| Name | calcineurin inhibitors |
|---|---|
| Synonyms | CABIN 1; CAIN; CABIN1; Calcineurin binding protein 1; Calcineurin binding protein cabin 1; Calcineurin inhibitor; Calcineurin binding protein 1s; Calcineurin binding protein cabin 1s… |
| Name | deltamethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9037753 | Robello M, Amico C, Cupello A: A dual mechanism for impairment of GABAA receptor activity by NMDA receptor activation in rat cerebellum granule cells. Eur Biophys J. 1997;25(3):181-7. The effect was reduced by including -5'-O-3-thiophosphate (ATP-gamma-S) in the internal solution and there was a reduction in the effect caused by deltamethrin, a calcineurin inhibitor. |
81(1,1,1,1) | Details |
| 18611438 | Ranta F, Dufer M, Stork B, Wesselborg S, Drews G, Haring HU, Lang F, Ullrich S: Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis. Cell Signal. 2008 Oct;20(10):1780-6. Epub 2008 Jun 18. Previously, we described that apoptotic cell death induced by the synthetic glucocorticoid dexamethasone (dex) is inhibited by calcineurin inhibitors, FK506 and deltamethrin, in insulin-secreting cells. |
31(0,1,1,1) | Details |
| 7531976 | Richter A, Davies DE, Alexander P: Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin. Biochem Pharmacol. 1995 Jan 31;49(3):367-73. The role of calcineurin in CyA- or FK506-induced growth inhibition was investigated using the synthetic pyrethroid insecticides: cypermethrin, deltamethrin and fenvalerate, which are known calcineurin inhibitors. |
31(0,1,1,1) | Details |
| 9379408 | Traynelis SF, Wahl P: Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. J Physiol. 1997 Sep 15;503 ( Pt 3):513-31. The calcineurin-stimulated decrease of Po,peak in cells co-transfected with C alpha-PKA is blocked by 800 nM deltamethrin, a calcineurin inhibitor. |
31(0,1,1,1) | Details |
| 8948591 | Carrera A, Moos J, Ning XP, Gerton GL, Tesarik J, Kopf GS, Moss SB: Regulation of protein phosphorylation in human sperm by a /calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for phosphorylation. Dev Biol. 1996 Nov 25;180(1):284-96. In this regard, the calcineurin inhibitor deltamethrin inhibited the Ca2+ ionophore-induced dephosphorylation. |
31(0,1,1,1) | Details |
| 16317049 | MacDonald PE, Eliasson L, Rorsman P: increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. J Cell Sci. 2005 Dec 15;118(Pt 24):5911-20. Epub 2005 Nov 29. Similar results were obtained upon direct application of 100 nM and 0.5 mM Ca2+ to the intracellular surface of inside-out excised membrane patches, and in these experiments the increase in vesicle capacitance was prevented by the calcineurin inhibitor deltamethrin. |
6(0,0,1,1) | Details |
| 16644695 | Ranta F, Avram D, Berchtold S, Dufer M, Drews G, Lang F, Ullrich S: Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4. Diabetes. 2006 May;55(5):1380-90. FK506 (0.1 micromol/l) and another calcineurin inhibitor, deltamethrin (1 micromol/l), attenuated dexamethasone-induced cell death. |
6(0,0,1,1) | Details |
| 10794729 | Bandyopadhyay A, Shin DW, Kim DH: Regulation of ATP-induced release in COS-7 cells by calcineurin. . Biochem J. 2000 May 15;348 Pt 1:173-81. Treatment of the cells with calcineurin inhibitors such as cyclosporin A (CsA), deltamethrin and FK506 resulted in an enhancement of ATP-induced intracellular Ca (2+) release. |
6(0,0,1,1) | Details |
| 9572286 | Matsuda T, Takuma K, Asano S, Kishida Y, Nakamura H, Mori K, Maeda S, Baba A: Involvement of calcineurin in Ca2+ paradox-like injury of cultured rat astrocytes. J Neurochem. 1998 May;70(5):2004-11. Deltamethrin (20 nM), another calcineurin inhibitor, had a similar protective effect, whereas okadaic acid did not. |
6(0,0,1,1) | Details |
| 16678970 | Wu ZZ, Chen SR, Pan HL: Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience. 2006 Aug 11;141(1):407-19. Epub 2006 May 6. Furthermore, calcineurin (protein phosphatase 2B) inhibitors (deltamethrin and FK-506) eliminated the effect of olvanil on voltage-activated Ca (2+) channel current. Notably, 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid, calmodulin antagonists, and calcineurin inhibitors each alone significantly increased the amplitude of voltage-activated Ca (2+) channel current. |
