoimmunity was investigated by evaluating glutamic acid decarboxylase (GAD-Ab), insulin (IAA), and GT1b gangliosides, pancreatic islet cell (IC-A) and anti-nervous-tissue autoantibody presence. |
1(0,0,0,1) | Details |
| 15872335 | Kukko M, Kimpimaki T, Korhonen S, Kupila A, Simell S, Veijola R, Simell T, Ilonen J, Simell O, Knip M: Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population. J Clin Endocrinol Metab. 2005 May;90(5):2712-7. Epub 2005 Feb 15. This study characterized the dynamics of islet cell antibodies (ICA), insulin antibodies (IAA), glutamic acid decarboxylase antibodies (GADA), and IA-2 antibodies (IA-2A) in 1006 children recruited from the general population due to human leukocyte antigen (HLA) DQB1-conferred risk for type 1 diabetes (T1D). |
1(0,0,0,1) | Details |
| 16100734 | Kukko M, Toivonen A, Kupila A, Korhonen S, Keskinen P, Veijola R, Virtanen SM, Ilonen J, Simell O, Knip M: Familial clustering of beta-cell autoimmunity in initially non-diabetic children. Diabetes Metab Res Rev. 2006 Jan-Feb;22(1):53-8. When a child tested positive for ICA, all his/her previous or subsequent samples that were available were also tested for insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA) and antibodies to the IA-2 protein (IA-2A). |
1(0,0,0,1) | Details |
| 10064098 | Lindberg B, Ivarsson SA, Landin-Olsson M, Sundkvist G, Svanberg L, Lernmark A: Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia. 1999 Feb;42(2):181-7. Cord blood sera from 81 children who developed Type I diabetes between 10 months and 14.9 years of age were tested for glutamic acid decarboxylase autoantibodies (GAD65Ab), islet cell antigen 512 autoantibodies (ICA512Ab), insulin autoantibodies (IAA) all by quantitative radioligand binding assays and islet cell autoantibodies (ICA) by indirect immunofluorescence. |
2(0,0,0,2) | Details |
| 9700342 | Colman PG, McNair P, Margetts H, Schmidli RS, Werther GA, Alford FP, Ward GM, Tait BD, Honeyman MC, Harrison LC: The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing. Med J Aust. 1998 Jul 20;169(2):81-4. MAIN OUTCOME MEASURES: Prevalence of islet cell antibodies (ICA) levels > or = 20 JDFu, insulin autoantibodies (IAA) levels > 100 nU/mL, and antibodies to glutamic acid decarboxylase (GADAb) and phosphatase IA2 (IA2Ab); change in beta cell function over time; and development of clinical diabetes. |
2(0,0,0,2) | Details |
| 11679444 | Savola K, Laara E, Vahasalo P, Kulmala P, Akerblom HK, Knip M: Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study. Diabetes. 2001 Nov;50(11):2625-32. To study the dynamics of disease-associated humoral immune responses, we analyzed autoantibodies to the IA-2 protein (IA-2A), glutamic acid decarboxylase (GADA), and insulin (IAA) and also islet cell antibodies (ICA) in a population-based, prospective, representative series of 710 siblings (<20 years of age) of children with type 1 diabetes. |
1(0,0,0,1) | Details |
| 11600541 | Kimpimaki T, Kupila A, Hamalainen AM, Kukko M, Kulmala P, Savola K, Simell T, Keskinen P, Ilonen J, Simell O, Knip M: The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab. 2001 Oct;86(10):4782-8. If an infant seroconverted to ICA positivity, all his/her samples were also analyzed for insulin autoantibodies (IAA), antibodies to the 65-kDa isoform of glutamic acid decarboxylase, and antibodies to the protein tyrosine phosphatase-related IA-2 molecule. |
1(0,0,0,1) | Details |
| 10209508 | Sabbah E, Savola K, Kulmala P, Reijonen H, Veijola R, Vahasalo P, Karjalainen J, Ilonen J, Akerblom HK, Knip M: Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Clin Exp Immunol. 1999 Apr;116(1):78-83. The possible relation between HLA-DQ genotypes and both frequencies and levels of autoantibodies associated with IDDM was assessed by examining HLA-DQB1 alleles and antibodies to islet cells (ICA), insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase-related IA-2 molecule (IA-2A) in 631 newly diagnosed diabetic children under the age of 15 years. |
1(0,0,0,1) | Details |
| 11474874 | Krochik AG, Mazza CS, Valdez SN, Stumpo RR, Papouchado ML, Iacono RF, Cardoso Landaburu AC, Sica MP, Ozuna B, Poskus E: Immunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population. Medicina (B Aires). 2001;61(3):279-83. The objective was to evaluate the prevalence and association of several markers (islet cell antibodies: ICA, insulin autoantibodies: IAA, glutamic acid decarboxylase antibodies: GADA and ICA512 antibodies: ICA512A) along with HLA DQB1 genotype in type 1 diabetes mellitus of recent onset, including siblings and individuals without any history of this disease, in an Argentine population. |
1(0,0,0,1) | Details |
| 18588707 | Murgia C, Orru M, Portoghese E, Garau N, Zedda P, Berria R, Motzo C, Sulis S, Murenu M, Paoletti AM, Melis GB: Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Reprod Biol Endocrinol. 2008 Jun 29;6:24. METHODS: We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity. |
