Protein Information

Name glucagon
Synonyms GCG; GLP 1; GLP1; GLP 2; GLP2; GRPP; Glicentin related polypeptide; Glucagon…

Compound Information

Name IAA
CAS

Reference List

PubMed Abstract RScore(About this table)
11200711 Nazaimoon WM, Azmi KN, Rasat R, Ismail IS, Singaraveloo M, Mohamad WB, Letchuman R, Sheriff IH, Faridah I, Khalid BA: Autoimmune markers in young Malaysian patients with type 1 diabetes mellitus. Med J Malaysia. 2000 Sep;55(3):318-23.


Venous blood was taken at fasting, and at 6 minutes post-glucagon (1 mg i.v.).
2(0,0,0,2) Details
10200135 Berberoglu M, Ocal G, Ikinciogullari A, Adiyaman P, Cetinkaya E, Tutar E, Babacan E: Evaluation of the pancreas reserve in siblings of type I diabetic children. Pediatr Int. 1999 Feb;41(1):42-5.


For siblings of the diabetic children, fasting, post-prandial and glucagon response C-peptide mean values were 2.2 +/- 1.2, 7.2 +/- 7.1 and 5.3 +/- 3.6 ng/mL, respectively, while in the control group they were 1.5 +/- 0.8, 3.6 +/- 2.0 and 5.1 +/- 2.9 ng/mL, respectively.
2(0,0,0,2) Details
12687930 Szepietowska B, Szelachowska M, Gorska M, Stepien A, Kinalska I: [Clinical, biochemical and immunological characteristic of diabetes type I, LADA, diabetes type II, and MODY patients]. Pol Arch Med Wewn. 2002 Dec;108(6):1177-84.


We measured basal and stimulated C-peptide (6 minutes after 1 mg i.v. glucagon) (ELISA) and antibodies titers to glutamic acid decarboxylase--antiGAD65, tyrosine phosphatase-like molecule--IA2 and insulin--IAA (RIA).
1(0,0,0,1) Details
20061360 Miller ME, Bonds DE, Gerstein HC, Seaquist ER, Bergenstal RM, Calles-Escandon J, Childress RD, Craven TE, Cuddihy RM, Dailey G, Feinglos MN, Ismail-Beigi F, Largay JF, O'Connor PJ, Paul T, Savage PJ, Schubart UK, Sood A, Genuth S: The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010 Jan 8;340:b5444. doi: 10.1136/bmj.b5444.


MAIN OUTCOME MEASURES: Severe hypoglycaemia was defined as episodes of "low blood glucose" requiring the assistance of another person and documentation of either a plasma glucose less than 2.8 mmol/l (<50 mg/dl) or symptoms that promptly resolved with oral carbohydrate, intravenous glucose, or glucagon.
1(0,0,0,1) Details
9627364 Barazzoni R, Zanetti M, Vettore M, Tessari P: Relationships between phenylalanine hydroxylation and plasma aromatic amino acid concentrations in humans. Metabolism. 1998 Jun;47(6):669-74.


We investigated the relationships between phenylalanine hydroxylation (Phe Hy) and plasma concentrations of phenylalanine, tyrosine, and glucagon in healthy male volunteers (N = 13; age, 29 +/- 3 years).
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12482194 Rolandsson O, Haney MF, Hagg E, Biber B, Lernmark A: Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?. Autoimmunity. 2002 Jul;35(4):261-4.


The pathoanatomical examination showed atrophy of the beta-cell population, depletion of insulin with preserved glucagon content.
1(0,0,0,1) Details
10937518 Betterle C, Fabris P, Zanchetta R, Pedini B, Tositti G, Bosi E, de Lalla F: Autoimmunity against pancreatic islets and other tissues before and after interferon-alpha therapy in patients with hepatitis C virus chronic infection. Diabetes Care. 2000 Aug;23(8):1177-81.


Autoantibodies to islet cell (ICA), glucagon-producing cells (GCA), parietal cell (PCA), adrenal cortex (ACA), adrenal medulla (AdMA), nuclei (ANA), liver-kidney microsomal (LKM-Ab), mitochondrial, and smooth muscle (SMA) were tested using the classic indirect immunofluorescence technique.
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16832790 Szepietowska B, Szelachowska M, Gorska M: [Family incidence of latent autoimmune diabetes in adults--case report] . Endokrynol Pol. 2006 May-Jun;57(3):254-7.


However plasma level of C peptide basal and after stimulation with glucagon was reduced.
1(0,0,0,1) Details
12605834 Aguilera E, Recasens M, Morinigo RA, Casamitjana R, Oriola J, Ercilla G, Conget I: [Clinical, metabolic, immunologic and genotypic characteristics in non-pediatric patients with type 1A diabetes mellitus. Med Clin. 2003 Feb 8;120(4):121-4.


Pancreatic cell function was assessed by glucagon test (at onset and at 12 months).
1(0,0,0,1) Details