| Name | aconitase |
|---|---|
| Synonyms | ACO 2; Aconitase; Citrate hydro lyase; ACO2; ACO2 protein; ACONM; Aconitase 2; Citrate hydrolyase aconitase… |
| Name | sodium fluoroacetate |
|---|---|
| CAS | sodium 2-fluoroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19741123 | Okada-Ogawa A, Suzuki I, Sessle BJ, Chiang CY, Salter MW, Dostrovsky JO, Tsuboi Y, Kondo M, Kitagawa J, Kobayashi A, Noma N, Imamura Y, Iwata K: Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms. J Neurosci. 2009 Sep 9;29(36):11161-71. The effects of intrathecal administration of the astroglial aconitase inhibitor sodium fluoroacetate (FA) were tested on Vc astroglial hyperactivity [as revealed by glial fibrillary acid protein (GFAP) labeling], nocifensive behavior, Vc extracellular signal-regulated kinase phosphorylation (pERK), and Vc neuronal activity in inferior alveolar nerve-transected (IANX) rats. |
31(0,1,1,1) | Details |
| 1242379 | Novak L, Juraskova V: Inhibition of DNA synthesis in mouse lymphosarcoma LS/BL cells by fluorocitrate. Folia Biol. 1975;21(4):244-9. Fluorocitrate is a specific inhibitor of aconitase activity (EC 4.2.1.3). A similar inhibitory effect upon DNA synthesis was also found in cells cultured in the abdominal cavity of host mice injected intraperitoneally with 5 mg./kg. of sodium fluoroacetate. |
1(0,0,0,1) | Details |
| 16696292 | Collicchio-Zuanaze RC, Sakate M, Schwartz DS, Trezza E, Crocci AJ: and for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation. Hum Exp Toxicol. 2006 Apr;25(4):175-82. The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to accumulation and resulting in interference in energy production by Krebs cycle blockade. |
1(0,0,0,1) | Details |
| 17288493 | Proudfoot AT, Bradberry SM, Vale JA: Sodium fluoroacetate poisoning. Toxicol Rev. 2006;25(4):213-9. Fluoroacetate combines with to form fluoroacetyl which can substitute for in the tricarboxylic acid cycle and reacts with citrate synthase to produce fluorocitrate, a metabolite of which then binds very tightly to aconitase, thereby halting the cycle. |
1(0,0,0,1) | Details |