1(0,0,0,1) | Details |
| 11062058 | Bandyopadhyay A, Shin DW, Ahn JO, Kim DH: Calcineurin regulates ryanodine receptor/Ca (2+)-release channels in rat heart. Biochem J. 2000 Nov 15;352 Pt 1:61-70. Effects of calcineurin inhibitors were tested on neonatal-rat-heart cardiomyocytes. Treatment of neonatal cardiomyocytes with 20 microM deltamethrin, 10 microM cyclosporin A (CsA), or 10 mciroM FK506 led to Ca (2+) oscillations in originally quiescent cardiomyocytes. |
1(0,0,0,1) | Details |
| 10575025 | Liu Q, Berg DK: Actin filaments and the opposing actions of CaM kinase II and calcineurin in regulating alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. J Neurosci. 1999 Dec 1;19(23):10280-8. A membrane-permeable calcineurin inhibitor, however, still decreases the nicotinic response in a -dependent manner, confirming that -dependent phosphoregulation of alpha7-containing receptors occurs in the intact cell. Blockade of calmodulin by calmidazolium or blockade of CaM kinase II with either KN93 or autocamtide-2-related inhibitory peptide each prevents the rundown; blockade of the phosphatase calcineurin with either cyclosporin A or deltamethrin increases the rundown. |
1(0,0,0,1) | Details |
| 17551263 | Martin C, Jacobi JS, Nava G, Jeziorski MC, Clapp C, Martinez de la Escalera G: inhibition of cyclic AMP production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl cyclase 9. Neuroendocrinology. 2007;85(4):257-66. Epub 2007 Jun 4. Finally, increased phosphatase activity in a -dependent manner, an effect blocked by calcineurin inhibitors. Furthermore, blocking calcineurin with deltamethrin, FK-506 or cyclosporin A blocked the inhibitory effect of on [cAMP] i, supporting the involvement of AC9 in this effect. |
1(0,0,0,1) | Details |
| 15337272 | Choi JS, Soderlund DM: Cyclosporin A and deltamethrin block the downregulation of Nav1.8 channels expressed in Xenopus oocytes. Neurosci Lett. 2004 Sep 9;367(3):389-93. The use of a calcineurin inhibitor such as cyclosporin A provides an effective means of stabilizing the expression of Nav1.8 channels in oocytes for functional and pharmacological studies. |
1(0,0,0,1) | Details |
| 10844399 | Kampermann J, Herbst M, Ullrich S: Effects of and on insulin secretion in INS-1 cells under voltage control. Cell Physiol Biochem. 2000;10(1-2):81-90. After incubation of the cells with deltamethrin, a calcineurin inhibitor, the stimulation of secretion was attenuated, but the -induced inhibition was not affected. |
0(0,0,0,0) | Details |
| 11562451 | Dufer M, Krippeit-Drews P, Lembert N, Idahl LA, Drews G: Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells. Mol Pharmacol. 2001 Oct;60(4):873-9. This effect is not due to an inhibition of calcineurin, which mediates the immunosuppressive effect of CsA, because other calcineurin inhibitors, deltamethrin and tacrolimus, did not affect the oscillations in [Ca (2+)](c) of the B-cells. |
0(0,0,0,0) | Details |
| 10807662 | Wirkner K, Assmann H, Koles L, Gerevich Z, Franke H, Norenberg W, Boehm R, Illes P: Inhibition by A (2A) receptors of but not AMPA currents in rat neostriatal neurons. Br J Pharmacol. 2000 May;130(2):259-69. The calcineurin inhibitor deltamethrin did not interfere with CGS 21680. |
0(0,0,0,0) | Details |
| 8985861 | Hardwick JC, Parsons RL: Activation of the protein phosphatase calcineurin during carbachol exposure decreases the extent of recovery from end-plate desensitization. J Neurophysiol. 1996 Dec;76(6):3609-16. This staurosporine-induced decrease in sensitivity could be prevented by pretreatment with the protein phosphatase 2B (calcineurin) inhibitor deltamethrin (0.5 microM), whereas okadaic acid (5 microM) and calyculin A (0.5 microM), inhibitors of protein phosphatases 1 and 2A, had no effect. 3. |
0(0,0,0,0) | Details |