2(0,0,0,2) | Details |
| 9594623 | Yokota I, Shima K: [GAD antibody in IDDM] . Rinsho Byori. 1998 Apr;46(4):331-7. Glutamic acid decarboxylase (GAD) catalyzes the formation of which is a major transmitter in the central nervous system. |
2(0,0,0,2) | Details |
| 14679108 | Kawasaki E, Abiru N, Ide A, Sun F, Fukushima T, Takahashi R, Kuwahara H, Fujita N, Kita A, Oshima K, Uotani S, Yamasaki H, Yamaguchi Y, Eguchi K: Epitope analysis of GAD65 autoantibodies in Japanese patients with autoimmune diabetes. Ann N Y Acad Sci. 2003 Nov;1005:440-8. |
2(0,0,0,2) | Details |
| 12575550 | Mao W, Ye W, Liu Q: [Preliminary study on relationship between TCM syndrome-type and insulin resistance in coronary heart disease]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Sep;21(9):657-9. The fasting blood (FBG), fasting blood insulin (Ins), insulin antibody (IAA), islet cell antibody (ICA), glutamic acid decarboxylase antibody (GAD-Ab) and related blood lipid parameters in patients were determined and insulin sensitive index (ISI) was calculated simultaneously. |
1(0,0,0,1) | Details |
| 18725905 | Gerhardt CM, Klingensmith GJ: New-onset diabetes in an obese adolescent: diagnostic dilemmas. Nat Clin Pract Endocrinol Metab. 2008 Oct;4(10):578-83. Epub 2008 Aug 26. Subsequently, measurements of fasting C-peptide and immunoassays for insulin autoantibodies (IAA), islet-cell autoantibodies (ICA-512) and glutamic acid decarboxylase autoantibodies (GAD-65) were performed. |
1(0,0,0,1) | Details |
| 10909610 | Lazar D, Weintrob N, Abramov N, Assa S, Bloch K, Ofan R, Ben-Zaken H, Vardi P: [Islet autoantibody assays in type I diabetes: superiority of passage from use of ICA to traditional tests]. Harefuah. 1998 May 1;134(9):678-81 We examined the value of combined biochemically-based serological assays, such as autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and ICA512 (ICA512A) to replace the traditional ICA assay. |
1(0,0,0,1) | Details |
| 11353881 | Monge L, Pinach S, Caramellino L, Bertero MT, Dall'omo A, Carta Q: The possible role of autoimmunity in the pathogenesis of diabetes in B-thalassemia major. Diabetes Metab. 2001 Apr;27(2 Pt 1):149-54. MATERIAL AND METHODS: To evaluate the activation of an autoimmune response, individuals were tested for islet cell antibodies (ICA), glutamic acid decarboxylase (GAD) autoantibodies, insulin autoantibodies (IAA) and serum anti-nuclear antibodies (ANA). |
1(0,0,0,1) | Details |
| 11416235 | Bilbao JR, Rica I, Vazquez JA, Busturia MA, Castano L: Influence of sex and age at onset on autoantibodies against insulin, GAD65 and IA2 in recent onset type 1 diabetic patients. Horm Res. 2000;54(4):181-5. |
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| 12482194 | Rolandsson O, Haney MF, Hagg E, Biber B, Lernmark A: Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?. Autoimmunity. 2002 Jul;35(4):261-4. Serum was analysed for the presence of the enzyme glutamic acid decarboxylase, isoform 65, (GAD65) and autoantibodies against glutamic acid decarboxylase, isoform 65 (GAD65A), isoform 67 (GAD67A), insulinoma antigen 2 (IA-2) and insulin (IAA). |
2(0,0,0,2) | Details |
| 10909282 | Kretowski A, Kowalska I, Peczynska J, Urban M, Kinalska I: [IA-2 and anti-GAD antibodies in patients with newly diagnosed type 1 diabetes and their first degree relatives]. Przegl Lek. 2000;57(3):143-6. The aim of the study was the estimation of the prevalence and titre of the antibodies directed against protein tyrosine phosphatase-2 (IA-2) and glutamic acid decarboxylase (GAD) in patients with newly diagnosed diabetes type 1 and their first degree relatives. |
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| 18178035 | Fakhfakh R, Haddouk S, Hadj Hamida YB, Kamoun T, Ayed MB, Hachicha M, Masmoudi H: Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes. Pathol Biol. 2008 May;56(3):130-2. Epub 2008 Jan 4. We analyzed 86 children with newly diagnosed type 1 diabetes for antibodies to islet cells (ICA), glutamic acid decarboxylase (GADA), second-islet antigen (IA-2A), and insulin (IAA) in order to evaluate the prevalence of immune-mediated type 1 diabetes, as well as to recognize which autoantibody combination is more frequently associated with the disease. |
1(0,0,0,1) | Details |
| 9435304 | Kulmala P, Savola K, Petersen JS, Vahasalo P, Karjalainen J, Lopponen T, Dyrberg T, Akerblom HK, Knip M: Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. J Clin Invest. 1998 Jan 15;101(2):327-36. An unselected population of 755 siblings of children with insulin-dependent diabetes mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies (ICA), antibodies to the IA-2 protein (IA-2A), antibodies to the 65-kD isoform of glutamic acid decarboxylase (GADA), insulin autoantibodies (IAA), and combinations of these markers. |
