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Abad T, McNaughton-Smith G, Fletcher WQ, Echeverri F, Diaz-Penate R, Tabraue C, Ruiz de Galarreta CM, Lopez-Blanco F, Luis JG: Isolation of (S)-(+)-naproxene from Musa acuminata. Planta Med. 2000 Jun;66(5):471-3.
Inhibitory effect of naproxene and its 7-methoxy isomer on constitutive COX-1 and inducible COX-2.. |
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Fiorucci S, Di Lorenzo A, Renga B, Farneti S, Morelli A, Cirino G: Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy) butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. J Pharmacol Exp Ther. 2004 Dec;311(3):1264-71. Epub 2004 Aug 5.
Administration of selective and nonselective cyclooxygenase (COX)-2 inhibitors to rheumatoid arthritis patients taking low doses of acetylsalicylic acid (ASA) for cardiovascular prevention associates with increased risk of gastrointestinal bleeding. |
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