| Name | calmodulin |
|---|---|
| Synonyms | CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3… |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2957417 | Sahib IK, Prasada Rao KS, Desaiah D: Pyrethroid inhibition of basal and calmodulin stimulated Ca2+ ATPase and adenylate cyclase in rat brain. J Appl Toxicol. 1987 Apr;7(2):75-80. Effects of two classes of pyrethroids, permethrin and resmethrin (type I), cypermethrin and deltamethrin (type II), on basal (calmodulin-deficient) and calmodulin stimulated activities of Ca2+ ATPase and adenylate cyclase from rat brain were studied in vitro. |
10(0,0,1,5) | Details |
| 16678970 | Wu ZZ, Chen SR, Pan HL: Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience. 2006 Aug 11;141(1):407-19. Epub 2006 May 6. Furthermore, calcineurin (protein phosphatase 2B) inhibitors (deltamethrin and FK-506) eliminated the effect of olvanil on voltage-activated Ca (2+) channel current. Calmodulin antagonists (ophiobolin-A and calmodulin inhibitory peptide) largely blocked the effect of olvanil and on voltage-activated Ca (2+) channel current. |
3(0,0,0,3) | Details |
| 10807662 | Wirkner K, Assmann H, Koles L, Gerevich Z, Franke H, Norenberg W, Boehm R, Illes P: Inhibition by A (2A) receptors of but not AMPA currents in rat neostriatal neurons. Br J Pharmacol. 2000 May;130(2):259-69. The calcineurin inhibitor deltamethrin did not interfere with CGS 21680. It is suggested that the transduction mechanism of A (2A) receptors to inhibit NMDA receptor channels is the phospholipase C/InsP (3)/calmodulin and calmodulin kinase II pathway. |
1(0,0,0,1) | Details |
| 17551263 | Martin C, Jacobi JS, Nava G, Jeziorski MC, Clapp C, Martinez de la Escalera G: inhibition of cyclic AMP production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl cyclase 9. Neuroendocrinology. 2007;85(4):257-66. Epub 2007 Jun 4. In addition, blocking Ca2+/calmodulin-dependent protein kinase II (CamKII) with KN-62 partially reversed the action of suggesting that AC3 may also be involved in this effect. Furthermore, blocking calcineurin with deltamethrin, FK-506 or cyclosporin A blocked the inhibitory effect of on [cAMP] i, supporting the involvement of AC9 in this effect. |
1(0,0,0,1) | Details |
| 8619889 | Enan E, Pinkerton KE, Peake J, Matsumura F: Deltamethrin-induced thymus atrophy in male Balb/c mice. Biochem Pharmacol. 1996 Feb 23;51(4):447-54. In addition, deltamethrin-1R induced a transient increase of [Ca2+] i mobilization in the thymocyte suspension after 10 min of in vitro treatment, and substantially reduced the rate of -calmodulin (Ca/CaM)-dependent protein dephosphorylation in in vivo treated animals (25 mg deltamethrin/kg for 24 hr). |
112(1,2,2,2) | Details |
| 20143453 | Harrill JA, Knapp GW, Crofton KM: Splice variant specific increase in Ca (2+)/calmodulin- dependent protein kinase 1-gamma mRNA expression in response to acute pyrethroid exposure. J Biochem Mol Toxicol. 2010 Feb 8. Previous work demonstrated increases in the expression of Ca (2+)/calmodulin-dependent protein kinase 1-gamma (Camk1g) mRNA following acute deltamethrin and permethrin exposure. |
32(0,1,1,2) | Details |
| 10575025 | Liu Q, Berg DK: Actin filaments and the opposing actions of CaM kinase II and calcineurin in regulating alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. J Neurosci. 1999 Dec 1;19(23):10280-8. Blockade of calmodulin by calmidazolium or blockade of CaM kinase II with either KN93 or autocamtide-2-related inhibitory peptide each prevents the rundown; blockade of the phosphatase calcineurin with either cyclosporin A or deltamethrin increases the rundown. |
31(0,1,1,1) | Details |
| 9714322 | Fakata KL, Swanson SA, Vorce RL, Stemmer PM: Pyrethroid insecticides as phosphatase inhibitors. . Biochem Pharmacol. 1998 Jun 15;55(12):2017-22. The type II pyrethroid insecticides cis-cypermethrin (c-Cyp), trans-cypermethrin, deltamethrin (Delt), and fenvalerate A alpha (Fen), as well as the type I pyrethroid insecticides cis- and trans-permethrin and S-bioallethrin, were unable to inhibit the phosphatase activity of purified calcineurin under conditions of maximal activation by Ca2+ and calmodulin. |