1(0,0,0,1) | Details |
| 16890898 | Wasserfall CH, Atkinson MA: Autoantibody markers for the diagnosis and prediction of type 1 diabetes. Int J Exp Diabetes Res. 2001;2(2):85-90. While autoantibodies to more than two dozen autoantigens have been associated with this disease, a majority of interest has been directed at four autoantibodies; islet cell cytoplasmic (ICA), insulin (IAA), glutamic acid decarboxylase (GADA), and IA2/ICA512 autoantigen (IA2A). |
1(0,0,0,1) | Details |
| 15016223 | Hathout EH, Sharkey J, Racine M, Thomas W, Nahab F, El-Shahawy M, Mace JW: Diabetic autoimmunity in infants and pre-schoolers with type 1 diabetes. Pediatr Diabetes. 2000 Sep;1(3):131-4. To determine the prevalence of diabetes autoimmune markers, ICA512, GAD65 and insulin autoantibodies (IAA) antibodies were measured. |
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| 11033022 | Woo W, LaGasse JM, Zhou Z, Patel R, Palmer JP, Campus H, Hagopian WA: A novel high-throughput method for accurate, rapid, and economical measurement of multiple type 1 diabetes autoantibodies. J Immunol Methods. 2000 Oct 20;244(1-2):91-103. The format worked well using diverse antigens such as 35S-met-GAD65, 35S-met-ICA512/IA2, 35S-met-Phogrin, and 125I-insulin, and could be used for simultaneous screening of reactivity to both GAD65 and ICA512/IA2 in the same well. |
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| 16442659 | Holmberg H, Vaarala O, Sadauskaite-Kuehne V, Ilonen J, Padaiga Z, Ludvigsson J: Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes. Diabetes Res Clin Pract. 2006 Jun;72(3):308-14. Epub 2006 Jan 26. |
2(0,0,0,2) | Details |
| 10047433 | Kasuga A, Maruyama T, Nakamoto S, Ozawa Y, Suzuki Y, Saruta T: High-titer autoantibodies against glutamic acid decarboxylase plus autoantibodies against insulin and IA-2 predicts insulin requirement in adult diabetic patients. J Autoimmun. 1999 Mar;12(2):131-5. |
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| 14988284 | Kukko M, Virtanen SM, Toivonen A, Simell S, Korhonen S, Ilonen J, Simel O, Knip M: Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country. Diabetes Care. 2004 Mar;27(3):676-81. If the child developed ICA, all samples were also analyzed for insulin autoantibodies (IAA), GAD65 antibodies (GADA), and antibodies to the IA-2 molecule (IA-2A). |
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| 18573919 | Makinen A, Harkonen T, Ilonen J, Knip M: Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes. Eur J Endocrinol. 2008 Jul;159(1):19-26. OBJECTIVE: To characterize the humoral immune response to islet antigen 2 (IA-2) in patients with newly diagnosed type 1 diabetes (T1D), we compared the profile of epitope- and isotype-specific IA-2 antibodies (IA-2A) between children with a humoral immune response restricted to IA-2 and children with a broad response including insulin autoantibodies (IAA) and antibodies to glutamic acid decarboxylase (GADA) in addition to IA-2A. |
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| 10612480 | Jaeger C, Hatziagelaki E, Stroedter A, Becker F, Scherer S, Petzoldt R, Federlin K, Bretzel RG: The Giessen-Bad Oeynhausen family study: improved prediction of type I diabetes in a low incidence population of relatives using combinations of islet autoantibodies in a dual step model. Exp Clin Endocrinol Diabetes. 1999;107(8):496-505. The first serum sample obtained at study entry was analyzed for ICA and antibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and anti-IA-2ic. |
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| 10078544 | Ziegler AG, Hummel M, Schenker M, Bonifacio E: Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes. 1999 Mar;48(3):460-8. Islet cell antibodies (ICAs) and autoantibodies to insulin (IAAs), glutamic acid decarboxylase, and IA-2 were measured at birth, 9 months, 2 years, and 5 years of age. |
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| 17919266 | Wang JP, Zhou ZG, Lin J, Huang G, Zhang C, Yang L, Yuan Y, Zhou HF, Zhou M, Hou C, Zhou WD, Peng H, Hagopian WA: Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relatives. Tissue Antigens. 2007 Nov;70(5):369-75. The objective of this study was to explore the relationship between islet autoantibodies of glutamic acid decarboxylase (GADA), islet antigen-2A (IA-2A), insulin autoantibody (IAA), and human leukocyte antigen (HLA)-DQ genotypes in type 1 diabetes (T1D) patients and their first-degree relatives (FDRs). |
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| 9433472 | Rulli M, Kuusisto A, Salo J, Kojola H, Simell O: Time-resolved fluorescence imaging in islet cell autoantibody quantitation. J Immunol Methods. 1997 Oct 27;208(2):169-79. Despite biochemical characterization of the major beta cell autoantigens insulin, glutamic acid decarboxylase and protein tyrosine phosphatase and development of the respective antibody assays, ICA has remained the standard in IDDM prediction. |
