Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
8894142 Iba K, Sawada N, Nuka S, Chiba H, Obata H, Isomura H, Satoh M, Ishii S, Mori M: Phase-Dependent effects of transforming growth factor beta 1 on osteoblastic markers of human osteoblastic cell line sV-HFO during mineralization. Bone. 1996 Oct;19(4):363-9.


In this study, we examined the effects of transforming growth factor beta 1 (TGF-beta 1) on the mineralization of SV-HFO cells and show that TGF-beta 1 inhibited the mineralization of the cells via down regulation of tetranectin and alkaline phosphatase without influencing other osteoblastic markers.
3(0,0,0,3) Details
15490270 Iba K, Takada J, Yamashita T: The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients. J Bone Miner Metab. 2004;22(6):594-6.

3(0,0,0,3) Details
11699639 Iba K, Chiba H, Yamashita T, Ishii S, Sawada N: Phase-independent inhibition by retinoic acid of mineralization correlated with loss of tetranectin expression in a human osteoblastic cell line. Cell Struct Funct. 2001 Aug;26(4):227-33.


We have recently reported that retinoic acid inhibits dexamethasone-induced alkaline phosphatase activity and mineralization in human osteoblastic cell line SV-HFO.
2(0,0,0,2) Details
9149901 Kameda T, Watanabe H, Iba H: C-Jun and JunD suppress maturation of chondrocytes. . Cell Growth Differ. 1997 May;8(5):495-503.


When US cells were treated with parathyroid hormone (PTH), which prevented maturation as judged from the maturation-associated markers such as alkaline phosphatase and type X collagen, the expression levels of c-Jun and JunD were constitutively elevated.
2(0,0,0,2) Details
7589422 Iba K, Sawada N, Chiba H, Wewer UM, Ishii S, Mori M: Transforming growth factor-beta 1 downregulates dexamethasone-induced tetranectin gene expression during the in vitro mineralization of the human osteoblastic cell line SV-HFO. FEBS Lett. 1995 Oct 2;373(1):1-4.


We found that the expression of tetranectin and alkaline phosphatase mRNA was induced by dexamethasone treatment as evidenced by Northern blotting.
2(0,0,0,2) Details
11737589 Uchiyama-Tanaka Y, Matsubara H, Nozawa Y, Murasawa S, Mori Y, Kosaki A, Maruyama K, Masaki H, Shibasaki Y, Fujiyama S, Nose A, Iba O, Hasagawa T, Tateishi E, Higashiyama S, Iwasaka T: Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int. 2001 Dec;60(6):2153-63.


In mesangial cells stably transfected with a chimeric construct containing HB-EGF and alkaline phosphatase (ALP) genes, ALP activity in incubation medium was rapidly increased by Ang II (1.7-fold at 0.5 min) and reached a 4.1-fold increase at two minutes.
1(0,0,0,1) Details
8865066 Albillos A, Gandia L, Michelena P, Gilabert JA, del Valle M, Carbone E, Garcia AG: The mechanism of calcium channel facilitation in bovine chromaffin cells. J Physiol. 1996 Aug 1;494 ( Pt 3):687-95.

Treatment of SVL with alkaline phosphatase or dialysis against a saline buffer to remove low molecular mass materials (< 10 kDa) considerably reduced the activity of SVL. 6.
A 1:1000 dilution of SVL in the external solution halved the magnitude of IBa and produced a 7-fold slowing of its activation kinetics.
1(0,0,0,1) Details