31(0,1,1,1) | Details |
| 9755112 | Verin AD, Cooke C, Herenyiova M, Patterson CE, Garcia JG: Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses. Am J Physiol. 1998 Oct;275(4 Pt 1):L788-99. Western immunoblotting revealed PPase 2B to be present in cytoskeletal EC fractions, with specific PPase 2B inhibitors such as cyclosporin (200 nM) and deltamethrin (100 nM to 1 microM) attenuating thrombin-induced cytoskeletal protein dephosphorylation, including EC MLC dephosphorylation. |
2(0,0,0,2) | Details |
| 8948591 | Carrera A, Moos J, Ning XP, Gerton GL, Tesarik J, Kopf GS, Moss SB: Regulation of protein phosphorylation in human sperm by a /calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for phosphorylation. Dev Biol. 1996 Nov 25;180(1):284-96. In this regard, the calcineurin inhibitor deltamethrin inhibited the Ca2+ ionophore-induced dephosphorylation. |
2(0,0,0,2) | Details |
| 1315545 | Enan E, Matsumura F: Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84. The inhibitory action of synthetic pyrethroids and some chlorinated hydrocarbon insecticides on the neural -calmodulin-dependent protein phosphatase, calcineurin, was studied using one radiotracer and two colorimetric methods. It was found that all insecticidal Type II pyrethroids (cypermethrin, deltamethrin and fenvalerate) are potent inhibitors of isolated calcineurin from bovine brain. |
1(0,0,0,1) | Details |
| 12242407 | Allen GJ, Sanders D: Calcineurin, a Type 2B Protein Phosphatase, Modulates the Ca2+-Permeable Slow Vacuolar Ion Channel of Stomatal Guard Cells. Plant Cell. 1995 Sep;7(9):1473-1483. The inhibitory effect of calcineurin could be blocked by the pyrethroid deltamethrin, indicating inhibition of SV channels by calcineurin via dephosphorylation. SV currents were potently modulated by the Ca2+-dependent, calmodulin-stimulated protein phosphatase 2B (calcineurin). |
1(0,0,0,1) | Details |
| 12785591 | Cassano G, Bellantuono V, Ardizzone C, Lippe C: Pyrethroid stimulation of ion transport across frog skin. . Environ Toxicol Chem. 2003 Jun;22(6):1330-4. The short-circuit current value (estimate of ion transport) was increased by each of the eight pyrethroids tested, with the following order of potency: lambda-cyhalothrin > deltamethrin > alpha-cypermethrin = beta-cyfluthrin > bioallethrin > permethrin > bioresmethrin > phenothrin. Finally, the stimulation by pyrethroids was inhibited by indomethacin and W7 (inhibitors of cyclooxygenases and the Ca2+/calmodulin system, respectively). |
1(0,0,0,1) | Details |
| 9572286 | Matsuda T, Takuma K, Asano S, Kishida Y, Nakamura H, Mori K, Maeda S, Baba A: Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. J Neurochem. 1998 May;70(5):2004-11. The Ca2+/calmodulin-dependent phosphatase calcineurin may have physiological and pathological roles in neurons, but little is known about the roles of the enzyme in glial cells. Deltamethrin (20 nM), another calcineurin inhibitor, had a similar protective effect, whereas okadaic acid did not. |
1(0,0,0,1) | Details |
| 9379408 | Traynelis SF, Wahl P: Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. J Physiol. 1997 Sep 15;503 ( Pt 3):513-31. Inclusion of purified calcineurin plus its coactivators 200 nM Ca2+ and calmodulin in the patch pipette decreases Po,peak to 0.48 +/- 0.10. The calcineurin-stimulated decrease of Po,peak in cells co-transfected with C alpha-PKA is blocked by 800 nM deltamethrin, a calcineurin inhibitor. |
1(0,0,0,1) | Details |
| 15746091 | Wu ZZ, Chen SR, Pan HL: Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated channels through -dependent calcineurin in sensory neurons. J Biol Chem. 2005 May 6;280(18):18142-51. Epub 2005 Mar 3. Furthermore, intracellular dialysis of deltamethrin or cyclosporin A, the specific calcineurin (protein phosphatase 2B) inhibitors, but not okadaic acid (a selective protein phosphatase 1/protein phosphatase 2A inhibitor), abolished the effect of on I (Ca). |
0(0,0,0,0) | Details |