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| 9649953 | Yamada H, Uchigata Y, Kawasaki E, Matsuura N, Otani T, Sato A, Mutoh K, Kasahara T, Fukushima N, Koike A, Mizota M, Miura J, Kubo H, Yamaguchi A, Nagataki S, Omori Y, Iwamoto Y: Onset age-dependent variations of three islet specific autoantibodies in Japanese IDDM patients. Diabetes Res Clin Pract. 1998 Mar;39(3):211-7. To evaluate the onset age-related autoimmune profile at presentation in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD) autoantibody, islet cell antibody (ICA), and insulin autoantibody (IAA) were measured in 137 newly diagnosed Japanese IDDM patients with onset ages between 0-29 years. |
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| 9353155 | Van der Auwera BJ, Vandewalle CL, Schuit FC, Winnock F, De Leeuw IH, Van Imschoot S, Lamberigts G, Gorus FK: CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. Clin Exp Immunol. 1997 Oct;110(1):98-103. In a registry-based group of 525 recent-onset IDDM patients <40 years old we investigated the possible interactions of a CTLA-4 gene A-to-G transition polymorphism with age at clinical disease onset and with the presence or absence of established genetic (HLA-DQ, INS VNTR) and immune disease markers (autoantibodies against islet cell cytoplasm (ICA); insulin (IAA); decarboxylase (GAD65-Ab); IA-2 protein tyrosine phosphatase (IA-2-Ab)) determined within the first week of insulin treatment. |
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| 12099394 | da Silva ME, Porta G, Goldberg AC, Bittencourt PL, Fukui RT, Correia MR, Miura IK, Pugliese RS, Baggio VL, Cancado EL, Kalil J, Santos RF, Rochal DM, Wajchenberg BL, Ursich MJ, Rosenbloom AL: Diabetes mellitus-related autoantibodies in childhood autoimmune hepatitis. Diabetes. 2001 Nov;50(11):2451-8. RESEARCH DESIGN AND METHODS: Anti-islet cell antibodies (ICA), insulin autoantibodies (IAA), and anti-glutamic acid decarboxylase (GAD65) antibodies were assessed in 28 children (25 female) with AIH before and after 3-9 years of therapy with azathioprine and prednisone. |
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| 12557109 | Schilling I, Conrad K, Fussel M, Henker J: [Prevalence of type 1 diabetes-specific autoantibodies and of certain HLA patterns in celiac disease]. Dtsch Med Wochenschr. 2003 Jan 31;128(5):185-9. PATIENTS AND METHODS: 68 patients with CD (48 females and 20 males) were investigated by determining the diabetes-associated serological marker GADA (glutamic acid decarboxylase antibodies). 1A-2A (insulinoma-associated protein 2 antibodies), ICA (Islet cell antibodies) and IAA (insulin autoantibodies). |
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| 17461431 | Rajasalu T, Haller K, Salur L, Kisand K, Tillmann V, Schlosser M, Uibo R: Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes. Diabetes Metab Res Rev. 2007 Oct;23(7):567-71. |
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| 16614815 | Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J: Lymphoid phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia. 2006 Jun;49(6):1198-208. Epub 2006 Apr 14. SUBJECTS AND METHODS: A population-derived Finnish birth cohort with increased disease susceptibility conferred by HLA-DQB1 was monitored for the appearance of islet cell autoantibodies, and individuals found to be positive were tested for autoantibodies against insulin (IAA), glutamic acid decarboxylase and islet antigen-2 (n = 574; mean follow-up time 4.9 years). |
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| 12687930 | Szepietowska B, Szelachowska M, Gorska M, Stepien A, Kinalska I: [Clinical, biochemical and immunological characteristic of diabetes type I, LADA, diabetes type II, and MODY patients]. Pol Arch Med Wewn. 2002 Dec;108(6):1177-84. We measured basal and stimulated C-peptide (6 minutes after 1 mg i.v. glucagon) (ELISA) and antibodies titers to glutamic acid decarboxylase--antiGAD65, tyrosine phosphatase-like molecule--IA2 and insulin--IAA (RIA). |
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| 10821292 | Ostman J, Landin-Olsson M, Torn C, Palmer J, Lernmark A, Arnqvist H, Bjork E, Bolinder J, Blohme G, Eriksson J, Littorin B, Nystrom L, Schersten B, Sundkvist G, Wibell L: Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus--a nationwide study. Diabet Med. 2000 Apr;17(4):269-74. The study examined islet cell antibodies (ICA) by indirect immunofluorescence, and autoantibodies to glutamic acid decarboxylase (GADA), phosphatase-like antigen (IA-2A) and insulin (IAA) as well as C-peptide by radioimmunoassay. |
