Protein Information

Name plasminogen activator inhibitor 1
Synonyms Endothelial plasminogen activator inhibitor; PAI; PAI 1; PAI1; PAIE; PLANH 1; Plasminogen activator inhibitor 1…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
15242553 Franke K, Curth K, Lenart J, Knochenhauer D, Kietzmann T: Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase. Antioxid Redox Signal. 2004 Aug;6(4):721-8.

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12774341 Kidokoro A, Iba T, Hong J: Role of DIC in multiple organ failure. . Int J Surg Investig. 2000;2(1):73-80.


RESULTS AND CONCLUSION: Damaged vascular endothelial cells overproduce plasminogen activator inhibitor 1, which, with excess production of thrombin, leads to fibrnolysis-suppressive DIC and fibrin formation in the microvasculature.
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15614127 Iba T, Kidokoro A, Fukunaga M, Sugiyama K, Sawada T, Kato H: Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers. Shock. 2005 Jan;23(1):25-9.


In contrast, fibrin/fibrinogen degradation products, D-dimer, thrombin-antithrombin complex, plasmin alpha2-antiplasmin complex, soluble fibrin, and total plasminogen activator inhibitor-1 were significantly higher, and the antithrombin activity and protein C levels were lower in the patients with organ dysfunction.
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8696988 Kidokoro A, Iba T, Fukunaga M, Yagi Y: Alterations in coagulation and fibrinolysis during sepsis. . Shock. 1996 Mar;5(3):223-8.


Tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and thrombomodulin were also measured.
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1903823 Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE: Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. J Surg Res. 1991 May;50(5):457-60.


EC have been demonstrated to release tissue type plasminogen activator (t-PA) and its rapid inhibitor type 1 plasminogen activator inhibitor (PAI-1).
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1285345 Iba T, Sumpio BE: Tissue plasminogen activator expression in endothelial cells exposed to cyclic strain in vitro. Cell Transplant. 1992;1(1):43-50.


The effects of cyclic strain on the production of tissue plasminogen activator (tPA) and type 1 plasminogen activator inhibitor (PAI-1) by cultured endothelial cells (EC) were examined.
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