Protein Information

Name CoA synthase
Synonyms Bifunctional coenzyme A synthase; PPAT; Bifunctional phosphopantetheine adenylyl transferase; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; Bifunctional phosphopantetheine adenylyl transferase/dephospho Coenzyme A kinase; COASY; CoA synthase; Coenzyme A synthase…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
14984735 Tomoda H, Ohbayashi N, Morikawa Y, Kumagai H, Omura S: Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.


We studied the molecular mechanism through which the fungal beta-lactone, hymeglusin, potently and specifically inhibits 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase. [(14) C] Hymeglusin covalently bound to purified rat liver and to recombinant hamster cytosolic HMG-CoA synthases.		 5(0,0,0,5) Details