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| 19761530 | Brekke HK, Ludvigsson J: Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring-The ABIS study. Pediatr Diabetes. 2009 Sep 16. IA was defined as being positive (above the 95th percentile for healthy children) in two or more measurements of autoantibodies [glutamic acid decarboxylase (GADA); phosphatase (IA-2A), insulin autoantibodies (IAA)] analysed at the three time points or being diagnosed with type 1 diabetes during the 5-yr follow-up period. |
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| 11947969 | Soriguer-Escofet F, Esteva I, Rojo-Martinez G, Ruiz de Adana S, Catala M, Merelo MJ, Aguilar M, Tinahones F, Garcia-Almeida JM, Gomez-Zumaquero JM, Cuesta-Munoz AL, Ortego J, Freire JM: Prevalence of latent autoimmune diabetes of adults (LADA) in Southern Spain. Diabetes Res Clin Pract. 2002 Jun;56(3):213-20. Clinical data were obtained and a blood sample taken to measure autoantibodies (glutamic acid decarboxylase antibodies (GADAb), phosphatase antibodies (IA2Ab), and insulin antibodies (IAA)). |
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| 18176860 | Taplin CE, Barker JM: Autoantibodies in type 1 diabetes. Autoimmunity. 2008 Feb;41(1):11-8. Subsequently, antibodies to insulin (IAA), glutamic acid decarboxylase (GAA or GAD) and protein tyrosine phosphatase (IA2 or ICA512) have all been defined. |
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| 11872662 | Kupila A, Keskinen P, Simell T, Erkkila S, Arvilommi P, Korhonen S, Kimpimaki T, Sjoroos M, Ronkainen M, Ilonen J, Knip M, Simell O: Genetic risk determines the emergence of diabetes-associated autoantibodies in young children. Diabetes. 2002 Mar;51(3):646-51. Islet cell autoantibodies (ICAs) and, in the 137 children with ICAs, insulin autoantibodies (IAAs), GAD65 autoantibodies (GADAs), and IA-2 protein autoantibodies (IA-2As) were measured. |
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| 9179462 | Ludvigsson J, Hellstrom S: Autoantibodies in relation to residual insulin secretion in children with IDDM. Diabetes Res Clin Pract. 1997 Mar;35(2-3):81-9. To elucidate whether autoantibodies can be used to predict the intensity of autoimmune beta-cell destruction, we determined both C-peptide and autoantibodies (islet cell antibodies (ICA), insulin autoantibodies (IAA), islet cell surface antibodies (ICSA) and antibodies to glutamic acid decarboxylase (GADA)). |
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| 14747235 | Stanley HM, Norris JM, Barriga K, Hoffman M, Yu L, Miao D, Erlich HA, Eisenbarth GS, Rewers M: Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY). Diabetes Care. 2004 Feb;27(2):497-502. RESEARCH DESIGN AND METHODS: Cord blood sera from 1,118 subjects from the Diabetes Autoimmunity Study in the Young (DAISY) cohort, as well as their venous blood samples taken at follow-up clinic visits, were tested for GAD65 autoantibodies (GAAs), insulin autoantibodies (IAAs), and IA-2 autoantibodies (IA-2As). |
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| 15016155 | Borg H, Marcus C, Sjoblad S, Fernlund P, Sundkvist G: Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age. Pediatr Diabetes. 2002 Sep;3(3):149-54. OBJECTIVE: To relate IAA to islet antibodies (i.e., islet cell antibodies [ICA], and antibodies against two ICA-related islet antigens, glutamic acid decarboxylase 65 [GADA] and protein tyrosine phosphatase IA-2 [IA-2 A]) at diagnosis, and to endogenous beta-cell function at follow-up after diagnosis in diabetic children. |
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| 15826926 | Falorni A, Brozzetti A: Diabetes-related antibodies in adult diabetic patients. Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):119-33. Islet autoimmunity is made evident by the appearance of islet-cell antibodies directed against insulin (IAA), glutamic acid decarboxylase (GADA), protein tyrosine phosphatase IA-2 (IA-2Ab) and other autoantigens. |
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| 10753042 | Colman PG, Steele C, Couper JJ, Beresford SJ, Powell T, Kewming K, Pollard A, Gellert S, Tait B, Honeyman M, Harrison LC: Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia. 2000 Feb;43(2):203-9. Human leukocyte antigen typing and assays for insulin autoantibodies (IAA), glutamic acid decarboxylase antibodies (GADAb) and phosphatase IA2 (IA2Ab) antibodies were done on cord blood, and venous blood was sampled every 6 months for IAA, GADAb and IA2Ab. |
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| 11921417 | Korhonen S, Knip MM, Kulmala P, Savola K, Akerblom HK, Knip M: Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblings. Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):43-8. BACKGROUND: Islet cell antibodies (ICA) represent a heterogenous group of autoantibodies to diabetes-associated antigens, including glutamic acid decarboxylase (GAD) and the IA-2 protein. |
