Protein Information

Name CLIC1
Synonyms CLIC 1; CLIC1; Chloride channel ABP; Chloride intracellular channel 1; Chloride intracellular channel protein 1; G6; NCC27; Nuclear chloride ion channel 27…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
15190104 Novarino G, Fabrizi C, Tonini R, Denti MA, Malchiodi-Albedi F, Lauro GM, Sacchetti B, Paradisi S, Ferroni A, Curmi PM, Breit SN, Mazzanti M: Involvement of the intracellular ion channel CLIC1 in microglia-mediated beta-amyloid-induced neurotoxicity. J Neurosci. 2004 Jun 9;24(23):5322-30.

7(0,0,0,7) Details
17347778 Edwards JC: The CLIC1 chloride channel is regulated by the cystic fibrosis transmembrane conductance regulator when expressed in Xenopus oocytes. J Membr Biol. 2006;213(1):39-46. Epub 2007 Mar 8.

6(0,0,0,6) Details
18438938 Paradisi S, Matteucci A, Fabrizi C, Denti MA, Abeti R, Breit SN, Malchiodi-Albedi F, Mazzanti M: Blockade of chloride intracellular ion channel 1 stimulates Abeta phagocytosis. J Neurosci Res. 2008 Aug 15;86(11):2488-98.


In amyloid-beta (Abeta)-stimulated microglial cells, blockade of chloride intracellular ion channel 1 (CLIC1) reverts the increase in tumor necrosis factor-alpha and nitric oxide (NO) production and results in neuroprotection of cocultured neurons.
5(0,0,0,5) Details
17927776 Ducharme G, Newell EW, Pinto C, Schlichter LC: Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia. Eur J Neurosci. 2007 Oct;26(8):2119-30. Epub 2007 Oct 1.


Microglia express several candidate genes, with relative mRNA expression levels of: CLIC1 > ClC3 > I (Cln) > or = ClC2 > Best2 > Best1 > or = Best3 > Best4.
1(0,0,0,1) Details