| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | IBA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9651396 | Shistik E, Ivanina T, Blumenstein Y, Dascal N: Crucial role of N terminus in function of cardiac L-type Ca2+ channel and its modulation by protein kinase C. J Biol Chem. 1998 Jul 10;273(28):17901-9. The well documented increase of IBa caused by activation of protein kinase C (PKC) was fully eliminated by the 46-a.a. deletion. |
82(1,1,1,2) | Details |
| 2435866 | Leonard JP, Nargeot J, Snutch TP, Davidson N, Lester HA: Ca channels induced in Xenopus oocytes by rat brain mRNA. J Neurosci. 1987 Mar;7(3):875-81. However, IBa was enhanced via activation of protein kinase C with 4-beta-phorbol dibutyrate (PBT2). |
81(1,1,1,1) | Details |
| 8046455 | Zong X, Lux HD: Augmentation of calcium channel currents in response to G protein activation by GTP gamma S in chick sensory neurons. J Neurosci. 1994 Aug;14(8):4847-53. Augmentation of IBa was eliminated by pertussis toxin (PTX) infusion or pretreatment, but was also prevented by intracellularly infusing protein kinase C (PKC) inhibitors together with GTP gamma S. |
31(0,1,1,1) | Details |
| 2159060 | Doerner D, Abdel-Latif M, Rogers TB, Alger BE: Protein kinase C-dependent and -independent effects of phorbol esters on hippocampal calcium channel current. J Neurosci. 1990 May;10(5):1699-706. While both phorbol esters depressed whole-cell barium current through Ca channels (IBa), PDBu was approximately 100-fold more potent than 4 alpha-PDBu. |
2(0,0,0,2) | Details |
| 8543041 | Bouron A, Soldatov NM, Reuter H: The beta 1-subunit is essential for modulation by protein kinase C of an human and a non-human L-type Ca2+ channel. FEBS Lett. 1995 Dec 18;377(2):159-62. DHP-insensitive Ba2+ currents (IBa) were recorded from endogenous channels in non-injected oocytes and in oocytes injected with cRNAs encoding the auxiliary rabbit alpha 2/delta and beta 1 Ca2+ channel subunits. |
2(0,0,0,2) | Details |
| 7971149 | Bouron A, Reber BF: Differential modulation of pharmacologically distinct components of Ca2+ currents by protein kinase C activators and phosphatase inhibitors in nerve-growth-factor-differentiated rat pheochromocytoma (PC12) cells. Pflugers Arch. 1994 Jul;427(5-6):510-6. By using omega-conotoxin (CgTX) and isradipine, two specific Ca2+ channel blockers, we found three types of Ba2+ currents (IBa): (1) a omega-CgTX-sensitive IBa; (2) an isradipine-sensitive IBa; and (3) a omega-CgTX plus isradipine-resistant IBa. |
2(0,0,0,2) | Details |
| 2541856 | Dolphin AC, McGuirk SM, Scott RH: An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by nucleotide analogues and (-)-baclofen. Br J Pharmacol. 1989 May;97(1):263-73. The effect of protein kinase C inhibitors was examined. The inhibition by GTP-gamma-S is particularly characterized by an abolition of the transient component of calcium channel currents carried either by Ba2+ (IBa) or by Ca2+ (ICa). 2. |
1(0,0,0,1) | Details |
| 9127843 | Ahn SC, Kim YC, Kim SJ, So I, Kim KW: Dual roles of phorbol 12, 13-dibutyrate in the regulation of guinea-pig gastric contraction. J Smooth Muscle Res. 1997 Feb;33(1):11-22. We performed experiments to investigate the actions of protein kinase C (PKC) on mechanical contraction during agonist stimulation in guinea pig stomach. Voltage-dependent Ba2+ current (IBa) was increased by PDBu (212 +/- 32.2% of steady state currents, n = 5), while CCh-induced increase of IK (Ca) transient was inhibited by PDBu (n = 5), the changes of which were similar to those of muscle contractions. |
1(0,0,0,1) | Details |
| 10856308 | Murasawa S, Matsubara H, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Kitabayashi I, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Iba S, Iwasaka T: Angiotensin II initiates kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase. J Biol Chem. 2000 Sep 1;275(35):26856-63. Ang II markedly stimulated JNK activities, which were abolished by and intracellular Ca (2+) chelators but partially by protein kinase C depletion. |
1(0,0,0,1) | Details |