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| 18282420 | Xin Y, Zhao YQ, Zhao YX, Zhang LH: [The changes of serum interferon-inducible protein-10 levels in children with type 1 diabetes mellitus]. Zhonghua Er Ke Za Zhi. 2007 Nov;45(11):853-5. METHODS: Serum IP-10 levels were measured by ELISA in 50 children with T1DM and 30 healthy children, and the levels of autoantibodies [glutamic acid decarboxylase (GAD), isle tcell antibody (ICA), insulin autoantibody (IAA) and phosphatase (IA-2)] in diabetic children were measured as well. |
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| 12017227 | Umpaichitra V, Banerji MA, Castells S: Autoantibodies in children with type 2 diabetes mellitus. . J Pediatr Endocrinol Metab. 2002 Apr;15 Suppl 1:525-30. To evaluate the frequency of autoantibodies to glutamic acid decarboxylase (GAD), protein tyrosine phosphatase-like protein (IA-2), and insulin (IAA) in children with type 2 diabetes mellitus (DM), we studied 37 children and adolescents whose type 2 DM was defined by fasting and 90-min standard liquid meal-stimulated serum C-peptide levels of > 0.2 and > 0.5 nmol/l (0.7 and 1.5 ng/ml), respectively. |
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| 17217566 | Holmberg H, Wahlberg J, Vaarala O, Ludvigsson J: Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population. Br J Nutr. 2007 Jan;97(1):111-6. Autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tryosine phosphatase-like IA-2 (IA-2A) were measured by radiobinding assays. |
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| 10382585 | Strebelow M, Schlosser M, Ziegler B, Rjasanowski I, Ziegler M: Karlsburg Type I diabetes risk study of a general population: frequencies and interactions of the four major Type I diabetes-associated autoantibodies studied in 9419 schoolchildren. Diabetologia. 1999 Jun;42(6):661-70. METHODS: We took capillary serum from 9419 schoolchildren, aged 6-17 years, for testing of autoantibodies (AAbs) to glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA2A) and insulin (IAA) by 125I-antigen binding. |
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| 15832972 | Cosmescu A, Graur M, Zlei M, Matasaru S, Felea D, Petroaie A, Slanina AM, Barbacariu L, Momanu O: [The study of two immunological markers in patients with type-1 diabetes and in their first degree relatives]. Rev Med Chir Soc Med Nat Iasi. 2004 Jul-Sep;108(3):549-53. The aim of this preliminary study was to determine islet cell antibodies (ICA) and glutamic acid decarboxylase antibodies (GADA) in 28 diabetic children (12 of them having an evolutive disease of 1 year and 16 at the beginning of the diabetes) and to 47 of their first-degree relatives. |
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| 17143785 | Betterle C, Lazzarotto F, Fusari A, Zanchetta R, Benedini S, Pedini B, Moscon A, Presotto F: Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus over the age of 20 years. Acta Diabetol. 2006 Nov;43(3):79-83. Autoantibodies to islet-cells (ICA) were detected by indirect immunofluorescence, while those against glutamic acid decarboxylase (GADA), -phosphatase (IA2A) and insulin (IAA) were detected by radiobinding assays. |
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| 9628241 | Breidert M, Temelkova-Kurktschiev T, Hanefeld M, Leonhardt W, Schmoeckel A, Seissler J: Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus. Exp Clin Endocrinol Diabetes. 1998;106(2):113-6. To evaluate the potential of autoimmune markers in identifying patients with slowly progressive IDDM in the prediabetic state, we screened a population of 151 patients aged 37-70 years with impaired glucose tolerance (IGT) for the presence of islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA), and antibodies to phosphatase IA-2 (IA-2A). |
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| 12787001 | Battelino T, Ursic-Bratina N, Dolzan V, Stopar-Obreza M, Pozzilli P, Krzisnik C, Vidan-Jeras B: The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes. Eur J Immunogenet. 2003 Jun;30(3):223-7. The aim of the present study was to determine the frequencies of HLA-DRB-DQB deduced haplotypes associated with susceptibility and protection in Slovenian patients with established T1D, to evaluate the relationship between the HLA-DRB1-QBP-DQB1 haplotypes and the presence of insulin autoantibodies (IAA) and glutamic acid decarboxylase antibodies (GADA), and to access the possible impact of polymorphic QBP promoters on this relationship. |
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| 10657849 | Conroy SJ, Abdel-Wahab YH, Caraher EM, Byrne PM, Murphy E, Nolan J, Flatt PR, Newsholme P: Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients. J Endocrinol. 2000 Feb;164(2):139-47. The concentration of glutamic acid decarboxylase (GAD) autoantibodies was markedly increased in the sera of six out of nine newly diagnosed IDDM patients in this study, whereas insulin auto-antibodies (IAA) were detected in the sera of three of the nine patients and islet-cell antibodies (ICA) in the sera of five of them. |
