| 15774759 |
Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW: Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science. 2005 Mar 18;307(5716):1776-8.
Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2 (GCN2) kinase. |
81(1,1,1,1) |
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