| 1335820 | Doerner D, Alger BE: Evidence for hippocampal calcium channel regulation by PKC based on comparison of diacylglycerols and phorbol esters. Brain Res. 1992 Nov 27;597(1):30-40. Studies using phorbol esters imply that hippocampal Ca2+ channels are regulated by protein kinase C (PKC); however concerns have been raised because in some circumstances phorbol esters have non-specific effects on ion channels. We found that, like PDBu, the diacylglycerols (DAGs) suppressed whole-cell Ba2+ current (IBa) in a dose-dependent and reversible manner and caused a hyperpolarizing shift in the voltage dependence of steady-state IBa inactivation. |
1(0,0,0,1) | Details |
| 11737589 | Uchiyama-Tanaka Y, Matsubara H, Nozawa Y, Murasawa S, Mori Y, Kosaki A, Maruyama K, Masaki H, Shibasaki Y, Fujiyama S, Nose A, Iba O, Hasagawa T, Tateishi E, Higashiyama S, Iwasaka T: Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int. 2001 Dec;60(6):2153-63. The processing and release of binding-endothelin growth factor (HB-EGF) are activated by protein kinase C (PKC) and Ca2+ signaling. |
1(0,0,0,1) | Details |
| 11139469 | Fujiyama S, Matsubara H, Nozawa Y, Maruyama K, Mori Y, Tsutsumi Y, Masaki H, Uchiyama Y, Koyama Y, Nose A, Iba O, Tateishi E, Ogata N, Jyo N, Higashiyama S, Iwasaka T: Angiotensin AT (1) and AT (2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circ Res. 2001 Jan 19;88(1):22-9. Ang II significantly induced Ang2 mRNA accumulations without affecting Ang1 or Tie2 expression, which was inhibited by protein kinase C inhibitors and by intracellular Ca (2+) chelating agents. |
1(0,0,0,1) | Details |
| 9914387 | Seki T, Yokoshiki H, Sunagawa M, Nakamura M, Sperelakis N: Angiotensin II stimulation of Ca2+-channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY-294002. Pflugers Arch. 1999 Feb;437(3):317-23. In vascular smooth muscle (VSM) cells, AngII is known to activate enzymes such as protein kinase (Tyr-PK), phospholipase C (PLC), protein kinase C (PKC), and phophatidylinositol-3-kinase (PI-3-K). Application of 50 nM AngII significantly increased the amplitude of Ba2+ currents through the voltage-gated Ca2+ channels (IBa) by 34. 5+/-9.1% (n=10) within 1 min. |
1(0,0,0,1) | Details |
| 10226153 | Zhong J, Dessauer CW, Keef KD, Hume JR: Regulation of L-type Ca2+ channels in rabbit portal vein by G protein alphas and betagamma subunits. J Physiol. 1999 May 15;517 ( Pt 1):109-20. These data indicate that enhancement of Ba2+ currents by Galphas and Gbetagamma can be attributed to increased activity of protein kinase A and protein kinase C, respectively. Cells dialysed with either Galphas or Gbetagamma exhibited significant increases in peak Ba2+ current (IBa) density (148 % and 131 %, respectively) compared with control cells. |
1(0,0,0,1) | Details |
| 8381362 | Fournier F, Charnet P, Bourinet E, Vilbert C, Matifat F, Charpentier G, Navarre P, Brule G, Marlot D: Regulation by protein kinase-C of putative P-type Ca channels expressed in Xenopus oocytes from cerebellar mRNA. FEBS Lett. 1993 Feb 8;317(1-2):118-24. Xenopus oocytes injected with rat cerebellar mRNA expressed functional voltage-dependent Ca channels detected as an inward Ba current (IBa). |
1(0,0,0,1) | Details |
| 7500129 | Ishibashi H, Akaike N: Somatostatin modulates high-voltage-activated Ca2+ channels in freshly dissociated rat hippocampal neurons. J Neurophysiol. 1995 Sep;74(3):1028-36. SS showed the activation phase of Ba2+ current (IBa) passing through HVA Ca2+ channels, and the maximum inhibition was 28% of the total current amplitude measured 10 ms after the current activation. |
0(0,0,0,0) | Details |
| 8528575 | Nagano N, Imaizumi Y, Watanabe M: Modulation of calcium channel currents by in single smooth muscle cells from vas deferens of the guinea-pig. Br J Pharmacol. 1995 Sep;116(2):1887-93. When Ca2+ or Ba2+ was the charge carrier, Ca channel current (ICa or IBa) was reduced by AA to a similar extent (IC50 = 10 and 6 microM, respectively). |
0(0,0,0,0) | Details |
| 2159598 | Solntseva EI: [The mechanisms of the inhibiting action of cyclic on the current of intact mollusk neurons]. Neirofiziologiia. 1990;22(1):54-61. The inhibitory effect of cAMP on the ICa was investigated as well as on the IBa. |
0(0,0,0,0) | Details |