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| 9878086 | Yamamoto AM, Deschamps I, Garchon HJ, Roussely H, Moreau N, Beaurain G, Robert JJ, Bach JF: Young age and HLA markers enhance the risk of progression to type 1 diabetes in antibody-positive siblings of diabetic children. J Autoimmun. 1998 Dec;11(6):643-50. We evaluated islet cell antibodies (ICA) by indirect immunofluorescence and autoantibodies to insulin (IAA), to the 65 kDa isoform of glutamic acid decarboxylase (GADA) and to the IA-2 protein (IA-2A) by radioligand assay in sequential serum samples. |
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| 11555830 | Juneja R, Hirsch IB, Naik RG, Brooks-Worrell BM, Greenbaum CJ, Palmer JP: Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1 (1/2) diabetes in patients presenting with type 2 diabetes. Metabolism. 2001 Sep;50(9):1008-13. We studied 125 patients, recently diagnosed clinically with type 2 diabetes for the presence of islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADAb), and IA-2a (IA-2Ab). |
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| 15016154 | Colman PG, McNair PD, Gellert S, Kewming K, Schmidli RS, Steele CE, Harrison LC: Development of autoantibodies to islet antigens during childhood: implications for preclinical type 1 diabetes screening. Pediatr Diabetes. 2002 Sep;3(3):144-8. Of 423 who were eligible, 350 consented to re-testing for ICA and IAA and antibodies to glutamic acid decarboxylase (GADAb) and phosphatase-like insulinoma antigen IA-2 (IA2Ab) at a mean age of 11.1 yr. |
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| 15699502 | Schlosser M, Strebelow M, Rjasanowski I, Kerner W, Wassmuth R, Ziegler M: Prevalence of diabetes-associated autoantibodies in schoolchildren: the Karlsburg Type 1 Diabetes Risk Study. Ann N Y Acad Sci. 2004 Dec;1037:114-7. This study attempts to assess the prevalence of diabetes-associated autoantibodies in a general population in the northeastern part of Germany, with emphasis on autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and insulin (IAA) by radioassays >/= 98th percentile, and AAbs binding on pancreatic sections (ICA) by immunofluorescence >/= 10 Juvenile Diabetes Foundation units. |
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| 9223390 | Komulainen J, Knip M, Lounamaa R, Vahasalo P, Karjalainen J, Sabbah E, Akerblom HK: Poor beta-cell function after the clinical manifestation of type 1 diabetes in children initially positive for islet cell specific autoantibodies. Diabet Med. 1997 Jul;14(7):532-7. Seven hundred and eighty probands, aged 0.8-14.9 years, were examined for islet cell antibodies (ICA) and insulin autoantibodies (IAA), while 769 probands were studied for antibodies to glutamic acid decarboxylase (GAD65A). |
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| 11561476 | Gonzalez de Pijem L, Nieves-Rivera F: Insulin autoantibodies: evidence of autoimmune disease among a group of Puerto Rican children with newly diagnosed type 1 diabetes mellitus. P R Health Sci J. 2001 Jun;20(2):161-4. To this end, 20 children (8 males, 12 females), ages 1-15 years, admitted to the University Pediatric Hospital with type 1 diabetes de novo between November 2000 and April 2001 were prospectively studied to determine the presence of serum antibodies against Islet cells (ICA), glutamic acid decarboxylase (GAD-65) and insulin autoantibodies (IAA). |
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| 16025255 | Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lahde J, Simell O, Knip M, Ilonen J: The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. Diabetologia. 2005 Sep;48(9):1766-75. Epub 2005 Jul 16. Infants carrying increased risk HLA DQB1 genotypes were monitored for the appearance of autoantibodies (islet cell autoantibodies [ICA], insulin autoantibodies [IAA], glutamic acid decarboxylase autoantibodies [GADA] and islet antigen 2 antibodies [IA-2A]). |
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| 15804058 | Zhou ZG, Yang L, Huang G: Diagnostic value of carboxypeptidase-H autoantibodies in detecting latent autoimmune diabetes in adults. Hunan Yi Ke Da Xue Xue Bao. 2003 Dec;28(6):549-52. Radioimmunoassay was applied to detect antibodies to glutamic acid decarboxylase (GAD-Ab), intracellular part of protein tyrosine phosphatase-like protein (IA2ic-Ab), and autoantibodies to insulin (IAA). |
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| 18036312 | Wang JP, Zhang C, Lin J, Yuan Y, Zhou HF, Huang G, Zhou M, Zhou ZG: [Relationship between autoantibodies and HLA-DQ genotypes in patients with type 1 diabetes mellitus]. Zhonghua Yi Xue Za Zhi. 2007 Sep 11;87(34):2380-4. OBJECTIVE: To explore the relationship between the 3 islet autoantibodies, i.e., glutamic acid decarboxylase antibody (GADA), protein-tyrosine-phosphatase-2 autoantibody (IA-2A), and insulin autoantibody (IAA), and human leukocyte HLA-DQ genotypes in the patients with type 1 diabetes mellitus (T1DM). |
