| Name | glyceraldehyde 3 phosphate dehydrogenase |
|---|---|
| Synonyms | CDABP0047; G3PD; GAPD; GAPD protein; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; GAPD proteins; Glyceraldehyde 3 phosphate dehydrogenases |
| Name | IAA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10937934 | Even S, Garrigues C, Loubiere P, Lindley ND, Cocaign-Bousquet M: Pyruvate metabolism in Lactococcus lactis is dependent upon glyceraldehyde-3-phosphate dehydrogenase activity. Metab Eng. 1999 Jul;1(3):198-205. |
6(0,0,0,6) | Details |
| 19584905 | Schmidt MM, Dringen R: Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes. Front Neuroenergetics. 2009;1:1. Epub 2009 Mar 24. Iodoacetamide (IAA) and iodoacetate (IA) have frequently been used to inhibit glycolysis, since these compounds are known for their ability to irreversibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). |
3(0,0,0,3) | Details |
| 19367647 | Cardenas-Rodriguez N, Guzman-Beltran S, Medina-Campos ON, Orozco-Ibarra M, Massieu L, Pedraza-Chaverri J: The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons. J Biochem Mol Toxicol. 2009 Mar;23(2):137-42. Taking into account some evidence about neuroprotective effects elicited by NDGA, we evaluated the effect of this compound on the neurotoxicity induced by iodoacetate (IAA), an inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), on cerebellar granule neurons. |
2(0,0,0,2) | Details |
| 17725817 | Gallis JL, Tissier P, Gin H, Beauvieux MC: Decrease in oxidative phosphorylation yield in presence of in perfused liver isolated from fed rats. BMC Physiol. 2007 Aug 28;7:8. The rate of ATP synthesis was determined in the steady state by monitoring the rate of ATP loss after inhibition of (i) cytochrome oxidase (oxidative phosphorylation) with KCN (2.5 mmol/L) and (ii) glyceraldehyde 3-phosphate dehydrogenase (glycolysis) with IAA (0.5 mmol/L). |
1(0,0,0,1) | Details |
| 12714331 | Harrison GJ, van Wijhe MH, de Groot B, Dijk FJ, Gustafson LA, van Beek JH: Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to kinase. Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H883-90. Epub 2003 Apr 24. Tyrode-perfused hearts were exposed to 15 min of the following: 1) 0.4 mM iodoacetamide (IA; n = 6) to block CK (CK activity <3% vs. control), 2) 0.3 mM iodoacetic acid (IAA; n = 5) to inhibit glycolysis (GAPDH activity <3% vs. control), or 3) vehicle (control, n = 7) at 37 degrees C. |
1(0,0,0,1) | Details |
| 11677264 | Guo Z, Lee J, Lane M, Mattson M: Iodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat-shock proteins and Bcl-2. J Neurochem. 2001 Oct;79(2):361-70. In the present study we employed iodoacetic acid (IAA), an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, to test the hypothesis that inhibition of glycolysis can protect neurons. |
1(0,0,0,1) | Details |
| 10215508 | Rego AC, Areias FM, Santos MS, Oliveira CR: Distinct glycolysis inhibitors determine retinal cell sensitivity to -mediated injury. Neurochem Res. 1999 Mar;24(3):351-8. Three different approaches were used to inhibit glycolysis: the cells were submitted to iodoacetic acid (IAA), an inhibitor of glyceraldehyde 3-phosphate dehydrogenase, to 2-deoxy- (DG) in -free medium, which was used as a substitute of or in the absence of |
1(0,0,0,1) | Details |