Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
17993956 Iba T, Gando S, Murata A, Kushimoto S, Saitoh D, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, Mayumi T, Ikeda T, Ishhikura H, Ueyama M, Ogura Y, Endo S, Shimazaki S: Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers. J Trauma. 2007 Nov;63(5):1093-8.


RESULTS: Significant changes between the groups were observed in platelet count, fibrin or fibrinogen degradation products, interleukin-6, soluble thrombomodulin, antithrombin (AT) activity, and protein C activity, both on day 0 and on day 2.
1(0,0,0,1) Details
14501901 Iba T, Kidokoro A, Fukunaga M, Fuse S, Suda M: Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse. J Trauma. 2003 Sep;55(3):546-50.


A comparison of the intercellular adhesion molecule-1 (p < 0.05), soluble tumor necrosis factor-alpha receptor (p < 0.05), and interleukin-6 (p < 0.01) levels showed less increase in the treated mice.
1(0,0,0,1) Details
19410369 Hathway GJ, Vega-Avelaira D, Moss A, Ingram R, Fitzgerald M: Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates. Pain. 2009 Jul;144(1-2):110-8. Epub 2009 May 1.


C-fibre evoked sensitization was accompanied by significant microglial activation, shown by increased Iba-1 immunoreactivity throughout the dorsal horn at 24 and 48 h and significant upregulation of markers of microglial activation: IL-6 and Mcp-1 at 3h and Mmp3, CSF-1 and CD163 at 24 and 48 h.
1(0,0,0,1) Details
12909491 Iwabe T, Harada T, Sakamoto Y, Iba Y, Horie S, Mitsunari M, Terakawa N: Gonadotropin-releasing hormone agonist treatment reduced serum interleukin-6 concentrations in patients with ovarian endometriomas. Fertil Steril. 2003 Aug;80(2):300-4.

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18362111 Sappington RM, Calkins DJ: Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3004-17. Epub 2008 Mar 24.

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16429448 Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, Okano H: Proinflammatory cytokines expression in noise-induced damaged cochlea. . J Neurosci Res. 2006 Mar;83(4):575-83.


Among several detected cytokines, real-time RT-PCR showed that interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were significantly induced 3 hr after noise exposure, and quickly downregulated to the basal level.
6(0,0,0,6) Details
7549268 Iba T, Yagi Y, Kidokoro A, Fukunaga M, Fukunaga T: Increased plasma levels of soluble thrombomodulin in patients with sepsis and organ failure. Surg Today. 1995;25(7):585-90.


In this study, we examined the changes in plasma levels of TM in 60 septic patients and 13 postsurgical patients, and investigated the circulating levels of interleukin 6 (IL-6) and polymorphonuclear leukocyte elastase (PMN-E) to determine the mechanism causing the excess liberation of TM.
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18601748 Iba T, Miyasho T: Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats. Crit Care. 2008;12(4):R86. Epub 2008 Jul 6.


The elevation of proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 was significantly suppressed in the DA group.
1(0,0,0,1) Details
19374947 White CL, Pistell PJ, Purpera MN, Gupta S, Fernandez-Kim SO, Hise TL, Keller JN, Ingram DK, Morrison CD, Bruce-Keller AJ: Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis. 2009 Jul;35(1):3-13. Epub 2009 Apr 15.


HFD was also associated with significant increases in 3-nitrotyrosine, inducible nitric oxide synthase, IL-6, and glial markers Iba-1 and GFAP, with the largest increases frequently observed in HFD animals born to HFD dams.
1(0,0,0,1) Details
15699841 Iba T, Kidokoro A, Fukunaga M, Nagakari K, Shirahama A, Ida Y: Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model. Crit Care Med. 2005 Feb;33(2):368-72.


In another series, tumor necrosis factor, interleukin-6, alanine transaminase, and blood urea nitrogen levels were evaluated (n = 5).
1(0,0,0,1) Details
11837793 Iba T, Kidokoro A, Fukunaga M, Fuse S, Suda M, Kunitada S, Hara T: Factor Xa-inhibitor (DX-9065a) modulates the leukocyte-endothelial cell interaction in endotoxemic rat. Shock. 2002 Feb;17(2):159-62.


In addition, TNF, IL-6, alanine aminotransferase (ALT), blood urea nitrogen (BUN), and lactate levels were measured.
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