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| 14563016 | Elfving AM, Lindberg BA, Nystrom L, Sundkvist G, Lernmark A, Ivarsson SA: Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age. J Pediatr Endocrinol Metab. 2002 Jun;15(6):831-40. Cord blood sera from 30 patients who developed type 1 diabetes between 15 and 25 years of age and sera from 320 randomly selected control children were tested for islet cell antibodies (ICA) by indirect immunofluorescence and autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GADA), islet cell antigen-2 (IA-2A) and insulin (IAA) by radiobinding assays. |
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| 9451598 | Dotta F, Falorni A, Tiberti C, Dionisi S, Anastasi E, Torresi P, Lernmark A, Di Mario U: Autoantibodies to the -1 islet ganglioside and to GAD-65 at type 1 diabetes onset. J Autoimmun. 1997 Dec;10(6):585-8. Anti-ganglioside autoantibodies were determined using an indirect immunoperoxidase technique performed directly on TLC plates in the following groups of patients: (a) newly diagnosed type 1 diabetic subjects before insulin therapy (n = 45); all were tested for GAD65 autoantibodies in a fluid-phase RIA using 35S--labelled recombinant human GAD65. |
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| 16061004 | Zhang C, Zhou ZG, Zhang DM, Yang XL, Zhou M, Lin J, Huang G, Wang JP: [Clinical and immunological characteristics in rapid-onset type 1 diabetes with hyperamylasemia]. Autoimmun Rev. 2006 Jul;5(6):424-8. Epub 2005 Dec 29. Islet autoantibodies, including glutamic acid decarboxylase antibody (GAD-Ab), protein tyrosine phosphatase antibody (IA-2Ab) and insulin autoantibody (IAA),, were detected by radioligand assays. |
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| 12672406 | Koczwara K, Schenker M, Schmid S, Kredel K, Ziegler AG, Bonifacio E: Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse. Clin Immunol. 2003 Feb;106(2):155-62. To address this, antibody titer and subclass to insulin, glutamic acid decarboxylase (GAD) 65, IA-2, and IA-2beta proteins were measured by radiobinding assays in untreated or immunized female nonobese diabetic mice. |
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| 11200711 | Nazaimoon WM, Azmi KN, Rasat R, Ismail IS, Singaraveloo M, Mohamad WB, Letchuman R, Sheriff IH, Faridah I, Khalid BA: Autoimmune markers in young Malaysian patients with type 1 diabetes mellitus. Med J Malaysia. 2000 Sep;55(3):318-23. This study determined the prevalence and significance of autoantibodies to GAD65 (GAD Ab), insulin (IAA), -like phosphatase (IA2) and islet-cell (ICA) in a group of 213 young Malaysian Type 1 diabetics, diagnosed before the age of 40 years. |
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| 11221998 | Maniatis AK, Yu L, Miao D, Nelson K, Eisenbarth GS: Rapid assays for detection of anti-islet autoantibodies: implications for organ donor screening. J Autoimmun. 2001 Feb;16(1):71-6. The purpose of the current study was to develop and evaluate rapid assays for autoantibodies to GAD65 (GAA), ICA512bdc/IA-2 (ICA512AA), and insulin (microIAA, mIAA) as a potential tool for identification of cadaveric pancreas donors who were at high risk for developing diabetes. |
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| 11921419 | Hamalainen AM, Ilonen J, Simell O, Savola K, Kulmala P, Kupila A, Simell T, Erkkola R, Koskela P, Knip M: Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers. Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):57-63. METHODS: The samples were analysed for cytoplasmic islet cell antibodies (ICA), autoantibodies to the 65 kD isoform of glutamic acid decarboxylase (GADA), autoantibodies to the protein tyrosine phosphatase related IA-2 antigen (IA-2A), insulin autoantibodies (IAA) and HLA DQB1 genotypes. |
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| 15386804 | Larsson K, Elding-Larsson H, Cederwall E, Kockum K, Neiderud J, Sjoblad S, Lindberg B, Lernmark B, Cilio C, Ivarsson SA, Lernmark A: Genetic and perinatal factors as risk for childhood type 1 diabetes. Zhonghua Yi Xue Za Zhi. 2005 Apr 13;85(14):967-71. Cord blood is analysed for HLA high-risk alleles and for autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GADA), the protein tyrosine phosphatase-related IA-2 antigen (IA-2A) and insulin (IAA) as a measure of prenatal autoimmune exposure. |
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| 17381505 | Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T: Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission. Diabet Med. 2007 May;24(5):512-20. Epub 2007 Mar 22. In addition, autoantibodies against insulin (IAA), IA-2 (IA-2A) and GAD65 (GADA) were quantified. |
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