| Name | CIP1 |
|---|---|
| Synonyms | CAP20; CDKN1A; Cip1; PIC 1; PIC1; P21; CDK interacting protein 1; CDK interaction protein 1… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9806590 | Azzam EI, de Toledo SM, Gooding T, Little JB: Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res. 1998 Nov;150(5):497-504. The extent of modulation of TP53 and CDKN1A is significantly reduced in the presence of the gap junction inhibitor lindane and in irradiated low-density cell populations. |
83(1,1,1,3) | Details |
| 14688026 | Kalantzi OI, Hewitt R, Ford KJ, Cooper L, Alcock RE, Thomas GO, Morris JA, McMillan TJ, Jones KC, Martin FL: Low dose induction of micronuclei by lindane. . Carcinogenesis. 2004 Apr;25(4):613-22. Epub 2003 Dec 19. Despite a comparable high dose lindane induction of cell cycle arrest, marked increases in expression of P21WAF1/CIP1 were observed only in MCF-7 cells, although in PC-3 cells a significant increase (P < 0.0005) in the percentage of cells staining positive for p21Waf1/Cip1 was seen. |
6(0,0,1,1) | Details |
| 18174961 | Hewitt R, Forero A, Luncsford PJ, Martin FL: Enhanced micronucleus formation and modulation of BCL-2:BAX in MCF-7 cells after exposure to binary mixtures. Environ Health Perspect. 2007 Dec;115 Suppl 1:129-36. METHODS: In the presence or absence of lindane, chromosomal aberrations were detected in MCF-7 cells after 24-hr treatment with benzo [a] pyrene (B [a] P) or 2-amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) using the cytokinesis-block micronucleus assay. We investigated intracellular responses using quantitative gene expression analyses of cyclin-dependent kinase inhibitor 1A [CDKN1A (P21 (WAF1/CIP1))], B-cell leukemia/lymphoma 2 (BCL-2), BCL-2-associated X (BAX), and isoforms of cytochrome P450 (CYP), CYP1A1, CYP1A2, and CYP1B1. |
3(0,0,0,3) | Details |